The Hudson River: A Case Study of PCB Contamination

Carpenter, David O.; Welfinger‐Smith, Gretchen

doi:10.1002/9781118148594.ch25

Cited by 4 publications

(3 citation statements)

References 181 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result the profile of PCB congeners in the vapor phase is significantly different from the parent mixture. Carpenter and Welfinger‐Smith (2010) have demonstrated this by passing air over pure Aroclor 1260, a highly chlorinated mixture, and found that lower chlorinated congeners that are not even apparent in the pure Aroclor appear in the vapor phase in high concentration (their Fig. 3).…”

Section: Discussionmentioning

confidence: 99%

PCB 9 exposure induces endothelial cell death while increasing intracellular calcium and ROS levels

Yılmaz

Sandal

Carpenter

2011

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

Cultured porcine endothelial cells were used to determine the effects of several congeners of polychlorinated biphenyls (PCBs) on cell viability and changes induced by these congeners on levels of intracellular calcium and reactive oxygen species (ROS). Cultured endothelial cells were prepared as a single suspension and run on flow cytometry. Cell viability, intracellular calcium, and ROS concentrations were simultaneously determined by using propidium iodide, Fluo-3, and dihydrorodamine, respectively. The congeners tested included two coplanar tetrachlorinated congeners that have no ortho chlorines, PCBs 77 and 80, a tri-chloro congener which does not have any ortho chlorine, PCB 39, a di-ortho, tetrachlorinated congener, PCB 52, and a mono-ortho congener, PCB 9. PCB 9 was cytotoxic at 5 μM within 5 min of exposure, and the toxicity increased with time and concentration. None of the other congeners showed consistent cytotoxicity. The cytotoxicity was roughly correlated with elevations in cellular ROS levels, but not with changes in intracellular calcium. To the best of our knowledge, toxicity of lower chlorinated, more volatile congeners such as PCB 9 has not been previously studied. These observations may be taken to explain the elevated risk of cardiovascular disease previously reported among residents living near to hazardous waste sites containing PCBs.

show abstract

Section: Discussionmentioning

confidence: 99%

PCB 9 exposure induces endothelial cell death while increasing intracellular calcium and ROS levels

Yılmaz

Sandal

Carpenter

2011

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…This was a good solution to the explosion problem because PCBs were not flammable and were chemically stable. Unfortunately, some of the PCBs used at these GE plants leaked into the Hudson River, where they accumulated in the sediment. , PCBs were first detected in fish from the river in 1969, but the extent of the problem was not realized until the mid-1970s. In 1976, the passage of the Toxic Substance Control Act (ToSCA) brought an end to GE’s discharge of PCBs into the river, but it was eventually estimated by the U.S. EPA that as much as 600 t of PCBs had been discharged by GE over the 30 years from 1947 to 1977 .…”

Section: Hudson Falls and Fort Edward New Yorkmentioning

confidence: 99%

“…Most of this contamination by PCBs ended up in the river’s sediment, where it was biologically available to various species of fish (particularly bottom-dwellers such as carp). , PCB contamination levels in these fish were substantially higher than the U.S. EPA’s health guidelines, and the consumption of these fish was banned, a restriction that had a significant economic impact on several communities along the Hudson. Commercial fishing from the river was no longer allowed, and recreational fishing was discouraged.…”

Section: Hudson Falls and Fort Edward New Yorkmentioning

confidence: 99%

The Last Paper by Ron Hites. A Tale of Four Cities: Polychlorinated Biphenyls in America

Hites,

Venier

2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Polyhalogenated Biphenyls

2023

View full text Add to dashboard Cite

This chapter is intended to provide a detailed weight of evidence scientific review on polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs). Notably, PCBs are among the most thoroughly studied chlorinated persistent organic pollutants to date; despite their discontinued commercial production in the 1970s, their environmental persistence and widespread distribution continue to garner research attention regarding potential impacts on human health. Due to the voluminous literature pertaining to exposure and toxicology of PCBs, for practical purposes, this chapter was written to capture the scientific highlights of greatest import with respect to knowledge on exposures and toxicological properties of these compounds.

show abstract

The Hudson River: A Case Study of PCB Contamination

Cited by 4 publications

References 181 publications

PCB 9 exposure induces endothelial cell death while increasing intracellular calcium and ROS levels

PCB 9 exposure induces endothelial cell death while increasing intracellular calcium and ROS levels

The Last Paper by Ron Hites. A Tale of Four Cities: Polychlorinated Biphenyls in America

Polyhalogenated Biphenyls

Contact Info

Product

Resources

About