The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum

Luciano-Rosario, Dianiris; Barda, Omer; Tannous, Joanna; Frawley, Dean; Bayram, Özgür; Prusky, Dov; Sionov, Edward; Keller, Nancy P.

doi:10.1016/j.fgb.2023.103837

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…4B ). These results corroborate the role of KERS complex as global regulator of mycotoxins, consistent with the findings for the A. nidulans and Penicillium expansum KERS complexes ( Karahoda et al, 2022 ; Luciano-Rosario et al, 2023 ).…”

Section: Kdmb and Rpda Are Global Regulators Of Secondary Metabolite ...supporting

confidence: 90%

“…Ortholog analysis strongly suggest that KERS members are highly conserved across various fungi and human. In addition to KERS complex in A. nidulans , this and an associated paper ( Luciano-Rosario et al, 2023 ) together suggest that KERS complex may be functionally and biochemically conserved in other pathogenic fungi and may be conserved in higher eukaryotes and human cells.…”

Section: Discussionmentioning

confidence: 72%

“…It is interesting to note the presence of a partial complex (KRS) composed of the KdmB, RpdA and SntB subunits (i.e. lacking EcoA) in species of the Penicillium genus ( Luciano-Rosario et al, 2023 ). The functional significance of the difference in the complex composition is not clear, but it highlights the importance of having coordinated recruitment of KdmB, RpdA and SntB to chromatin.…”

Section: Discussionmentioning

confidence: 99%

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The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus

Karahoda,

Pfannenstiel,

Sarikaya-Bayram

et al. 2023

Fungal Genetics and Biology

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Section: Kdmb and Rpda Are Global Regulators Of Secondary Metabolite ...supporting

confidence: 90%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus

Karahoda,

Pfannenstiel,

Sarikaya-Bayram

et al. 2023

Fungal Genetics and Biology

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Transcriptional memory drives accelerated re-activation of several biosynthetic gene clusters in Aspergillus nidulans.

Zehetbauer,

Berger,

Kastner

et al. 2025

Microbiological Research

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Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in Penicillium expansum and Penicillium chrysogenum

Bartholomew,

Gottschalk,

Cooper

et al. 2024

JoF

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Penicillium expansum is a ubiquitous pathogenic fungus that causes blue mold decay of apple fruit postharvest, and another member of the genus, Penicillium chrysogenum, is a well-studied saprophyte valued for antibiotic and small molecule production. While these two fungi have been investigated individually, a recent discovery revealed that P. chrysogenum can block P. expansum-mediated decay of apple fruit. To shed light on this observation, we conducted a comparative genomic, transcriptomic, and metabolomic study of two P. chrysogenum (404 and 413) and two P. expansum (Pe21 and R19) isolates. Global transcriptional and metabolomic outputs were disparate between the species, nearly identical for P. chrysogenum isolates, and different between P. expansum isolates. Further, the two P. chrysogenum genomes revealed secondary metabolite gene clusters that varied widely from P. expansum. This included the absence of an intact patulin gene cluster in P. chrysogenum, which corroborates the metabolomic data regarding its inability to produce patulin. Additionally, a core subset of P. expansum virulence gene homologues were identified in P. chrysogenum and were similarly transcriptionally regulated in vitro. Molecules with varying biological activities, and phytohormone-like compounds were detected for the first time in P. expansum while antibiotics like penicillin G and other biologically active molecules were discovered in P. chrysogenum culture supernatants. Our findings provide a solid omics-based foundation of small molecule production in these two fungal species with implications in postharvest context and expand the current knowledge of the Penicillium-derived chemical repertoire for broader fundamental and practical applications.

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The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum

Cited by 3 publications

References 41 publications

The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus

The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus

Transcriptional memory drives accelerated re-activation of several biosynthetic gene clusters in Aspergillus nidulans.

Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in Penicillium expansum and Penicillium chrysogenum

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