The History of Lymphoma Classifications with Special Consideration of Cutaneous Lymphomas

Abstract

For the modern evidence based medicine classification systems are necessary to guarantee a unifying approach for therapy and for prognosis of diseases. The comparability of clinical studies depends of the usage of adequate classification systems. But because all classifications are artificial, they only mirror the technical possibilities of its area.This review discusses the history of lymphoma classifications systems with a special focus on the topic of primary cutaneous lymphomas and the retikuloendothelial system. Furthermore special problems in terminology are discussed.clinical behavior and prognosis than histologically, cytomorphologically and immunohistochemically identical secondary cutaneous and nodal lymphomas [13]. However, for years the B-cell lymphomas in particular were divided into a classification system for nodal lymphomas which was partly not reproducible, resulting in serious consequences for treatment, which failed to meet the prognosis [13,14].

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Burkitt's lymphoma: A case report and review

“…As a result, the classification of lymphomas has undergone a significant reassessment over the past 40 years from Rappaport's classification in 1973 to World Health Organization (WHO) classification in 2008, wherein the classifications were renewed and updated. [ 7 ]…”

“…The WHO now recognizes a group of high-grade B-cell lymphomas that were not readily classified as either Burkitt's lymphoma (BL) or diffuse large B-cell lymphoma (DLBCL), into a provisional category termed as B-cell Lymphoma unclassifiable, with features intermediate between DLBCL and BL (WHO 2008). [ 7 ] These lesions usually occur in adults and are rare in young individuals more so as intraoral primary lesions. Herewith, we present such an unusual primary isolated, intraoral lesion without systemic involvement in a very young patient.…”