The history of biomaterials used for breast augmentation

Peters, Walter

doi:10.1533/9780857096418.1

Cited by 5 publications

(6 citation statements)

References 62 publications

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“…Average Molecular Weight (M n ). The structural compositions of HP-PCL, nBu-PCL-HP, and ISAL-PCL-HP were confirmed by FT-IR, 1 H NMR, and 13 C NMR spectroscopies. The number average molecular weight (M n ) of these synthesized conjugates was calculated by substituting the appropriate values obtained in eqs 1 and 2.…”

Section: Resultsmentioning

confidence: 88%

“…Polymers are booming ubiquitously in every branch of science, ranging from automobiles to health care. Ironically, polymers are continuously giving progressive results in medical and industrial fields. , Polymer therapeutics involve the use of conjugates and polymeric nanocarriers for drug delivery and other biomedical applications. This approach is one of the most fruitful approaches over conventional drug delivery.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates

Rani

Gupta

2021

ACS Omega

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The design, synthesis, and physicochemical characterization of conjugates are arduous and tedious processes. Several synthetic pathways for polymeric conjugation have been reported; however, conjugation through monomers with suitable reaction conditions can be a simple and robust approach. In the present study, three different conjugates of hydrophilic N-2-hydroxypropyl methacrylamide (HPMA) and hydrophobic polycaprolactone (PCL) were synthesized. The followed synthetic pathway not only was simple and robust but also reduced the overall synthetic steps as well as harsh reaction conditions significantly. In a nutshell, three conjugates, i.e., N-2-hydroxypropyl methacrylamide and polycaprolactone (HP-PCL), n-butanol-polycaprolactone-N-2-hydroxypropyl methacrylamide (nBu-PCL-HP), and isoamyl alcohol-polycaprolactone-N-2-hydroxypropyl methacrylamide (ISAL-PCL-HP), were synthesized through this simple synthetic strategy following the monomer conjugation approach along with exhaustive spectroscopic and rheological characterization. The conjugates HP-PCL, nBu-PCL-HP, and ISAL-PCL-HP were characterized by Fourier transform infrared (FT-IR) and NMR (13C and 1H) spectroscopies. The size and ζ potential of conjugates were determined through the dynamic light scattering (DLS) method. The nBu-PCL-HP conjugate displayed a hexagonal-like shape, as evidenced by scanning electron microscopy (SEM) with an obtained size of 237.9 ± 0.21 nm. X-ray diffraction (XRD) analysis proved the crystalline nature of nBu-PCL-HP conjugates. The results of smartly synthesized conjugates intrigued us to study their flow properties in detail. Rheological evaluation resulted in their non-Newtonian type of flow with the best-fit behavior for all of the conjugates followed as per the Herschel–Bulkley and power-law models applied herein. Conclusively, the synthesized HPMA and PCL conjugates may have applications in the preparation of blends, fibers, etc. in the future. The study portrayed that the explored synthetic scheme using monomers and initiators could be a suitable approach for the synthesis of HPMA and PCL conjugates.

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Section: Resultsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates

Rani

Gupta

2021

ACS Omega

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“…From 1951 to 1963, a number of different sponges were used for breast augmentation, including polyvinyl alcohol sponge and polyethylene sponge. Still, they were associated with a very high incidence of capsular contracture [6]. In 1963, Cronin and Gerow introduced the first silicone gel breast implant [7].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in the Presence of Failed Saline Breast Implants

Monib¹,

Thomson²

2021

Cureus

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Breast augmentation has been gaining popularity over the last two decades to correct congenital breast asymmetry or increase breast size and projection. Augmentation options started with saline implants, then silicone implants, and, recently, autologous fat transfer.Unfortunately, breast implants are not without complications, some of which are common, like capsular contracture, implant failure and infection. Others are quite rare, such as Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). Most of these complications will eventually require explantation in most cases, as the patients' and implants' age and risk of complications increase.We present a 79-year-old patient who presented to our breast unit with a left breast lump with 50-year-old saline implants. A triple assessment revealed incidental right breast cancer treated with radiofrequency identification (RFID) tag-guided wide local excision, sentinel lymph node biopsy and bilateral explantation.

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“…The tube was wrapped around a slated wooden drum and revolved in a tank filled with dialyzing solution [1]. In the 50s and 60s poly(vinyl alcohol) sponges (Ivalon) were used as breast implants [2]. Silicones have been used in several applications (tubings, shunts, urethra, joints) since the 1950s [3].…”

Section: Introduction and Historical Backgroundmentioning

confidence: 99%

Design of smart HPMA copolymer-based nanomedicines

Yang

Kopeček

2016

Journal of Controlled Release

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The state-of-the art in water-soluble macromolecular therapeutics has been reviewed. First the design principles for polymer-drug conjugates are discussed followed by two recent developments in the field: a) The design, synthesis and properties of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates. The enhanced intravascular half-life of such conjugates creates a concentration gradient (blood vs. tumor) for an extended time interval resulting in increased solid tumor accumulation by enhanced permeability and retention (EPR) effect with concomitant increase in efficacy. b) Drug-free macromolecular therapeutics is a new paradigm in macromolecular therapeutics. Apoptosis in malignant cell is induced by crosslinking of cell surface non-internalizing receptors. Crosslinking of receptors is mediated by the biorecognition of two nanoconjugates containing high-fidelity complementary motifs (peptides or oligonucleotides). Results for the treatment of B cell lymphomas in animal models and patient cells demonstrate the high translational potential of this aproach.

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The history of biomaterials used for breast augmentation

Cited by 5 publications

References 62 publications

Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates

Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates

Breast Cancer in the Presence of Failed Saline Breast Implants

Design of smart HPMA copolymer-based nanomedicines

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