The human melanocyte and melanoblast populations per unit area of epidermis in the rete ridge are greater than in the inter‐rete ridge

Hirobe, Tomohisa; Enami, Hisao; Nakayama, Ai

doi:10.1111/ics.12682

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…Most likely, the absence of physical forces and mechanical stretching in healing skin could explain the absence of these structures 40 . Interestingly, the lack of these dermo‐epidermal specialized structures could explain the paucity of melanocytes in the grafted skin, since it has been recently demonstrated that the human skin melanoblast populations found at the rete ridge are greater than in the flat areas of the skin 41 …”

Section: Discussionmentioning

confidence: 99%

“…40 Interestingly, the lack of these dermo-epidermal specialized structures could explain the paucity of melanocytes in the grafted skin, since it has been recently demonstrated that the human skin melanoblast populations found at the rete ridge are greater than in the flat areas of the skin. 41 Once the epidermis and basement membrane were analyzed, we carried out specific analyses of the dermal layer. The human skin dermis mainly consists of a dense ECM containing several cell types, especially fibroblasts, and numerous blood and lymphatic vessels, and its function is crucial for the development and function of the suprajacent epidermis.…”

Section: Discussionmentioning

confidence: 99%

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Histological assessment of nanostructured fibrin‐agarose skin substitutes grafted in burnt patients. A time‐course study

Martín-Piedra

Carmona

Campos

et al. 2023

Bioengineering & Transla Med

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A previously developed fibrin‐agarose skin model—UGRSKIN—showed promising clinical results in severely burnt patients. To determine the histological parameters associated to the biocompatibility and therapeutic effects of this model, we carried out a comprehensive structural and ultrastructural study of UGRSKIN grafted in severely burnt patients after 3 months of follow‐up. The grafted epidermis was analogue to native human skin from day 30th onward, revealing well‐structured strata with well‐differentiated keratinocytes expressing CK5, CK8, CK10, claudin, plakoglobin, filaggrin, and involucrin in a similar way to controls, suggesting that the epidermis was able to mature and differentiate very early. Melanocytes and Langerhans cells were found from day 30th onward, together with a basement membrane, abundant hemidesmosomes and lack of rete ridges. At the dermal layer, we found an interface between the grafted skin and the host tissue at day 30th, which tended to disappear with time. The grafted superficial dermis showed a progressive increase in properly‐oriented collagen fibers, elastic fibers and proteoglycans, including decorin, similarly to control dermis at day 60‐90th of in vivo follow‐up. Blood vessels determined by CD31 and SMA expression were more abundant in grafted skin than controls, whereas lymphatic vessels were more abundant at day 90th. These results contribute to shed light on the histological parameters associated to biocompatibility and therapeutic effect of the UGRSKIN model grafted in patients and demonstrate that the bioengineered skin grafted in patients is able to mature and differentiate very early at the epithelial level and after 60–90 days at the dermal level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histological assessment of nanostructured fibrin‐agarose skin substitutes grafted in burnt patients. A time‐course study

Martín-Piedra

Carmona

Campos

et al. 2023

Bioengineering & Transla Med

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“…The inter-follicular epidermis of mice is generally flat, whereas that of humans is wavy and rich in rete ridges (9). Although the differences in the functions between the rete ridge epidermis and inter-rete ridge epidermis are not known, melanoblasts/melanocytes located in the rete ridge epidermis are more numerous than in the inter-rete ridge epidermis (10), suggesting the possibility that melanocytes present in the rete ridge epidermis contribute more greatly to the protection against UV.…”

Section: Contextmentioning

confidence: 99%

Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin

Hirobe

2023

J Skin Stem Cell

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Context: Functions of melanocytes are supported by many growth factors and cytokines derived from epidermal and dermal cells, especially keratinocytes and fibroblasts. In addition to these skin cells, elastin fibers are thought to be important for regulating melanocyte functions in normal and abnormal skin. However, the role of elastin has not been fully investigated. Recently, the research on the role of elastin in melanocyte functions has greatly increased even in human skin, whereas no full review article on this subject has been presented so far. Thus, the author tried to present a complete review article on this subject in animals and humans. Methods: The author searched the literature on elastin and melanocytes in research databases. Results: Elastin fibers can affect the normal functions of melanoblasts/melanocytes in animals and humans. Moreover, elastin fibers influence melanocyte functions in abnormal skin. In vitiliginous skin, where melanin and melanoblasts/melanocytes are completely lost, elastin fibers are dramatically reduced. However, elastin fibers are completely restored or even increased in the dermis of repigmented skin after phototherapy and/or skin transplantation. Moreover, elastin fibers penetrate the basement membrane of repigmented skin, suggesting a direct contact between dermal elastin fibers and epidermal melanoblasts/melanocytes. Conclusions: Elastin/elastin fibers may control the functions of mammalian melanocytes in normal and abnormal skin.

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“…Another type of stem cell that resides in the bulge of the HF is the long-lived neural-crest cell-derived melanocyte stem cell, which performs a crucial role in hair pigmentation maintenance [37]. Generally, melanoblasts, the immature progenitors of melanocytes, proliferate and differentiate into melanocytes in the epidermis and migrate to the hair follicle and divided into two categories; the hair matrix melanocytes responsible for pigmenting the original hair and the bulge melanocyte stem cells which are responsible for the following hair cycle pigmentation [38]. The regeneration of the follicular Melanocyte stem cells is synchronized with the HF cycle.…”

Section: The Hair Follicle (Hf) Stem Cellmentioning

confidence: 99%

Keratinocyte Stem Cells: Role in Aging

Ansary¹,

Kamiya²,

Ohtsuki³

2022

Keratinocyte Biology - Structure and Function in the Epidermis

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Stem cells located in the skin are responsible for continual regeneration, wound healing, and differentiation of different cell lineages of the skin. The three main locations of skin stem cells are the epidermis, dermis, and hair follicles. The keratinocyte stem cells are located in the epidermal basal layer (the interfollicular stem cells), hair follicle bulge region (the hair follicle stem cells), and sebaceous glands (the sebaceous gland stem cells) and are responsible for the epidermal proliferation, differentiation, and apoptosis. The interfollicular (IF) stem cells are responsible for epidermis regeneration by proliferating basal cells that attach to the underlying basement membrane and with time they exit from the cell cycle, start terminal differentiation, and move upward to form the spinous, the granular, and the stratum corneum layers. The hair follicle (HF) stem cells are responsible for hair regeneration and these stem cells undergo a cycle consists three stages; growth cycles (anagen), degeneration (catagen), and relative resting phase (telogen). The sebaceous gland (SG) stem cells located in between the hair follicle bulge and the gland and are responsible for producing the entire sebaceous gland which secretes oils to moisture our skin. The role of epidermal stem cells is extremely crucial because they produce enormous numbers of keratinocytes over a lifetime to maintain epidermal homeostasis. However, the age-associated changes in the skin; for example; alopecia, reduced hair density, gray or thin hair, reduced wound healing capacity are related to skin stem cells’ decline functionality with age.

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The human melanocyte and melanoblast populations per unit area of epidermis in the rete ridge are greater than in the inter‐rete ridge

Cited by 7 publications

References 33 publications

Histological assessment of nanostructured fibrin‐agarose skin substitutes grafted in burnt patients. A time‐course study

Histological assessment of nanostructured fibrin‐agarose skin substitutes grafted in burnt patients. A time‐course study

Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin

Keratinocyte Stem Cells: Role in Aging

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