The human pancreatic islet cells and their tumors.II. Ulcerogenic and diarrheogenic tumors

Greider, Marie H.; Rosaí, Juan; McGuigan, James E.

doi:10.1002/1097-0142(197405)33:5<1423::aid-cncr2820330529>3.0.co;2-r

Cited by 74 publications

(12 citation statements)

References 61 publications

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“…Although multiple giant gastric ulcers which caused massive bleeding were found, gastrin production was ruled out immunohistologically (5). However, endocrine tumors of the pancreas may be ulcerogenic, and the possibility that the giant ulcers may have been caused by some unknown hormones produced by this neuroendocrine tumor cannot be ruled out completely (18,19). Genetic abnormalities which cause von Hippel-Lindau disease have becomeclear.…”

Section: Discussionmentioning

confidence: 99%

Somatostatinoma of the Pancreas Associated with von Hippel-Lindau Disease.

et al. 1995

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A 39-year-old manwas admitted because of lumbago, vomiting and massive gastrointestinal bleeding. Oliguria developed a few days later, which was followed by hyperkalemia and cardiac arrest. Autopsy disclosed multiple renal cell carcinomas with diffuse metastasis to the liver, adrenal gland, psoas muscle and vertebrae. In addition, a somatostatinoma wasfound in the pancreas. From these findings and past history of cerebellar hemangioblastoma and spinal hemangioma he was diagnosed to have von Hippel-Lindau disease. Von Hippel-Lindau disease with islet cell tumor is very rare and is reported here with a review of literature. (Internal Medicine 34: 661-665, 1995)

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Section: Discussionmentioning

confidence: 99%

Somatostatinoma of the Pancreas Associated with von Hippel-Lindau Disease.

et al. 1995

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“…Most cells stain with argyrophilic dyes or with antisera directed against pancreatic glucagon (4-6, 10, 20, 51, 67, 73, 76, 84, 94, 95). Secretory granules are usually found in at least some cells of a given neoplasm, appearing uniformly either as mature forms or as granules of varying electron density ranging between 100-400 nm in diameter (13,15,20,23,51,73,76,88,95,106). They may show an eccentrically placed core and contain a halo (51,73,106), or they may be homogenous (13,73,76,106).…”

Section: Summer 1981mentioning

confidence: 99%

The Glucagonoma Syndrome: Clinical Features, Diagnosis, and Treatment

1981

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Historical BackgroundIslet cell tumors of the pancreas have been described for over 50 yr. Although carcinoma arising from islet tissue had been noted since the turn of the century (1), not until 1927 was the first case of a hormonally active pancreatic neoplasm, an insulinoma, recorded (2). For many years thereafter, pancreatic endocrine tumors were characterized as either insulin-producing or "nonfunctional," the latter being derived from cells apparently devoid of clinically significant hormonal activity. With time, however, other islet cell secretory products were discovered and their tumors identified with various clinical syndromes. Whereas the hypoglycemia of insulinomas and hyperacidity of gastrinomas figured prominently in the initial recognition of these neoplasms, the clinical signs of glucagon-producing tumors were less readily apparent and not as easily attributable to specific hormone excess.Becker and co-workers (3) are credited with the first description of a glucagonoma. Their case, reported in 1947 but diagnosable only in retrospect, typifies what is now regarded as a classic clinical presentation of the syndrome. The patient, a 45-yr-old woman, sought attention because of a skin rash that, over a period of 8 months, progressed to involve almost her entire body. Weight loss, weakness, and amenorrhea were additional complaints. The rash was symmetrically distributed and characterized by confluent, pruritic areas of macular, erythematous, and vesicular erruptions showing evidence of exfoliation and superficial necrosis. Stomatitis and onchonolysis were also found. Laboratory examination revealed a normochromic anemia, mild fasting hyperglycemia, and hypoproteinemia. Deep venous thrombosis developed while the patient was in hospital, and she succumbed to cardiorespiratory failure. At autopsy, an islet cell neoplasm was discovered "replacing the body

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“…These APUD or neuroendocrine cells scattered throughout the foregut are seen in gastric, duodenal, and bronchial carcinoid tumors. 20,21 Although there are many reports of melanin pigment identified in carcinoid tumors of the lung and thymus, among others, there have not been well-documented reports of pancreatic carcinoid tumors in which melanin has been identified absolutely. Pearse and Takor 19 concluded that the carcinoid tumor does not arise from the enterochro- maffin cell but from a multipotential precursor.…”

Section: Discussionmentioning

confidence: 99%