The Dresden-Friedrichstadt hospital originated from Marcolini's summer palace. It was founded in 1845 and opened in 1849. It is a place where history and art of European importance mixes with technical and medical innovations. We reflect on the meetings of Napoleon Bonaparte and Metternich in 1812, the creation of the famous Neptune fountain by Longuelune and Matielli and two outstanding physicians of the 19 century, the surgeon Eduard Zeis, who coined the medical term "plastic surgery", and Maximilian Nitze, inventor of the first "modern" cystoscope and the father of urology.