The Human PECAM1 Gene Maps to 17q23

Rj, Gumina; Ne, Kirschbaum; Pn, Rao; vanTuinen, Peter; Newman, PJ

doi:10.1006/geno.1996.0272

Cited by 58 publications

(34 citation statements)

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“…PECAM-1 is encoded by a 75-kb gene that resides at the end of the long arm of chromosome 17 (7). The earliest reports of PECAM-1 in the literature described it variously as a myeloid differentiation antigen (8,9) or as a homologue of platelet GPIIa (the integrin ␤ 1 subunit) present within the plasma membrane of endothelial cells (1).…”

Section: Structure Of the Pecam-1 Gene And Proteinmentioning

confidence: 99%

The biology of PECAM-1.

Newman¹

1997

J. Clin. Invest.

580

435

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IntroductionPlatelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and selected T cell subsets. It is also a major constituent of the endothelial cell intercellular junction (1-3), where up to 10 6 PECAM-1 molecules (4) are concentrated. With a few minor exceptions, PECAM-1 is not present on fibroblasts, epithelium, muscle, or other nonvascular cells. Since its cloning nearly 10 yr ago (5, 6), much has been learned about the structure of this cell adhesion receptor and its function in vascular cells. The purpose of this brief Perspective is to review progress in the field of PECAM-1 biology, and to bring the reader up to date on current concepts about ( a ) the function of PECAM-1 in the different vascular cells in which it is expressed; ( b ) the molecular mechanisms by which PECAM-1 mediates cell-cell interactions; and ( c ) its role in bidirectional transmembrane signal transduction. In keeping with the intent of this series to discuss issues of cell adhesion in the context of human biology and pathophysiology, the potential clinical relevance of PECAM-1-mediated cellular interactions to thrombotic, inflammatory, and immunological diseases will be underscored at relevant points throughout the review.

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Section: Structure Of the Pecam-1 Gene And Proteinmentioning

confidence: 99%

The biology of PECAM-1.

Newman¹

1997

J. Clin. Invest.

580

435

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“…Interestingly, the human PECAM-1 gene maps to chromosome 17q23. 42 Further studies will be required to define the role of PECAM-1 gene in the emergence of autoimmunity.…”

Section: Pecam-1 Regulates B-cell Responsiveness 191mentioning

confidence: 99%

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)–mediated activation, and autoimmune disease

Wilkinson

Lyons

Roberts

et al. 2002

Blood

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“…It also interacts in a heterophilic way with ligands such as ␣ v ␤ 3 , CD38, and Plasmodium falciparum-infected erythrocytes (7, 10 -13). PECAM-1 is encoded by a 65-kb gene allocated in the long arm of chromosome 17 (14,15), and the region driving its transcription has been identified as a TATA-less promoter containing relevant EGR-1 and GATA-2 cisregulatory elements (16,17). In addition, two consensus sites for NF-B were identified at Ϫ409 (GGGGTTCTCC) and at ϩ110 (GAGGAATCCCC) (16), although their functional relevance is not known.…”

Section: Identification Of a Functional Nf-b Site In The Plateletmentioning

confidence: 99%

Identification of a Functional NF-κB Site in the Platelet Endothelial Cell Adhesion Molecule-1 Promoter

Botella

Puig‐Kröger

Almendro

et al. 2000

The Journal of Immunology

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Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a type I transmembrane adhesion protein of 130 kDa that belongs to a subgroup of the Ig gene superfamily, characterized by the presence of immunoreceptor tyrosine-based inhibitory motifs. PECAM-1 is expressed in circulating platelets, monocytes, neutrophils, a selective subgroup of T cells, and in endothelial cells, where it is preferentially located at intercellular junctions and participates in leukocyte transmigratory processes. The identification of two consensus NF-κB sites within the PECAM-1 promoter led us to analyze their possible involvement in the PECAM-1 expression regulated by inflammatory stimuli. We found that surface expression and promoter activity of PECAM-1 in myeloid cells are regulated by modulators of NF-κB, including TNF-α, PMA, and pyrrolidine dithiocarbamate. Mobility shifts assays identified a specific NF-κB-binding element at +110/+120, whose mutation abolished the basal promoter activity of PECAM-1 and decreased NF-κB-dependent responses of the PECAM-1 gene promoter. Furthermore, cotransfection experiments with an expression vector encoding the p65 subunit of NF-κB showed transactivation of the PECAM-1 promoter. These results demonstrate that NF-κB can regulate the transcriptional activity of PECAM-1.

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The Human PECAM1 Gene Maps to 17q23

Cited by 58 publications

References 0 publications

The biology of PECAM-1.

The biology of PECAM-1.

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)–mediated activation, and autoimmune disease

Identification of a Functional NF-κB Site in the Platelet Endothelial Cell Adhesion Molecule-1 Promoter

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