The human inferior parietal cortex: Cytoarchitectonic parcellation and interindividual variability

Caspers, Svenja; Geyer, Stefan; Schleicher, Axel; Mohlberg, Hartmut; Amunts, Katrin; Zilles, Karl

doi:10.1016/j.neuroimage.2006.06.054

Cited by 598 publications

(614 citation statements)

References 18 publications

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“…The more rostral (i.e., over area PF) and more caudal (i.e., over area PG) tDCS sites most likely resulted in a stimulation with emphasis on the supramarginal gyrus or the angular gyrus (and possibly other brain regions). This suggestion is consistent with neuropsychological and neuroimaging studies implicating both the supramarginal (Hermsdörfer et al, 2001;Decety et al, 2002;Mühlau et al, 2005) and the angular gyrus (Goldenberg and Hagmann, 1997;Rumiati et al, 2005) in human gesture processing (Tessari et al, 2007;Dovern et al, 2011;Mengotti et al, 2012). Therefore, at present, the most parsimonious interpretation of our tDCS data in the light of previous functional imaging studies is that both parts of the left IPL have to be stimulated simultaneously by anodal tDCS to facilitate matching of hand gestures in healthy subjects.…”

Section: Discussionsupporting

confidence: 72%

“…The need for neuronavigation is likely to be increased when the stimulated brain region (here: the parietal cortex) exhibits a complex organization with many functionally specific subregions (Grefkes and Fink, 2005). The issue is further complicated when this anatomical/functional subspecialization is not reflected in (macro)anatomical landmarks (Mars et al, 2011) and/or shows a large interindividual variability (Caspers et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…2). However, as the IPL constitutes a mosaic of different functional areas (i.e., the cytoarchitectonically defined areas PF, PFm, and PG) whose borders are not reflected by macroanatomical landmarks (Mars et al, 2011) and show high interindividual variability (Caspers et al, 2006), we used SPM and the Anatomy toolbox (Anatomy toolbox V 1.7 using the map "All Areas_v17_MPM.mat"; Eickhoff et al, 2005) to determine the location of the stimulation site with respect to the cytoarchitectonically defined maximum probability maps (MPMs) of IPL-areas PF, PFm, and PG. To this aim, the coordinates of the stimulation site (based on neuronavigation and macroanatomical landmarks; Fig.…”

Section: Methodsmentioning

confidence: 99%

“…As neuropsychological and neuroimaging studies implicate different subareas of the left IPL in human gesture processing, either the left supramarginal gyrus (Hermsdörfer et al, 2001;Decety et al, 2002;Mühlau et al, 2005) or the left angular gyrus (Goldenberg and Hagmann, 1997;Rumiati et al, 2005), we applied frameless stereotactic neuronavigation in healthy participants (n ϭ 26) to center tDCS over the three cytoarchitectonically defined areas PF, PFm, or PG of the left IPL. Thus, tDCS was focused on the left supramarginal gyrus (tDCS over PF), on the left angular gyrus (tDCS over PG), or on both gyri (tDCS over PFm) to assess possible neuroanatomically specific tDCS effects.…”

Section: Introductionmentioning

confidence: 99%

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Transcranial Direct Current Stimulation (tDCS) of Left Parietal Cortex Facilitates Gesture Processing in Healthy Subjects

et al. 2013

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Gesture processing deficits constitute a key symptom of apraxia, a disorder of motor cognition frequently observed after left-hemispheric stroke. The clinical relevance of apraxia stands in stark contrast to the paucity of therapeutic options available. Transcranial direct current stimulation (tDCS) is a promising tool for modulating disturbed network function after stroke. Here, we investigate the effect of parietal tDCS on gesture processing in healthy human subjects. Neuropsychological and imaging studies suggest that the imitation and matching of hand gestures involve the left inferior parietal lobe (IPL). Using neuronavigation based on cytoarchitectonically defined anatomical probability maps, tDCS was applied over left IPL-areas PF, PFm, or PG in healthy participants (n ϭ 26). Before and after tDCS, subjects performed a gesture matching task and a person discrimination task for control. Changes in error rates and reaction times were analyzed for the effects of anodal and cathodal tDCS (compared with sham tDCS). Matching of hand gestures was specifically facilitated by anodal tDCS applied over the cytoarchitectonically defined IPL-area PFm, whereas tDCS over IPL-areas PF and PG did not elucidate significant effects. Taking into account tDCS electrode size and the central position of area PFm within IPL, it can be assumed that the observed effect is rather the result of a combined stimulation of the supramarginal and angular gyrus than an isolated PFm stimulation. Our data confirm the pivotal role of the left IPL in gesture processing. Furthermore, anatomically guided tDCS of the left IPL may constitute a promising approach to neurorehabilitation of apraxic patients with gesture processing deficits.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcranial Direct Current Stimulation (tDCS) of Left Parietal Cortex Facilitates Gesture Processing in Healthy Subjects

et al. 2013

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“…1). This analysis identified a network of regions that comprised the supramarginal gyrus [assigned to parietal area PF with 70% probability (Caspers et al, 2006;Eickhoff et al, 2005)], supplementary motor area and the central sulcus, encompassing both the precentral gyrus (assigned to area 3b with 60% probability) and postcentral gyrus [assigned to area 1 with 70% probability (Geyer, Schleicher, & Zilles, 1999)]. The precise anatomical localization of these clusters is provided in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Altered connectivity between prefrontal and sensorimotor cortex in conversion paralysis

2010

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a b s t r a c tConversion paralysis (CP) is a frequent and impairing psychiatric disorder, affecting voluntary motor function. Yet, we have previously shown that the motor system of CP patients with a unilateral conversion paresis is recruited to a similar degree during imagined movements of the affected and unaffected limb. In contrast, imagery of movements with the affected limb results in larger prefrontal activation. It remains unclear how this hand-specific increased prefrontal activity relates to the reduced responsiveness of motor and somatosensory areas, a consistent and important feature of CP patients.In the current study, we investigated changes in the inter-regional coupling between prefrontal cortex (PFC) and sensorimotor regions when CP patients imagined movements involving either the affected or the unaffected hand. We found that there were distinct connectivity patterns for different parts of the PFC. While ventromedial PFC was not functionally connected to the motor system, we observed strong functional coupling between the dorsolateral PFC and various sensorimotor areas. Furthermore, this coupling was modulated by whether patients imagined movements of their affected or unaffected hand. Together, these results suggest that the reduced motor responsitivity observed in CP may be linked to altered dorsolateral prefrontal-motor connectivity.

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Episodic Memory in Healthy Older Adults

Rajah¹,

Maillet²,

Grady³

2015

The Wiley Handbook on the Cognitive Neuroscience of Memory

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The human inferior parietal cortex: Cytoarchitectonic parcellation and interindividual variability

Cited by 598 publications

References 18 publications

Transcranial Direct Current Stimulation (tDCS) of Left Parietal Cortex Facilitates Gesture Processing in Healthy Subjects

Transcranial Direct Current Stimulation (tDCS) of Left Parietal Cortex Facilitates Gesture Processing in Healthy Subjects

Altered connectivity between prefrontal and sensorimotor cortex in conversion paralysis

Episodic Memory in Healthy Older Adults

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