The histopathology of an interstitial nephritis in the fowl produced experimentally with infectious bronchitis virus

Histopathology and immunohistochemistry of renal lesions due to avian infectious bronchitis virus in chicks uninoculated and previously inoculated with highly virulent infectious bursal disease virus

“…Renal lesions consisting of tubular degeneration and an inflammatory cell reaction in the interstitium and tubules have been described in IBV-infected chickens (Chong & Apostolov, 1982;Fulton et al, 1993;Pohl, 1974;Purcell et al, 1976;Siller & Cumming, 1974). It was suggested that the renal lesions might be initiated as nephrosis that progresses to nephrosis-nephritis and lastly to interstitial nephritis (Chen et al, 1996).…”

Confirmation of nephrotropism and nephropathogenicity of three low‐pathogenic chicken‐origin influenza viruses for chickens

“…Gross and histological kidney lesions have been reported for some field cases and in some experimental studies with the coronavirus, infectious bronchitis (IBV) and the picornavirus, avian infectious nephritis (Siller & Cumming, 1974;Maeda et ah, 1979). In fact, since in the original field case from which influenza virus 378/85 (H10N4) was isolated chickens had prominent visceral urate deposition and 'nephropathy', IBV was initially suspected as the cause (Alexander & Gough, 1986).…”

Pathogenesis of infectious bronchitis nephritis. 2. Studies of water and electrolyte balance in colostomised chickens

“…Urine pH was 6 and no glucose was detected in the urine. DISCUSSION The disease reproduced in this study was typical of infectious bronchitis nephritis as described in natural outbreaks and under experimental conditions (Cumming, 1963;Siller and Cumming, 1974). It was more severe than in our previous experiment (Condron and Marshall, 1985), however, a larger infective dose was administered intravenously and the surgery may have caused the birds to be under more stress.…”

“…This is an economically important disease in Australia and many factors such as cold stress, nutrition, age and sex of the chicken influence the severity of the disease (Cumming, 1965;Sinkovic and Gilchrist, 1967;Macdonald et al, 1980). Those strains of the virus which induce more severe kidney disease are also associated with higher mortality rates (Siller and Cumming, 1974;Chong and Apostolov, 1982).…”

“…Histological investigations of the development of kidney lesions throughout the course of experimental infections have shown interstitial inflammatory reactions and tubular degeneration (Siller and Cumming, 1974;Pohl, 1974;Purcell et al, 1976). In a morphometric analysis of the ultrastructural changes in the proximal tubular epithelium following infection with IBV, Condron and Marshall (1985) found a reduction in the functional components of the cells.…”