The HLA allele marker for differentiating ASA hypersensitivity phenotypes

Lee, H.‐Y.; Lee, J.‐W.; Lee, K.‐W.; Park, M.‐H.; Park, H.‐S.

doi:10.1111/j.1398-9995.2009.02048.x

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…In addition, a SEA-specific IgE response may contribute to increased airway hyperresponsiveness, while a SEB-specific IgE response could contribute to increased peripheral eosinophil counts. Previous studies have reported that HLA allele DPB1*0301 is a strong marker for AERD because patients with this allele presented with an AERD phenotype, such as a decreased FEV 1 % and high comorbidity of CRS with nasal polyps [33,34,35]. In this study, no significant association between IgE sensitization to SEAs and the HLA-DBP*0301 allele was found.…”

Section: Discussioncontrasting

confidence: 49%

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Yoo¹,

Shin²,

Liu³

et al. 2013

Int Arch Allergy Immunol

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Background: Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated with eosinophilic inflammation and leukotriene production. However, the role of SAg-specific IgE in the pathogenesis of AERD is not well understood. We evaluated the clinical significance of serum IgE specific for three types of SAg, namely staphylococcal enterotoxins A and B (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1) in AERD. Methods: We enrolled 147 patients with AERD confirmed by a lysine-acetyl salicylic acid bronchoprovocative test and compared them with 147 patients with aspirin-tolerant asthma (ATA) and 141 healthy controls (NC). The levels of serum total IgE and SAg-specific IgE were measured using an ImmunoCAP system. Other clinical parameters were analyzed retrospectively. Results: The prevalences of SEA-, SEB- and TSST-1-specific IgE in the AERD and ATA groups were significantly higher than those in the NC group (p < 0.05, respectively). The total IgE level was significantly higher in patients with AERD with high levels of SEA-specific IgE than in those with lower levels (p < 0.05), with significant positive correlations between total and SAE-specific IgE levels (p < 0.05). The PC₂₀ methacholine level was significantly lower in patients with AERD with high levels of SEA-specific IgE, while a significantly higher eosinophil count was noted in patients with AERD with high levels of SEB-specific IgE (p < 0.05, respectively). Conclusions: Specific IgE responses to SAg may increase the serum total IgE level, airway hyperresponsiveness and eosinophil activation, leading to more severe clinical symptoms in AERD.

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Section: Discussioncontrasting

confidence: 49%

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Yoo¹,

Shin²,

Liu³

et al. 2013

Int Arch Allergy Immunol

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“…25 Interestingly, HLA-DPB1*0301 has been associated with AERD, 27 and it is also proposed as a genetic marker of aspirin hypersensitivity. 11 Interestingly, HLA-DPB1*0301 was strongly associated with the percentage of decline in FEV1 after aspirin challenge test. 27 HLA-DPB1*0301 polymorphisms are associated with tumor necrosis factor-α polymorphisms, which highlights genetic interaction of genes located on chromosome 6 in susceptibility to AIA.…”

Section: Discussionmentioning

confidence: 96%

“…HLA-DPB1*0301, member of MHC class II family, has been reported as a susceptibility allele to AIA in several populations. [9][10][11] Interestingly, HLA-DPB1*0301 may predict leukotrien inhibitor requirement in patients with AERD. 12 By contrast, limited data exist on the association of other HLA genes with AERD.…”

mentioning

confidence: 99%

HLA-DRB and HLA-DQ Genetic Variability in Patients with Aspirin-Exacerbated Respiratory Disease

Esmaeilzadeh

Nabavi

Amirzargar

et al. 2015

Am J Rhinol�Allergy

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“…The methacholine provocative concentration causing a 20% fall in FEV1% (PC 20 ) was also collected . The HLA‐DPB1*0301 allele was analyzed by a high‐resolution technique as previously described . The levels of serum total IgE and eosinophil cationic protein (ECP) were measured using the UniCAP system (Thermo Fisher Scientific, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

Lee

Kim

et al. 2016

Allergy

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The HLA allele marker for differentiating ASA hypersensitivity phenotypes

Cited by 11 publications

References 7 publications

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

HLA-DRB and HLA-DQ Genetic Variability in Patients with Aspirin-Exacerbated Respiratory Disease

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

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