2024
DOI: 10.1093/nar/gkae645
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The human mitochondrial translation factor TACO1 alleviates mitoribosome stalling at polyproline stretches

Michele Brischigliaro,
Annika Krüger,
J Conor Moran
et al.

Abstract: The prokaryotic translation elongation factor P (EF-P) and the eukaryotic/archaeal counterparts eIF5A/aIF5A are proteins that serve a crucial role in mitigating ribosomal stalling during the translation of specific sequences, notably those containing consecutive proline residues (1,2). Although mitochondrial DNA-encoded proteins synthesized by mitochondrial ribosomes also contain polyproline stretches, an EF-P/eIF5A mitochondrial counterpart remains unidentified. Here, we show that the missing factor is TACO1,… Show more

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