The hope for pandora\'s box: mesenchymal stem cells (mscs) for promoting angiogenesis in stroke and trauma brain injury

Dong, Huajiang; Peng, Dingwei; Luo, Yuechen; Li, Rui; Yin, Huijuan; Wang, Lei; Sha, Hong; Wang, Ping; Shang, Chongzhi

doi:10.5137/1019-5149.jtn.23552-18.2

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Under the certain induction, the cells can differentiate into mesodermderived osteoblasts, chondrocytes and adipocytes, and also liver cells, heart cells and nerve cells (1)(2)(3)13,20,23,28,31,33). As demonstrated by in vitro studies, MSCs secrete various cell factors, for example, factor derived from matrix, hepatocyte growth factor, insulin-like growth factor, fibroblast growth factor, ischemia-induced factor, vascular endothelial stem cell transplantation, it exerts the immunomodulatory function via the secretion of autocrine and paracrine cytokines to promote angiogenesis in local ischemic tissue, while MSCs can integrate the damaged vascular plexus and then directly differentiate into mature new blood vessels (8,9,16).…”

Section: A B Cmentioning

confidence: 99%

Study on umbilical cord-matrix stem cells transplantation for treatment of acute trauma brain injury in rats

Wang

Peng²,

Yang³

et al. 2019

Turkish Neurosurgery

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AIM: To evaluate the effect of umbilical cord derived mesenchymal stem cells (UC-MSCs) transplantation on traumatic brain injury (TBI). MATERIAL and METHODS: UC-MSCs were isolated from human umbilical cord and TBI rat model was constructed. 30 male SD rats were randomly divided into 3 groups: control group, TBI group and MSCs transplantation group. Rats in MSCs group received the injection of a total of 1.5 × 106 MSCs (25 μl) via ventricle at operated ventricular coordinates (0 at bregma, 1.5 mm at lateral, 1.1 mm at behind, 4.5 mm in depth). RESULTS: 80% confluence of cells was formed from tissue at day 10 and the amount of CD90, CD73, CD105 positive cells increased correspondingly. In TBI model, clear hyperemia, edema and obvious infiltration of inflammatory cells in brain tissue were found. However, the manifestations were alleviated after the treatment of MSCs. In MSCs group, GFP in the brain tissue and the area around the vessels were found after the injection, while the expression levels of micro-vessel density (MVD), brain-derived neurotrophic factor (BDNF) and glial fibrillary acidic protein (GFAP) were elevated. CONCLUSION: UC-MSCs transplantation for treatment of acute TBI could effectively reduce the injury and improve the vascular reconstruction.

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