The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

Tannin, Grace M.; Agarwal, Anil K.; Monder, Carl; New, Maria I.; White, Perrin C.

doi:10.1016/s0021-9258(18)55351-5

Cited by 399 publications

(24 citation statements)

References 41 publications

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“…C/EBPδ is a member of the CEBP family which comprises six members of basic leucine zipper transcription factors known as C/EBPα, β, δ, γ, ε, and ζ. 39 In silico analysis shows that the core promoter regions of both HSD11B1 and PTGS2, the genes encoding 11β-HSD1 and COX-2, respectively, harbor the binding sites for C/EBPs, 40,41 and the expression of both 11β-HSD1 and COX-2 has been shown to be subject to the regulation by C/EBP family members in a number of cell types. [31][32][33][34][41][42][43] In order to investigate whether C/EBPδ is the transcription factor driving both 11β-HSD1 and COX-2 expression under the control of known factors involved in the onset of labor in the amnion, we first examined gestational and labor-induced changes of C/EBPδ in human amnion.…”

Section: Significance Statementmentioning

confidence: 99%

C/EBPδ drives key endocrine signals in the human amnion at parturition

Wang

Zhou

et al. 2021

Clinical & Translational Med

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Amnion‐derived prostaglandin E2 (PGE2) and cortisol are key to labor onset. Identification of a common transcription factor driving the expression of both cyclooxygenase‐2 (COX‐2) and 11β‐hydroxysteroid dehydrogenase 1 (11β‐HSD1), the key enzymes in their production, may hold the key to the treatment of pre‐term labor. Here, we have found that the CCAAT enhancer binding protein δ (C/EBPδ) is such a transcription factor which underlies the feed‐forward induction of COX‐2 and 11β‐HSD1 expression by their own products PGE2 and cortisol in human amnion fibroblasts so that their production would be ensured in the amnion for the onset of labor. Moreover, the abundance of C/EBPδ in the amnion increases along with COX‐2 and 11β‐HSD1 at term and further increases at parturition. Knockout of C/EBPδ in mice delays the onset of labor further supporting the concept. In conclusion, C/EBPδ pathway may be speculated to serve as a potential pharmaceutical target in the amnion for treatment of pre‐term labor.

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Section: Significance Statementmentioning

confidence: 99%

C/EBPδ drives key endocrine signals in the human amnion at parturition

Wang

Zhou

et al. 2021

Clinical & Translational Med

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“…884 Human 11 -HSD has been cloned. 885 Licorice is a well known inhibitor of 11 -HSD 886 and other enzymes. 887 The metabolism of cortisol also involves cortisol 4 -5 -reductase, dihydrocortisol-3 -oxidoreductase 888 and possibly cortisol 6 -hydroxylase.…”

Section: Biosynthesis Of Steroidal Hormones In Vertebratesmentioning

confidence: 99%

The biosynthesis of steroids and triterpenoids

Brown¹

1998

Nat. Prod. Rep.

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“…shown to be a bi-directional enzyme, capable to carry out both reductase and dehydrogenase activity (57). 11β-HSD1and 2 are encoded by two different genes, HSD11B1 (located on chromosome 1) and HSD11B2 (located on chromosome 16), sharing only 21% homology (58,59). The expression of the two enzymes is tissue specific, a feature that plays a crucial role in regulating both glucocorticoid and mineralocorticoid receptor activation.…”

Section: Interconversion Between Active and Inactive Glucocorticoidsmentioning

confidence: 99%