The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population

Abstract

Background. Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C⁎12 and psoriasis in the Turkish population. The present study aims to determine this relationship. Methods. This case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C⁎06, HLA-C⁎12, and HLA-C⁎04 alleles were most commonly observed in psoriasis patients. HLA-C⁎06 and HLA-C⁎12 were significantly more frequent in the psoriasis group. HLA-C⁎06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C⁎12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C⁎12 allele. Conclusions. HLA-C⁎12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.

HLA-Cw1 and Psoriasis

“…A summary of characteristics of patients with psoriasis carrying HLA-Cw1 in comparison to HLA-Cw6 is provided in Table 2. HLA-Cw6 is the most well-recognized HLA serotype, affecting susceptibility, phenotype, disease Ethnicities Kuwait [15] All ethnicities (higher in Caucasians) Pakistan [16] Singapore Chinese [17] Southern Chinese [11] Thai [12] Turkish [14] Phenotypes…”

“…Additionally, the HLA-C*01 allele was significantly more frequent in Turkish patients with psoriasis than in control groups (8.1% vs 2.1%, p = 0.02), leading to an OR of 4.15 (95% confidence interval [CI] 1.15-15.01) [14]. In one study that recruited Kuwait children, the association of HLA-Cw1 with psoriasis was observed in 9 out of 50, resulting in an OR of 3.01 (95% CI 1.00-9.50) [15].…”

“…Recently, HLA-C*01:02 and HLA-A*02:07 were reported to confer a specific risk for psoriatic patients in Southern China [11]. HLA-C*01 has also been identified as a common HLA-C in some other ethnicities [11][12][13][14][15][16][17].…”

HLA Allele Prevalence in Disease-Modifying Antirheumatic Drugs-Responsive Enthesitis and/or Arthritis Not Fulfilling ASAS Criteria: Comparison with Psoriatic and Undifferentiated Spondyloarthritis

“…Interestingly, we found that both HLA-A28(68) and Cw12 were also associated with ASAS − but not with PsA or uSpA, suggesting that these alleles can confer susceptibility to ASAS − . While HLA-A28, with its splits 68 and 69, has been demonstrated to be significantly associated with B27 risk-related diseases, including AS [ 23 ], reactive arthritis [ 23 ], juvenile chronic polyarthropathy [ 23 ], and intermediate uveitis [ 24 ], only a minimal predisposition to cutaneous psoriasis has been reported for HLA-Cw12 [ 25 , 26 ].…”

Precision therapy for psoriasis patients

“…Описаны генетические маркеры, позволяющие прогнозировать характер течения заболевания или развития определенной клинической формы. Например, при обнаружении аллеля HLA-C*12 и полиморфного варианта Pro гена p53 (регулирует клеточный цикл) повышена вероятность тяжелого течения псориаза [19,20].…”