The human periodontal membrane – focusing on the spatial interrelation between the epithelial layer of Malassez, fibers, and innervation

Kjær, Inger; Nolting, Dorrit

doi:10.1080/00016350802714726

Cited by 21 publications

(5 citation statements)

References 26 publications

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“…These observations indicate that innervation is not only important for early tooth formation (6, 7) but also for eruption. As innervation has recently been observed in the close proximity of the root surface (10), it is suggested that the innervation plays a role not only in the onset of tooth formation and for the eruption process but also for the ongoing root formation or maturation.…”

Section: Discussionmentioning

confidence: 99%

Delayed dental maturity in dentitions with agenesis of mandibular second premolars

Daugaard

Christensen

Kjær

2010

Orthodontics &Amp; Craniofacial Research

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In unilateral agenesis, the canines are specifically delayed in both girls and boys, with a larger delay in girls (p=0.009). The second molar is not delayed in boys (p=0.98) but is in girls (p=0.04). The differences in delay for the canine compared to the second molar are significant for both girls and boys. The results show a considerable delay in tooth maturation within the canine/premolar innervation field predominantly in girls. The 2nd molar is delayed in girls but not in boys.

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Section: Discussionmentioning

confidence: 99%

Delayed dental maturity in dentitions with agenesis of mandibular second premolars

Daugaard

Christensen

Kjær

2010

Orthodontics &Amp; Craniofacial Research

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“…39 A close association between ERM and nerve fibers in the PDL space has been demonstrated in several species. 35 -38,40 -42 It has been shown that experimental transection of the inferior alveolar nerve in rats not only reduced the distribution and size of ERM cell clusters but also resulted in dentoalveolar ankylosis. 43…”

Section: Morphologymentioning

confidence: 99%

A Review of the Epithelial Cell Rests of Malassez on the Bicentennial of Their Description

Davis¹

2018

J Vet Dent

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The epithelial cell rests of Malassez (ERM) were first described in 1817, yet their significance has remained an enigma for more than 200 years. Given their embryological origins and persistence in adult periodontal tissue, recent research has investigated whether the ERM could be useful as stem cells to regenerate tissues lost as a consequence of periodontitis. The objective of this review is to describe results of studies that have vigorously investigated the functional capabilities of ERM, particularly with regard to periodontal ligament homeostasis and prevention of dentoalveolar ankylosis. The significance of the ERM relative to evolution of the dental attachment apparatus will be examined. The current status of use of ERM as stem cells for dental tissue engineering and in other applications will be reviewed.

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“…D marks the dentin. Left: normally developed root surface (brown nerve cells) [89, 103]. Right: two sections of tooth root surfaces from teeth extracted due to arrested eruption.…”

Section: Figurementioning

confidence: 99%

Mechanism of Human Tooth Eruption: Review Article Including a New Theory for Future Studies on the Eruption Process

Kjær

2014

Scientifica

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Human eruption is a unique developmental process in the organism. The aetiology or the mechanism behind eruption has never been fully understood and the scientific literature in the field is extremely sparse. Human and animal tissues provide different possibilities for eruption analyses, briefly discussed in the introduction. Human studies, mainly clinical and radiological, have focused on normal eruption and gender differences. Why a tooth begins eruption and what enables it to move eruptively and later to end these eruptive movements is not known. Pathological eruption courses contribute to insight into the aetiology behind eruption. A new theory on the eruption mechanism is presented. Accordingly, the mechanism of eruption depends on the correlation between space in the eruption course, created by the crown follicle, eruption pressure triggered by innervation in the apical root membrane, and the ability of the periodontal ligament to adapt to eruptive movements. Animal studies and studies on normal and pathological eruption in humans can support and explain different aspects in the new theory. The eruption mechanism still needs elucidation and the paper recommends that future research on eruption keeps this new theory in mind. Understanding the aetiology of the eruption process is necessary for treating deviant eruption courses.

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The human periodontal membrane – focusing on the spatial interrelation between the epithelial layer of Malassez, fibers, and innervation

Abstract: It is suggested that the genetic composition of the epithelial layer of Malassez in the periodontal membrane may be the key to understanding the different functions of the periodontal membrane and also the individual differences of these functions.

Cited by 21 publications

References 26 publications

Delayed dental maturity in dentitions with agenesis of mandibular second premolars

Delayed dental maturity in dentitions with agenesis of mandibular second premolars

A Review of the Epithelial Cell Rests of Malassez on the Bicentennial of Their Description

Mechanism of Human Tooth Eruption: Review Article Including a New Theory for Future Studies on the Eruption Process

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