The human platelet fibrinogen receptor: clinical and therapeutic significance.

Cahill, M; Mistry, Rajendra; Barnett, D B

doi:10.1111/j.1365-2125.1992.tb03993.x

Cited by 22 publications

(10 citation statements)

References 48 publications

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“…The methodology was subjected to rigorous analysis before clinical studies commenced. Alterations of assay parameters such as time to analysis, washing, fixation and antibody and control concentration were repeatedly examined ( Cahill, 1995) before this study. The coefficient for inter‐assay variation in the measurement of P‐selectin and GP53 expression was between 10% and 15%.…”

Section: Methodsmentioning

confidence: 99%

Protein A immunoadsorption in chronic refractory ITP reverses increased platelet activation but fails to achieve sustained clinical benefit

et al. 1998

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Adults with chronic relapsing ITP present a difficult therapeutic challenge. The ongoing antibody-mediated platelet destruction in this group might be expected to be associated with increased expression of platelet surface membrane activation antigens. We have studied a group of 10 patients with refractory ITP and 35 healthy controls. Using an immediate, sensitive, unfixed, whole blood, flow cytometric method to detect platelet surface P-selectin and GP53, we have detected markedly increased platelet activation in the ITP group compared with the controls (P-selectin; patient median 24.5% v control median 2.0%. GP53 median 6.5% v 2.1%, P < 0.01 for both). Five patients underwent protein A immunoadsorption therapy. The effect of protein A immunoadsorption on platelet activation before, during and after 18 treatments in these patients was studied and patients were followed-up to assess clinical outcome. Platelet-associated immunoglobulin measurements were made before and at the end of six treatments. Platelet activation decreased after immunoadsorption. P-selectin expression fell significantly; pre- and post-treatment median values differed by 15.5%, P < 0.01, for GP53 the difference was 2.5%, P = NS. A reduction in both platelet-associated IgG (median reduction of 11.8 ng/10(6) platelets, P = 0.08) and IgM (7.6 ng/10(6) platelets, P = 0.06) was recorded.

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Section: Methodsmentioning

confidence: 99%

Protein A immunoadsorption in chronic refractory ITP reverses increased platelet activation but fails to achieve sustained clinical benefit

et al. 1998

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“…Fibrinogen is a large hexameric plasma glycoprotein, which plays a vital role in a number of pathophysiologic processes, including inflammation, atherogenesis, and thrombogenesis (36). Plasma fibrinogen may influence kidney function through its effect on the coagulation cascade, blood viscosity, and blood flow in the microcirculation (37). Fibrinogen is a receptor-mediated mitogen for renal fibroblasts and a possible facilitator of tubulointerstitial fibrosis (38).…”

Section: Discussionmentioning

confidence: 99%

Inflammation and Progression of CKD: The CRIC Study

Amdur¹,

Feldman²,

Gupta³

et al. 2016

CJASN

342

256

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Background and objectives CKD is a global public health problem with significant mortality and morbidity.Design, setting, participants, & measurements We examined the multivariable association of plasma levels of IL-1, IL-1 receptor antagonist, IL-6, TNF-a, TGF-b, high-sensitivity C-reactive protein, fibrinogen, and serum albumin with progression of CKD in 3430 Chronic Renal Insufficiency Cohort study participants.Results Over a median follow-up time of 6.3 years, 899 participants reached the composite end point of $50% decline in eGFR from baseline or onset of ESRD. Elevated plasma levels of fibrinogen, IL-6, and TNF-a and lower serum albumin were associated with a greater decline in eGFR over time. After adjusting for demographics, BP, laboratory variables, medication use, and baseline eGFR, hazard ratios for the composite outcome were greater for the patients in the highest quartile of fibrinogen (hazard ratio, 2.05; 95% confidence interval, 1.64 to 2.55; P,0.001), IL-6 (hazard ratio, 1.44; 95% confidence interval, 1.17 to 1.77; P,0.01), and TNF-a (hazard ratio, 1.94; 95% confidence interval, 1.52 to 2.47; P,0.001) compared with those in the respective lowest quartiles. The hazard ratio was 3.48 (95% confidence interval, 2.88 to 4.21; P,0.001) for patients in the lowest serum albumin quartile relative to those in the highest quartile. When also adjusted for albuminuria, the associations of fibrinogen (hazard ratio, 1.49; 95% confidence interval, 1.20 to 1.86; P,0.001), serum albumin (hazard ratio, 1.52; 95% confidence interval, 1.24 to 1.87; P,0.001), and TNF-a (hazard ratio, 1.42; 95% confidence interval, 1.11 to 1.81; P,0.001) with outcome were attenuated but remained significant.Conclusions Elevated plasma levels of fibrinogen and TNF-a and decreased serum albumin are associated with rapid loss of kidney function in patients with CKD.

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“…34,35 Fibrinogen is also involved in the final common pathways of the coagulation and platelet aggregation. 36 The enzymatic cleavage of fibrinogen into fibrin monomers by thrombin and their subsequent linkage to fibrin polymers is a critical step in thrombus formation.…”

Section: Discussionmentioning

confidence: 99%

Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population

Stack

Donigiewicz

Abdalla

et al. 2014

QJM

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SummaryBackground: The contribution of novel risk factors to mortality in chronic kidney disease remains controversial. Aim: To explore the association of plasma fibrinogen with mortality among individuals with normal and reduced kidney function. Methods: We identified 9184 subjects, age 40 and over from the Third National Health and Nutrition Examination Survey (1988-94) with vital status assessed through 2006. Plasma fibrinogen was modeled as continuous variable and in quartile groups (0 to <7.7, 7.7 to <9.0, 9.0 to <10.5 and 510.5 mmol/l) with total and cardiovascular mortality across categories of glomerular filtration rate (eGFR); <60, 60-90, >90 ml/min/1.73 m 2 using Cox regression. Results: In multivariate analysis, the adjusted hazard ratio (HR) per 1 mmol/l (34 mg/dl) increase in fibrinogen was 1.07 [95% confidence interval (CI)

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The human platelet fibrinogen receptor: clinical and therapeutic significance.

Cited by 22 publications

References 48 publications

Protein A immunoadsorption in chronic refractory ITP reverses increased platelet activation but fails to achieve sustained clinical benefit

Protein A immunoadsorption in chronic refractory ITP reverses increased platelet activation but fails to achieve sustained clinical benefit

Inflammation and Progression of CKD: The CRIC Study

Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population

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