This study investigated the relationship of homeless status, ethnic identity, respondent ethnicity (African American, Latino, Native American, and Anglo), and Latino, Anglo, and Mexican American orientation on the functional impairment (Behavior and Symptom Identification Scale, BASIS-32; S. V. Eisen, 1996) of 355 homeless men and women who were interviewed in Pomona, California. Multivariate analyses of variance results indicated that respondent ethnicity was related to several BASIS-32 subscales. Specifically, Anglo and African American homeless adults had greater functional impairment than did Latino or Native American respondents. In addition, high Anglo orientation among chronically homeless Latino respondents, with low ethnic identity was associated with higher levels of functional impairment on the BASIS-32 Psychosis subscale. The implications of these findings are discussed.