The Hsp90 chaperone complex-A potential target for cancer therapy

Darimont, Beatrice

doi:10.3748/wjg.v5.i3.195

Cited by 9 publications

(3 citation statements)

References 59 publications

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“…The existence of mutant or abnormal proteins also stimulates HSPs synthesis [6][7][8][9] . Heat shock proteins can maintain oncogene products in inactive state [10] .…”

Section: Discussionmentioning

confidence: 99%

Significance of expression of heat shock protein90α in human gastric cancer

Zuo¹,

Dai²,

Ai-hua³

et al. 2003

WJG

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AIM:To evaluate the significance of hsp90α expression in human gastric cancer tissues.METHODS: lmmunohistochemical staining was used in clinical specimens from 33 cases of gastric cancer and 33 cases of gastritis with rabbit anti-human hsp90α multi-clonal antibody in order to explore the relationship between the expression of hsp90α in gastric carcinoma tissue and gastritis tissue as well as in mucous membrane adjacent to cancer and lymph node metastasis. RESULTS:Hsp90α was detected in 88 % of gastric carcinoma cases and 55 % of gastritis cases. The hsp90α positive rate in gastric cancer group was significantly higher than that in gastritis group (P<0.01, P=0.005). The hsp90α positive rate in gastric cancer and in mucous membrane adjacent to cancer was 88 % and 55 % respectively (P<0.01,P=0.005). The hsp90α positive rate in lymph node metastasis group and non-lymph node metastasis group was 100 % and 60 % respectively, and a significant correlation between hsp90α expression and lymph node metastasis was shown (P<0.01, P=0.005). CONCLUSION:The hsp90α expression rate in gastric cancer group was significantly higher than that in gastritis group as well as that in the group of mucous membrane adjacent to cancer. The hsp90α expression in lymphatic node metastasis group was higher than that in non-lymphatic node metastasis group. The results indicate that increased hsp90α expression has a close relationship with occurrence and lymph node metastasis of gastric cancer.Zuo DS, Dai J, Bo AH, Fan J, Xiao XY. Significance of expression of heat shock protein90α in human gastric cancer. World J Gastroenterol 2003; 9(11): 2616-2618

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“…The existence of mutant or abnormal proteins also stimulates HSPs synthesis [6][7][8][9] . Heat shock proteins can maintain oncogene products in inactive state [10] .…”

Section: Discussionmentioning

confidence: 99%

Significance of expression of heat shock protein90α in human gastric cancer

Zuo¹,

Dai²,

Ai-hua³

et al. 2003

WJG

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“…More than 10 differentially expressed genes were found in total 588 genes, most of these were digestive enzyme related genes, one of the overexpression gene was inducible heat shock protein 70 gene [20] . A variety of chemicals, viruses, and noxious stimuli such as trauma, hypoxia, or ischemia trigger the heat shock response and the subsequent synthesis of heat shock proteins [35][36][37][38][39][40][41][42][43] . The results of our experiment indicated that sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats, which was confirmed by RT-PCR, Western blotting and immunostaining.…”

Section: Discussionmentioning

confidence: 99%

Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa

Shen¹

2001

WJG

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AIM To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense.METHODS Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol (500mL·L -1 , i.g.) was used to induce gastric mucosa damage.RESULTS RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL·L -1 ethanol challenge, the ulcer area found in the rats with 7d sleep deprivation (19.15±4.2)mm 2 was significantly lower (P<0.01) than the corresponding control (53.7± 8.1) mm 2 .CONCLUSION Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection. Subject headingssleep deprivation; heat shock proteins 70/biosynthesis; gastric mucosa; rats Shen XZ, Koo MWL, Cho CH. Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa. World J Gastroenterol, 2001;7(4):496-499

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“…Under exposure to different kinds of environmental stressors, HSP90 expression increases in order to repair and stabilize damaged proteins such as oncoproteins involved in cancer cell growth. Upregulation of HSP90 is hypothesized to delay or prevent cells from entering the apoptotic pathway, which could account for the involvement of HSP90 in tumorigenesis and resistance to chemotherapy [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Serum heat shock protein 90 as a future predictive biomarker in childhood acute lymphoblastic leukemia

Pawlik-Gwozdecka¹,

Górska‐Ponikowska²,

Adamkiewicz-Drożyńska³

et al. 2021

cejoi

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Heat shock proteins (HSPs) attract the attention of scientists and clinicians due to their potential role as diagnostic and prognostic factors in a variety of cancers. HSP90 is one of the most important and well-known family members, necessary for maintaining intracellular homeostasis. In the extracellular space, it is responsible for the transmission of alarm signals to the immune system. Numerous reports have indicated that the level of intra - and extracellular HSP90 can correlate either with a poorer prognosis or with a better outcome, depending on the type of cancer. Still, little is known why the level of this chaperone is increased in some tumors and decreased in others, reflecting dual role of protein in cell death processes. Currently, there is no database reporting levels of serum HSP90 in children with acute lymphoblastic leukemia (ALL). As such, using enzyme-linked immunosorbent assay (ELISA) method, we aimed to determine this parameter in a group of 21 patients with newly diagnosed ALL. We found decreased protein serum levels in patients at disease presentation and after induction block of chemotherapy in comparison to healthy controls. Furthermore, we observed a negative correlation between HSP90 serum levels and one of the earliest prognostic factors of the treatment response – peripheral blood lymphoblasts on the 8 th day of treatment. Our results indicate that HSP90 serum may play an important role in leukemogenesis and could be used as a marker to predict treatment failure in children with ALL.

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The Hsp90 chaperone complex-A potential target for cancer therapy

Cited by 9 publications

References 59 publications

Significance of expression of heat shock protein90α in human gastric cancer

Significance of expression of heat shock protein90α in human gastric cancer

Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa

Serum heat shock protein 90 as a future predictive biomarker in childhood acute lymphoblastic leukemia

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