The history of the idea of allergy

Igea, J

doi:10.1111/all.12174

Cited by 65 publications

(29 citation statements)

References 29 publications

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“…6 A review and update of hypersensitivity (allergy) concepts was presented by Kay 4 and reviewed by Igea. 7 The allergy conditions seen in pediatric allergy clinics were defined by a Nomenclature Committee for dissemination by the European Academy of Allergology and Clinical Immunology, World Allergy Organization, and American Academy of Allergy, Asthma, and Clinical Immunology. 8 The original Gell and Coombs 2 hypersensitivity reactions, with a modification by Rajan 6 are outlined in Table 1.…”

Section: Hypersensitivity Terminology: Historical and Currentmentioning

confidence: 99%

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Hopp

2020

Pediatric Allergy, Immunology, and Pulmonology

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The explanation of hypersensitivity reactions has long relied on the classification of Gell and Coombs, originally proposed in the 1960s. However, their concepts were predated by other authors by at least 50 years. A 21st century pediatric allergy clinic provides multiple examples of these basic concepts on a daily basis. We review classic and less classic examples of the original criteria, highlight where current disease pathophysiology does not always fit the original model, and provide updated language for common and uncommon immunologically driven hypersensitivity diseases.

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Section: Hypersensitivity Terminology: Historical and Currentmentioning

confidence: 99%

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Hopp

2020

Pediatric Allergy, Immunology, and Pulmonology

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“…Von Pirquet observed that changes in reactivity occurred on subsequent exposures to an antigen. In some instances, re-exposure resulted in diminished reactivity whereas in others reactivity increased (Igea, 2013). A major advance in the understanding of food allergy occurred in 1921, when Prausnitz and Kustner determined that hypersensitivity to an antigen could be passively transferred with serum from one individual—namely, Kustner, who was allergic to fish—to another—namely, Prausnitz, who was not allergic to fish—by intradermal injection.…”

Section: Why Does Allergy Exist?mentioning

confidence: 99%

The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease

2016

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Allergic disease affects millions. Despite many advances in our understanding of the immune system in the past century, the physiologic underpinning for the existence of allergy remains largely mysterious. Food allergies, in particular, have increased dramatically in recent years, adding a new sense of urgency to unraveling this mystery. The concurrence of significant lifestyle changes in Western societies with increasing disease prevalence implies a causal link. Demographic variables that influence the composition and function of the commensal microbiota early in life seem to be most important. Identifying the evolutionary and physiologic foundations of allergic disease and defining what about our modern environment is responsible for its increased incidence will provide insights critical to the development of new approaches to prevention and treatment.

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“…This definition indicates a change in the sensitivity of the organism to substances with which the organism previously contacted. [1] At first, the allergic reactivity was connected to the development of inflammatory reaction in the point of allergen influence. Later, with the data discovery for histohematic barriers role, the new views on the allergy development mechanism shave formed.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Iryna¹

2018

AJP

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Introduction: The work represents the data about the worldwide spread age of allergic diseases both among adult and childish population. The given information is released according to the literary data analysis, including the WHO data. By studying these literary data, we prove the actuality of new antiallergic medicines creation, particularly, in pediatrics. Materials and Methods:The experimental part represents the study results of antihistamine activity, acute toxicity, and safety of new drug for the children's allergic disease medication. The research has been using pharmacological, physiological, and instrumental methods alongside the mathematical statistics method. Results and Discussion: As a result for investigations, we defined, that Loravit, a new antihistamine drug, prevents the conglomeration of homocytotropic antibodies, suppresses the mastocytes degranulation, which speaks of its manifested antiallergic activity. While investigating the drug's acute toxicity, the Loravit test sample in 5000 mg/kg dose was defined not to cause the animals death and influences the mass coefficients of internal organs, which proves the absence of meaningful test sample toxicity in the given dose, which characterizes it as non-toxic. Summary: By the investigation of Loravit suppositories pharmacological activity, its test samples were proven to obtain a manifested antiallergic activity. By the results of toxicological investigations, the new loratadine hydrochloride-based drug is considered to be mostly non-toxic (toxicity Class V, LD 50 >5000 mg/kg) according to the general toxicity classification. The results of investigations allow to consider the developed drug to be perspective for further production and market implementation.

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The history of the idea of allergy

Cited by 65 publications

References 29 publications

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease

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