The History of Neuroimmune Biology

Berczi, István; Szentivanyi, Andor

doi:10.1016/s1567-7443(07)10001-6

Cited by 4 publications

(2 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the normal brain, the ECM contains high levels of glycosaminoglycan, hyaluronan, and proteoglycans, and low levels of fibrous proteins such as collagens, fibronectin, and laminin (Ruoslahti, ; Zimmermann & Dours‐Zimmermann, ). Fibrous proteins are the major components of basement membranes of the brain’s vasculature system (Berczi & Szentiványi, ). The aggressive glioblastoma alters the ECM microenvironment by generating collagens (I and IV), fibronectin, and laminin (Mahesparan et al, ).…”

Section: Introductionmentioning

confidence: 99%

The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices

Kaphle

Yao

2018

Journal Cellular Physiology

View full text Add to dashboard Cite

The invasion of glioblastoma is a complex process based on the interactions of tumor cells and the extracellular matrix. Tumors that are engineered using biomaterials are more physiologically relevant than a two-dimensional (2D) cell culture system. Matrix metalloproteinases and the plasminogen activator generated by tumor cells regulate a tumor's invasive behavior. In this study, microtumors were fabricated by encapsulating U87 glioma cells in Type I collagen and then glioma cell migration in the collagen hydrogels was investigated. Crosslinking of collagen with 8S-StarPEG increased the hydrogel viscosity and reduced the tumor cell migration speed in the hydrogels. The higher migration speed corresponded to the increased gene expression of MMP-2, MMP-9, urokinase plasminogen activator (uPA), and tissue plasminogen activator (tPA) in glioma cells grown in non-crosslinked collagen hydrogels. Inhibitors of these molecules hindered U87 and A172 cell migration in collagen hydrogels. Aprotinin and tranexamic acid did not inhibit U87 and A172 migration on the culture dish. This study demonstrated the differential effect of pharmacologic molecules on tumor cell motility in either a 2D or three-dimensional culture environment.

show abstract

Section: Introductionmentioning

confidence: 99%

The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices

Kaphle

Yao

2018

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…O diagrama também destaca que os barorreceptores e quimiorreceptores poderiam ser ativados por citocinas pró-inflamatórias liberadas pelas células imunes. Assim, o médico húngaro, Andor Szentivanyi, identificou a ausência dessas informações na literatura, e na década de 50 passou a se dedicar ao estudo de áreas cerebrais, como a região anterior do hipotálamo, que poderiam estar relacionadas ao efeito anafilático e a produção de anticorpos (FILIPP; SZENTIVANYI, 1958; FILIPP; SZENTIVANYI; MESS, 1952;SZENTIVANYI;FILIPP, 1958;SZENTIVANYI;SZEKELY, 1956).…”

unclassified