The hormonal status modulates the effect of neurokinin A on prolactin secretion in female rats

Pisera, Daniel; Theas, María Susana; Laurentiis, Andrea De; Lasaga, Mercedes; Duvilanski, Beatriz H.; Seilicovich, Adriana

doi:10.1677/joe.0.1590389

Cited by 9 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Candidate genes in this region (from BTA4.0; www.ensembl.org) include pyrophosphatase 2, tachykinin receptor 3, and mannosidase, β A. Both pyrophosphatase 2 and mannosidase are expressed in the mammary gland, and tachykinins have a role in modulating prolactin release during lactation (Pisera et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Genetic markers for lactation persistency in primiparous Australian dairy cows

Pryce¹,

Haile‐Mariam²,

Verbyla

et al. 2010

Journal of Dairy Science

View full text Add to dashboard Cite

Good performance in extended lactations of dairy cattle may have a beneficial effect on food costs, health, and fertility. Because data for extended lactation performance is scarce, lactation persistency has been suggested as a suitable selection criterion. Persistency phenotypes were calculated in several ways: P1 was yield relative to an approximate peak, P2 was the slope after peak production, and P3 was a measure derived to be phenotypically uncorrelated to yield and calculated as a function of linear regressions on test-day deviations of days in milk. Phenotypes P1, P2, and P3 were calculated for sires as solutions estimated from a random regression model fitted to milk yield. Because total milk yield, calculated as the sum of daily sire solutions, was correlated to P1 and P2 (r=0.30 and 0.35 for P1 and P2, respectively), P1 and P2 were also adjusted for milk yield (P1adj and P2adj, respectively). To find genomic regions associated with the persistency phenotypes, we used a discovery population of 743 Holstein bulls proven before 2005 and 2 validation data sets of 357 Holstein bulls proven after 2005 and 294 Jersey sires. Two strategies were used to search for genomic regions associated with persistency: 1) persistency solutions were regressed on each single nucleotide polymorphism (SNP) in turn and 2) a genomic selection method (BayesA) was used where all SNP were fitted simultaneously. False discovery rates in the validation data were high (>66% in Holsteins and >77% in Jerseys). However, there were 2 genomic regions on chromosome 6 that validated in both breeds, including a cluster of 6 SNP at around 13.5 to 23.7 Mbp and another cluster of 5 SNP (70.4 to 75.6 Mbp). A third cluster validated in both breeds on chromosome 26 (0.33 to 1.46 Mbp). Validating SNP effects across 2 breeds is unlikely to happen by chance even when false discovery rates within each breed are high. However, marker-assisted selection on these selected SNP may not be the best way to improve this trait because the average variation explained by validated SNP was only 1 to 2%. Genomic selection could be a better alternative. Correlations between genomic breeding values predicted using all SNP simultaneously and estimated breeding values based on progeny test were twice as high as the equivalent correlations between estimated breeding values and parent average. Persistency is a good candidate for genomic selection because the trait is expressed late in lactation.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic markers for lactation persistency in primiparous Australian dairy cows

Pryce¹,

Haile‐Mariam²,

Verbyla

et al. 2010

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…These ewes were long-term ovariectomized with no estrogen replacement. The induction of NK-1 receptors is estrogen dependent [41], and there is evidence that tachykinins may not affect prolactin release in the ovariectomized rat [42]. Second, SP is rapidly degraded [37], and a 70-nmol dose may not have been sufficient to raise SP levels in the hypophyseal portal system.…”

Section: Discussionmentioning

confidence: 99%

Substance P-Immunoreactive Cells in the Ovine Pars Tuberalis

et al. 2008

View full text Add to dashboard Cite

The pars tuberalis (PT) is a distinct subdivision of the anterior pituitary gland that plays a central role in regulating seasonal prolactin release. In sheep, there is compelling evidence that seasonal changes in light, transformed into a melatonin signal, are interpreted by the PT to modulate the release of a factor which affects prolactin release. The identity of this factor(s) is unknown but has been preemptively called ‘tuberalin’. In the present study, we report on an initial immunocytochemical investigation where we have identified that many ovine PT cells are immunoreactive for the tachykinin substance P (SP). Few cells in the pars distalis immunoreact for SP. The SP-immunoreactive cells did not colocalize with β-luteinizing hormone. RT-PCR confirmed the presence of preprotachykinin A mRNA in the PT. We hypothesize that SP, and possibly other preprotachykinin A-derived tachykinins, may play a role in the seasonal regulation of prolactin secretion in sheep.

show abstract

“…Intriguingly, SP-induced BP reduction was also mimicked by microinjection of NK1R and NK2R agonists with equal efficacy, but a long-lasting action was only observed in the presence of NK1R. These data imply that the NG plays an exact opposite role in BP regulation vs NTS and the protective role of estrogen-dependent NKRs expression in the NG and the sensitivity NKRs to SP 47 . Intriguing observations from our recent experiments and other cardiovascular literature have demonstrated that the difference in central and peripheral activation of neuropeptide Y mediates hypotensive 48 and hypertensive action.…”

Section: Ng Plays An Opposite Role In Bp Regulation Compared With That Of Ntsmentioning

confidence: 80%