The histotoxicity of cyanoacrylates

Vinters, Harry V.; Galil, Khadry; Lundie, Mark; Kaufmann, J. C. E.

doi:10.1007/bf00339559

Cited by 199 publications

(98 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, shorter chain derivatives such as ethyl cyanoacrylate have been found to be more histotoxic than longer chain derivatives 21,22 . This method is simpler and more time efficient due to the use of curved irrigation cannulae with olive tips.…”

mentioning

confidence: 99%

Isolation of Human Hepatocytes by a Two-step Collagenase Perfusion Procedure

Lee¹,

Schelcher²,

Demmel³

et al. 2013

JoVE

View full text Add to dashboard Cite

The liver, an organ with an exceptional regeneration capacity, carries out a wide range of functions, such as detoxification, metabolism and homeostasis. As such, hepatocytes are an important model for a large variety of research questions. In particular, the use of human hepatocytes is especially important in the fields of pharmacokinetics, toxicology, liver regeneration and translational research. Thus, this method presents a modified version of a two-step collagenase perfusion procedure to isolate hepatocytes as described by Seglen 1 . Previously, hepatocytes have been isolated by mechanical methods. However, enzymatic methods have been shown to be superior as hepatocytes retain their structural integrity and function after isolation. This method presented here adapts the method designed previously for rat livers to human liver pieces and results in a large yield of hepatocytes with a viability of 77±10%. The main difference in this procedure is the process of cannulization of the blood vessels. Further, the method described here can also be applied to livers from other species with comparable liver or blood vessel sizes. Video LinkThe video component of this article can be found at

show abstract

mentioning

confidence: 99%

Isolation of Human Hepatocytes by a Two-step Collagenase Perfusion Procedure

Lee¹,

Schelcher²,

Demmel³

et al. 2013

JoVE

View full text Add to dashboard Cite

show abstract

“…Bacterial genome experiments have demonstrated that NBCA and IBCA are mutagenic; however, they have not been proven to be carcinogenic [6]. NBCA is applied to skin wounds to achieve hemostasis.…”

Section: Cyanoacrylatesmentioning

confidence: 99%

Guidelines for the use of NBCA in vascular embolization devised by the Committee of Practice Guidelines of the Japanese Society of Interventional Radiology (CGJSIR), 2012 edition

et al. 2014

View full text Add to dashboard Cite

“…Possible complications of cyanoacrylate varicocele embolization are glue migration into the pulmonary circulation, a glued catheter and severe phlebitis of the gonadal vein or pampiniform plexus (26)(27)(28). We had no complications in our series because the glue embolization was performed by radiologists with considerable experience in the use of tissue adhesives.…”

Section: Discussionmentioning

confidence: 89%

Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate

Loffroy¹,

Mourey²,

Genson³

et al. 2016

Journal of Vascular and Interventional Radiology

View full text Add to dashboard Cite

Background: To evaluate pain, radiation and recurrence rates in patients undergoing varicocele embolization with three different embolic materials.Methods: Retrospective study of 182 consecutive patients who underwent transcatheter retrograde varicocele embolization from July 2011 to May 2015 with glue (Glubran ® 2) (group 1, n=63), mechanical agents (coils and/or plugs) (group 2, n=53) or a sclerosing agent (polidocanol) (group 3, n=66). Patients were asked by telephone interview to evaluate pain during embolization and at 1, 7 and 30 days using a quantitative pain scale ranging from 0 to 10. Duration of scopy, kinetic energy released per unit mass (kerma) and dose area product (DAP) were assessed as radiation parameters during embolization procedures.Recurrence rates after treatment were also evaluated. Statistical analyses were performed using parametric and non-parametric tests.Results: Patients in the three study groups were comparable for age, clinical indication and embolization side. No difference was noted for significant pain (pain score ≥3) during embolization and at 1, 7 and 30 days after treatment. Discomfort (pain score <3) was more frequent in group 1 than in groups 2 and 3 at 7 days after the procedure (P=0.049). No difference in discomfort was noted during embolization or at 1 and 30 days. Duration of scopy was shorter (P<0.0001) and kerma was lower (P=0.0087) in group 1 than in groups 2 and 3. DAP was lower in group 1 than in group 2 (P=0.04) but no difference was noted between groups 1 and 3, and groups 2 and 3. The recurrence rate at a mean follow-up of 24.4 months (range, 2-53 months)was significantly lower in group 1 than in the two other groups (P=0.032).Conclusions: The use of Glubran ® 2 acrylic glue for varicocele embolization is safe and leads to less radiation and lower recurrence rates than is the case for other embolic materials without any more significant pain.

show abstract

The histotoxicity of cyanoacrylates

Cited by 199 publications

References 105 publications

Isolation of Human Hepatocytes by a Two-step Collagenase Perfusion Procedure

Isolation of Human Hepatocytes by a Two-step Collagenase Perfusion Procedure

Guidelines for the use of NBCA in vascular embolization devised by the Committee of Practice Guidelines of the Japanese Society of Interventional Radiology (CGJSIR), 2012 edition

Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate

Contact Info

Product

Resources

About