The HPA axis and cocaine reinforcement

Goeders, Nicholas E.

doi:10.1016/s0306-4530(01)00034-8

Cited by 196 publications

(174 citation statements)

References 84 publications

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“…The contribution of high cortisol levels to the maintenance of smoking behavior is unclear, but decreases in cortisol on the first day of smoking abstinence were associated with a higher rate of relapse during the first week (al 'Absi et al, 2004). The importance of cortisol for the reinforcing effects of cocaine has been clearly demonstrated in rodents (Goeders, 2002a).…”

Section: Subjective Responses To Smoking High-and Low-nicotine Cigarementioning

confidence: 99%

“…cocaine self-administration by rats (Goeders and Guerin, 2000). The possible influence of HPA axis activation, as indicated by ACTH and cortisol increases, on the abuserelated effects of cocaine has been discussed in several reviews (Goeders, 1997(Goeders, , 2002aMello and Mendelson, 2002). The similar patterns of HPA axis activation and subjective responses after i.v.…”

Section: Subjective Responses To Smoking High-and Low-nicotine Cigarementioning

confidence: 99%

“…HPA axis activation is also a response to 'stress' variously defined, and there has been considerable interest in the relationship between 'stress' and vulnerability to drug addiction (Koob and Le Moal, 2001;Sinha, 2001;Grammatopoulos and Chrousos, 2002;Marinelli and Piazza, 2002;Heinrichs and Koob, 2004), as well as other psychiatric disorders (see for review Chrousos, 1994, 2002). HPA axis hormones, as well as gonadal steroid hormones, appear to influence some behavioral responses to cocaine (Goeders, 1997(Goeders, , 2002aMello and Mendelson, 2002). Studies of the generality of these findings to women at the follicular and luteal phases of the menstrual cycle are in progress (Mendelson et al, 2004).…”

Section: Subjective Responses To Smoking High-and Low-nicotine Cigarementioning

confidence: 99%

“…Several lines of evidence suggest that stimulation of CRH, as indicated by increases in ACTH and cortisol, may contribute to the reinforcing effects of cocaine (Goeders, 1997(Goeders, , 2002aMello and Mendelson, 2002;Mendelson et al, 2002). For example, the adrenal hormone corticosterone is critically important for the acquisition and maintenance of cocaine self-administration in rats (Goeders and Guerin, 1996;Mantsch et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Low- and High-Nicotine Cigarette Smoking on Mood States and the HPA Axis in Men

Mendelson

Sholar

Goletiani

et al. 2005

Neuropsychopharmacol

125

106

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The acute effects of smoking a low-or high-nicotine cigarette on hypothalamic-pituitary-adrenal (HPA) hormones, subjective responses, and cardiovascular measures were studied in 20 healthy men who met American Psychiatric Association Diagnostic and Statistical Manual IV criteria for nicotine dependence. Within four puffs (or 2 min) after cigarette smoking began, plasma nicotine levels and heart rate increased significantly (Po0.01), and peak ratings of 'high' and 'rush' on a Visual Analogue Scale were reported. Reports of 'high,' 'rush,' and 'liking' and reduction of 'craving' were significantly greater after smoking a high-nicotine cigarette than a low-nicotine cigarette (Po0.05). Peak plasma nicotine levels after high-nicotine cigarette smoking (23.972.6 ng/ml) were significantly greater than after lownicotine cigarette smoking (3.6370.59 ng/ml) (Po0.001). After smoking a low-nicotine cigarette, adrenocorticotropin hormone (ACTH), cortisol, dehydroepiandrosterone (DHEA), and epinephrine did not change significantly from baseline. After high-nicotine cigarette smoking began, plasma ACTH levels increased significantly above baseline within 12 min and reached peak levels of 21.8875.34 pmol/l within 20 min. ACTH increases were significantly correlated with increases in plasma nicotine (r ¼ 0.85; Po0.0001), DHEA (r ¼ 0.66; P ¼ 0.002), and epinephrine (r ¼ 0.86; Po0.0001). Cortisol and DHEA increased significantly within 20 min (Po0.05) and reached peak levels of 424748 and 21.1372.55 ng/ml within 60 and 30 min, respectively. Thus cigarette smoking produced nicotine dose-related effects on HPA hormones and subjective and cardiovascular measures. These data suggest that activation of the HPA axis may contribute to the abuse-related effects of cigarette smoking.

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Section: Subjective Responses To Smoking High-and Low-nicotine Cigarementioning

confidence: 99%

Section: Subjective Responses To Smoking High-and Low-nicotine Cigarementioning

confidence: 99%

Section: Subjective Responses To Smoking High-and Low-nicotine Cigarementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Low- and High-Nicotine Cigarette Smoking on Mood States and the HPA Axis in Men

Mendelson

Sholar

Goletiani

et al. 2005

Neuropsychopharmacol

125

106

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“…Intermittent exposures to environmental stress can amplify many physiological and behavioral responses to psychomotor stimulants and can accelerate the initiation and maintenance of cocaine use (Miczek and Mutschler, 1996;Goeders, 2002;Sinha, 2001). In particular, brief exposure to social stress increases the rate of acquiring cocaine selfadministration (Haney et al, 1995;Tidey and Miczek, 1997;Kabbaj et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Brief Social Defeat Stress: Long Lasting Effects on Cocaine Taking During a Binge and Zif268 mRNA Expression in the Amygdala and Prefrontal Cortex

Covington

Kikusui

Goodhue

et al. 2004

Neuropsychopharmacol

112

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Social stress can engender behavioral and neural sensitization and this process appears to enhance the transition to compulsive drug abuse. Exposures to brief social defeat stress in rats have significant consequences on cocaine-reinforced behavior and on the level of functional activation within regions of the mesocorticolimbic dopamine system. The objectives of the current study were to examine the enduring consequences of brief episodes of social defeat stress on cocaine bingeing (during 24 h of continuous access) and on the emergence of neural adaptations as revealed by zif268 immediate early gene expression. Adult, male Long-Evans rats were subjected to four 25 min episodes of social defeat (once every 72 h). After 2 months, cocaine binges or zif268 mRNA gene expression were studied after confirming behavioral cross-sensitization to stimulant challenge. Sensitization to social defeat increased cocaine intake during a 24 h binge, effectively abolishing the typical circadian pattern of intake. Furthermore, 60 days after exposure to the sensitizing regimen of social defeat, levels of functional activation, measured by zif268 mRNA expression, in the central and medial amygdala were increased, while levels of activation in the medial prefrontal cortex were decreased. Persistent stress-induced levels of zif268 in the central and medial amygdala were attenuated by an injection of amphetamine (1.0 mg/kg). Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants.

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Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes

Sinha¹,

García²,

Paliwal³

et al. 2006

Arch Gen Psychiatry

488

388

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These results demonstrate that stress-related increases in cocaine craving and hypothalamic-pituitary-adrenal axis responses are each associated with specific cocaine relapse outcomes. The findings support the use of stress-induced drug craving and associated hypothalamic-pituitary-adrenal axis responses to evaluate cocaine relapse propensity. Furthermore, treatments that address stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses could be of benefit in improving relapse outcomes in cocaine dependence.

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The HPA axis and cocaine reinforcement

Cited by 196 publications

References 84 publications

Effects of Low- and High-Nicotine Cigarette Smoking on Mood States and the HPA Axis in Men

Effects of Low- and High-Nicotine Cigarette Smoking on Mood States and the HPA Axis in Men

Brief Social Defeat Stress: Long Lasting Effects on Cocaine Taking During a Binge and Zif268 mRNA Expression in the Amygdala and Prefrontal Cortex

Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes

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