The History of Injectable Facial Fillers

Kontis, Theda C.; Rivkin, Alexander

doi:10.1055/s-0029-1220645

Cited by 100 publications

(81 citation statements)

References 9 publications

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“…In 1981, bovine collagen (Zyplast®) was the first facial filler approved for cosmetic use in the United States. Besides bovine collagen, human-derived bioengineered (CosmoDerm®/CosmoPlast®) and porcine collagen (Evolence®) are used as dermal fillers [12][13][14]. All injectable collagen products are composed of lidocaine (approximately 0.3 %) and a phosphate-buffered saline solution of 35 mg/mL (up to 65 mg/mL) of collagen [15].…”

Section: Temporary Fillersmentioning

confidence: 99%

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Luebberding

Alexiades-Armenakas

2013

Curr Derm Rep

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Injectable cosmetic wrinkle fillers are soft-tissue fillers approved as medical devices by the U.S. Food and Drug Administration (FDA). These devices are injected into the skin for correcting soft-tissue contour defects, such as moderate and severe wrinkles and folds, and for restoring the signs of facial fat loss in people with human immunodeficiency virus. Although the aesthetic treatment with injectable dermal fillers is considered to be safe, adverse events are involved with this minimally-invasive treatment. The FDA received 930 post-marked reports of adverse event from 2003 through 2008, of which 823 were deemed severe and 638 required medical treatment and follow-up.

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Section: Temporary Fillersmentioning

confidence: 99%

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Luebberding

Alexiades-Armenakas

2013

Curr Derm Rep

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“…Crosslinked HA fillers have been used for longer than 15 years6 and are considered to be generally well tolerated. They have structural properties similar to those of native tissue, excellent biocompatibility, and good tissue integration 7,8. They have a tunable duration of action spanning the entire range of the temporary filler category (6–24 months), and because of their relatively stable molecular composition, they can be stored without refrigeration for up to 2 years.…”

mentioning

confidence: 99%

A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers

Boulle¹,

Glogau²,

Kono³

et al. 2013

Dermatologic Surgery

222

175

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BackgroundCosmetic procedures are growing ever more common, and the use of soft tissue fillers is increasing. Practicing physicians need to be aware of the biological behavior of these products in tissue to enable them to respond to any safety concerns that their patients raise.ObjectivesTo provide an overview of the metabolism of 1,4-butanediol diglycidyl ether (BDDE)-crosslinked hyaluronic acid (HA) dermal fillers and to examine the safety of the resulting byproducts.MethodsA review of available evidence was conducted.ResultsAfter reaction with HA, the epoxide groups of BDDE are neutralized, and only trace amounts of unreacted BDDE remain in the product (<2 parts per million). When crosslinked HA, uncrosslinked HA, and unreacted BDDE degrade, they break down into harmless byproducts or into byproducts that are identical to substances already found in the skin.ConclusionClinical and biocompatibility data from longer than 15 years support the favorable clinical safety profile of BDDE-crosslinked HA and its degradation products. Given the strength of the empirical evidence, physicians should be confident in offering these products to their patients.

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“…1 Perhaps the first substance used as a facial filler agent was paraffin, which was abandoned once significant complications such as migration, embolization, and granuloma formation were noted. 1 In recent years, many products have been developed and approved for use as dermal and subdermal injectable fillers for facial rejuvenation. These treatments have been increasing in popularity because they yield desirable esthetic outcomes without invasive surgical procedures.…”

mentioning

confidence: 99%