The HoVert technique: a novel method for the sectioning of alopecia biopsies

Nguyen, Jennifer; Hudacek, Kristin D.; Whitten, Joseph A.; Rubin, Adam I.; Seykora, John T.

doi:10.1111/j.1600-0560.2010.01669.x

Cited by 54 publications

(42 citation statements)

References 12 publications

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“…The best approach is to use protocols that combine both horizontal and vertical sections (Fig. 9), [49][50][51][52] in association with good clinicopathological correlation. It is also important that the reporting pathologist/dermatopathologist is experienced in the interpretation of hair and scalp biopsies.…”

Section: Investigationsmentioning

confidence: 99%

Hair and scalp disorders in women of African descent: an overview

2013

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Section: Investigationsmentioning

confidence: 99%

Hair and scalp disorders in women of African descent: an overview

2013

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“…This overcomes the limitation of multiple scalp biopsies [ Figure 11]. [80] Based upon the histopathological picture, the CAs are divided mainly into lymphocyte-mediated primary cicatricial alopecia (LMPCA), neutophil-mediated primary cicatricial alopecia (NMPCA), and mixed CA [ Table 1]. [7,81,82] The diseases clubbed under LMPCA (LPP, FFA, DLE, CCCA, PPB) are typified by a lymphocyte rich infiltrate in early stages and with variable but limited fibrosis concentrated in the perifollicular adventitial unit in later stages.…”

Section: Histopathologymentioning

confidence: 99%

What′s new in cicatricial alopecia?

Dogra¹,

Sarangal²

2013

Indian J Dermatol Venereol Leprol

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Scalp hairs complete the body self-image and patients with alopecia suffer from overt disfiguration, leading to psychosocial embarrassment and significant lack of self-esteem. Hence an early diagnosis and an aggressive treatment in the case of active hair loss are crucial in the management of scarring alopecia. This review presents a comprehensive study of newer theories in aetiopathogenesis, evolving diagnostic modalities and a step ladder approach in management of primary cicatricial alopecia.

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“…4). 7,19 However, multiple biopsies could burden the patients with greater medical costs and morbidity 20 . Recently, the “HoVert” technique, a novel processing technique which produces transverse (horizontal) and vertical sections from a single biopsy, was described (Fig.…”

Section: Advances In Diagnostic Proceduresmentioning

confidence: 99%

Primary cicatricial alopecia: Recent advances in understanding and management

Ohyama

2011

The Journal of Dermatology

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Primary cicatricial alopecias (PCA) are a rare group of disorders, in which the hair follicle is the main target of destructive inflammation resulting in irreversible hair loss with scarring of affected lesions. The most typical clinical manifestation of PCA is the loss of visible follicular ostia. The histopathological hallmark of a fully developed lesion is the replacement of the hair follicle structure by fibrous tissue. PCA could share similar clinical manifestations and eventually lead to ''burnout'' alopecia. Some subsets are hardly distinguishable histopathologically and the mechanisms that elicit such a destructive reaction have not been fully elucidated. Thus, the management of PCA represents one of the most challenging clinical problems for dermatologists. The aim of this review is to provide a concise and comprehensive summary of recent advances in PCA management, especially focusing on novel methodologies to aid diagnosis, and updates on our understanding of the etiopathogenesis. Dermoscopy, a new pathological preparation technique and direct immunofluorescence analysis enable more accurate clinicopathological diagnosis of PCA. Microarray analysis may be beneficial to distinguish PCA subtypes. Currently suggested mechanisms underlying PCA include loss of immune protection of stem cells, impaired stem cell self-maintenance, enhanced autoimmunity by pro-inflammatory cytokines and environmental ⁄ genetic predispositions. Interestingly, recent data indicates the association between lipid metabolism dysregulation and PCA development, implying an important role of the sebaceous gland dysfunction in the etiopathogenesis. Based on that hypothesis and observations, novel therapeutic approaches have been proposed, including the use of peroxisome proliferator-activated receptor-c agonist for lichen planopilaris.

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The HoVert technique: a novel method for the sectioning of alopecia biopsies

Abstract: We believe that the HoVert technique represents a simple and diagnostically effective tool in differentiating LPP from DLE. It may also be applicable to the assessment of other forms of alopecia.

Cited by 54 publications

References 12 publications

Hair and scalp disorders in women of African descent: an overview

Hair and scalp disorders in women of African descent: an overview

What′s new in cicatricial alopecia?

Primary cicatricial alopecia: Recent advances in understanding and management

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