The HOG pathway and the regulation of osmoadaptive responses in yeast

Nadal, Eulàlia de; Posas, Francesc

doi:10.1093/femsyr/foac013

Cited by 48 publications

(40 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2018 ). In summary, these studies emphasize the surprisingly wide set of cellular functions, both direct and indirect, that show an Hog1-mediated phosphorylation response during hyperosmotic stress (de Nadal and Posas 2022 ).…”

Section: Different Signaling Routes Are Activated During Hyperosmotic...mentioning

confidence: 65%

Yeast osmoregulation – glycerol still in pole position

Blomberg

2022

FEMS Yeast Research

View full text Add to dashboard Cite

In response to osmotic dehydration cells sense, signal, alter gene expression and metabolically counterbalance osmotic differences. The main compatible solute/osmolyte that accumulates in yeast cells is glycerol, which is produced from the glycolytic intermediate dihydroxyacetone phosphate. This review covers recent advancements in understanding mechanisms involved in sensing, signaling, cell-cycle delays, transcriptional responses as well as post-translational modifications on key proteins in osmoregulation. The protein kinase Hog1 is a key-player in many of these events, however, there is also a growing body of evidence for important Hog1-independent mechanisms playing vital roles. Several missing links in our understanding of osmoregulation will be discussed and future avenues for research proposed. The review highlights that this rather simple experimental system—salt/sorbitol and yeast—has developed into an enormously potent model system unravelling important fundamental aspects in biology. ‘Striving for an integrative view’ (Stefan Hohmann, 2002)

show abstract

Section: Different Signaling Routes Are Activated During Hyperosmotic...mentioning

confidence: 65%

Yeast osmoregulation – glycerol still in pole position

Blomberg

2022

FEMS Yeast Research

View full text Add to dashboard Cite

show abstract

“…The high-osmolarity glycerol (HOG) pathway is necessary for tolerance to a variety of environmental stresses and immune responses in the host system [ 104 , 105 ]. HogA (also called SakA) is a key kinase in the HOG pathway in fungi [ 106 ].…”

Section: Distribution Of Key Developmental Regulators In As...mentioning

confidence: 99%

Regulation of Conidiogenesis in Aspergillus flavus

Cho

Son

Chen

et al. 2022

Cells

View full text Add to dashboard Cite

Aspergillus flavus is a representative fungal species in the Aspergillus section Flavi and has been used as a model system to gain insights into fungal development and toxin production. A. flavus has several adverse effects on humans, including the production of the most carcinogenic mycotoxin aflatoxins and causing aspergillosis in immune-compromised patients. In addition, A. flavus infection of crops results in economic losses due to yield loss and aflatoxin contamination. A. flavus is a saprophytic fungus that disperses in the ecosystem mainly by producing asexual spores (conidia), which also provide long-term survival in the harsh environmental conditions. Conidia are composed of the rodlet layer, cell wall, and melanin and are produced from an asexual specialized structure called the conidiophore. The production of conidiophores is tightly regulated by various regulators, including the central regulatory cascade composed of BrlA-AbaA-WetA, the fungi-specific velvet regulators, upstream regulators, and developmental repressors. In this review, we summarize the findings of a series of recent studies related to asexual development in A. flavus and provide insights for a better understanding of other fungal species in the section Flavi.

show abstract

“…This is achieved by the changes in gene expression and accumulation of compatible osmolytes combined, in some cases, with the activity of contractile vacuoles (Hoef‐Emden, 2014; Hosseiniyan Khatibi et al, 2019). Osmotolerance has been observed in bacteria (Kotecka et al, 2021; Mikušević et al, 2019; Paul et al, 2008), yeast (de Nadal & Posas, 2022; Harding et al, 2016; Klipp et al, 2005; Tanaka et al, 2014; Tatebayashi et al, 2020), plants (Golldack et al, 2014; Li et al, 2021a; Tang et al, 2021; Wang et al, 2022), and mammalian cells (Huang et al, 2011; Kang et al, 2021; Lanaspa et al, 2010; Lee et al, 2011; Sadowska et al, 2018; Snuggs et al, 2021). In particular, it has been extensively studied in medullary kidney cells (Berl, 2009), where osmolarity can vary from 600 to 1000 mOsm/kg depending on hydration and water balance of the body.…”

Section: Role In Osmoregulationmentioning

confidence: 99%

The old and the new about the contractile vacuole of Trypanosoma cruzi

Jiménez

Miranda

Augusto

2022

J Eukaryotic Microbiology

View full text Add to dashboard Cite

Osmoregulation is a conserved cellular process required for the survival of all organisms. In protists, the need for robust compensatory mechanisms that can maintain cell volume and tonicity within physiological range is even more relevant, as their life cycles are often completed in different environments. Trypanosoma cruzi, the protozoan pathogen responsible for Chagas disease, is transmitted by an insect vector to multiple types of mammalian hosts. The contractile vacuole complex (CVC) is an organelle that senses and compensates osmotic changes in the parasites, ensuring their survival upon ionic and osmotic challenges. Recent work shows that the contractile vacuole is also a key component of the secretory and endocytic pathways, regulating the selective targeting of surface proteins during differentiation. Here we summarize our current knowledge of the mechanisms involved in the osmoregulatory processes that take place in the vacuole, and we explore the new and exciting functions of this organelle in cell trafficking and signaling.

show abstract

The HOG pathway and the regulation of osmoadaptive responses in yeast

Cited by 48 publications

References 98 publications

Yeast osmoregulation – glycerol still in pole position

Yeast osmoregulation – glycerol still in pole position

Regulation of Conidiogenesis in Aspergillus flavus

The old and the new about the contractile vacuole of Trypanosoma cruzi

Contact Info

Product

Resources

About