The Homozygous Hemoglobin EE Genotype and Chronic Inflammation Are Associated with High Serum Ferritin and Soluble Transferrin Receptor Concentrations among Women in Rural Cambodia

Karakochuk, Crystal D; Whitfield, Kyly C.; Rappaport, Aviva I; Barr, Susan I.; Vercauteren, Suzanne; McLean, J.; Sophonneary, Prak; Kroeun, Hou; Talukder, Aminuzzaman; Devenish, Robyn; Green, Timothy

doi:10.3945/jn.115.218636

Cited by 13 publications

(12 citation statements)

References 40 publications

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“…We found a large difference in estimated prevalence of ID based on sTfR and SF, even after 334 adjustment, which is consistent with findings of other studies (10,14,22,39,40). Since SF and 335 sTfR measure different aspects of iron status, differences in prevalence may not be surprising.…”

supporting

confidence: 80%

“…However, as previously mentioned in contrast to our results others have observed positive 322 relationships between inflammation markers and sTfR (10)(11)(12)(13)(14) or shown that that sTfR 323 decreased in malaria (8). In addition to increased erythropoiesis, higher sTFR concentrations 324 in children with infections may also be due to poorer iron status.…”

contrasting

confidence: 57%

“…sTfR 60 is believed to be less affected by inflammation (4), although there are discrepancies in the 61 literature regarding the relationship between inflammation, infection and sTfR. Some studies 62 have shown that sTfR decreased in presence of inflammation (6,7) and malaria (8) while others 63 found higher levels of sTfR in individuals with malaria (9,10) or observed positive 64 relationships between inflammation markers and sTfR (10)(11)(12)(13)(14). It is unclear what causes these Plasmodium falciparum malaria parasite (Bioline, Malaria Ag P.f, Standard diagnostics Inc.) 124 and one drop of blood was used to estimate haemoglobin concentration using a HemoCue 125 device (HB 301, Ängelholm, Sweden).…”

mentioning

confidence: 90%

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Assessment of Regression Models for Adjustment of Iron Status Biomarkers for Inflammation in Children with Moderate Acute Malnutrition in Burkina Faso

Cichon

Ritz

Fabiansen

et al. 2017

The Journal of Nutrition

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supporting

confidence: 80%

contrasting

confidence: 57%

mentioning

confidence: 90%

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Assessment of Regression Models for Adjustment of Iron Status Biomarkers for Inflammation in Children with Moderate Acute Malnutrition in Burkina Faso

Cichon

Ritz

Fabiansen

et al. 2017

The Journal of Nutrition

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“…Furthermore, menstrual blood loss, a determinant of iron stores in women of reproductive age [38], was not recorded. Inherited hemoglobin disorders are also known to impact on iron markers [27,39]. Recently, these effects were examined in a cross-sectional survey among 450 Cambodian women [39].…”

Section: Discussionmentioning

confidence: 99%

Nutritional and Micronutrient Status of Female Workers in a Garment Factory in Cambodia

et al. 2016

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Background: Concerns about the nutritional status of Cambodian garment workers were raised years ago but data are still scarce. The objectives of this study are to examine the nutritional, hemoglobin and micronutrient status of female workers in a garment factory in Phnom Penh, Cambodia, and to assess if body mass index is associated with hemoglobin and/or micronutrient status. Methods: A cross-sectional survey was conducted among 223 female workers (nulliparous, non-pregnant) at a garment factory in Phnom Penh. Anthropometric measurements were performed and blood samples were taken to obtain results on hemoglobin, iron, vitamin A, vitamin B12 and inflammation status (hemoglobinopathies not determined). Bivariate correlations were used to assess associations. Results: Overall, 31.4% of workers were underweight, 26.9% showed anemia, 22.1% showed iron deficiency, while 46.5% had marginal iron stores. No evidence of vitamin A or vitamin B12 deficiency was found. Body mass index was associated with serum ferritin (negative) and serum retinol-binding protein (positive) concentrations, but not strongly. A comparison between underweight and not underweight workers resulted in distinctions for iron deficiency and iron deficiency anemia, with a higher prevalence among not underweight. Conclusions: The prevalence of underweight, anemia and poor iron status was high. Young and nulliparous female garment workers in Cambodia might constitute a group with elevated risk for nutritional deficiencies. Strategies need to be developed for improving their nutritional, micronutrient and health status. The poor iron status seems to contribute to the overall prevalence of anemia. Low hemoglobin and iron deficiency affected both underweight and those not underweight. Despite the fact that body mass index was negatively associated with iron stores, true differences in iron status between underweight and not underweight participants cannot be confirmed.

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“…Lastly, we used Thurnham et al [19] correction factors to adjust for levels of inflammation in our populations studied. These correction factors were demonstrated to be accurate for use in the same Cambodian population of n = 420 women in this study (which also used the s-ELISA to measure the inflammation biomarkers used for adjustments) [27], however, the robustness of these correction factors for use with the other ferritin assays has not yet been established.…”

Section: Limitations Of Our Studymentioning

confidence: 99%

Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children

Karakochuk

Whitfield

Rappaport

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Global standardization of ferritin assays is lacking, which could have direct implications on the accurate measurement and comparability of ferritin concentration and iron deficiency (ID) prevalence rates in at-risk populations. Methods: We measured serum ferritin concentrations using four immunoassays: the s-ELISA and the AxSYM™ analyzer were compared among 420 non-pregnant Cambodian women; the Centaur ® XP analyzer, s-ELISA, and AxSYM™ analyzer were compared among a subset of 100 Cambodian women; and the s-ELISA and the Elecsys

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The Homozygous Hemoglobin EE Genotype and Chronic Inflammation Are Associated with High Serum Ferritin and Soluble Transferrin Receptor Concentrations among Women in Rural Cambodia

Abstract: Compared with sTfR, ferritin concentrations appear to reflect more accurately true ID in rural Cambodian women. The CFs from a published meta-analysis were appropriate for use in this population with a high prevalence of Hb disorders and inflammation.

Cited by 13 publications

References 40 publications

Assessment of Regression Models for Adjustment of Iron Status Biomarkers for Inflammation in Children with Moderate Acute Malnutrition in Burkina Faso

Assessment of Regression Models for Adjustment of Iron Status Biomarkers for Inflammation in Children with Moderate Acute Malnutrition in Burkina Faso

Nutritional and Micronutrient Status of Female Workers in a Garment Factory in Cambodia

Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children

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