The Human Prefrontal and Parietal Association Cortices Are Involved in NO-GO Performances: An Event-Related fMRI Study

Watanabe, Jobu; Sugiura, Motoaki; Sato, Kazunori; Sato, Yuko; Maeda, Yasuhiro; Matsue, Yoshihiko; Fukuda, Hiroshi; Kawashima, Ryuta

doi:10.1006/nimg.2002.1198

Cited by 266 publications

(159 citation statements)

References 38 publications

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“…Despite a decline in performance, participants were able to successfully inhibit a prepotent response on the majority of No-go trials, and during these inhibitions activation was seen in prefrontal, parietal (predominantly right hemisphere), midline (ACC and pre-SMA), and subcortical regions, consistent with the findings of previous Go/No-go tasks (de Zubicaray et al, 2000;Garavan et al, 2002;Konishi et al, 1999;Liddle et al, 2001;Rubia et al, 2003;Watanabe et al, 2002). Given this performance, we examined further how this network of regions successfully responded to increasing WM demand.…”

Section: Interactions Between Working Memory and Inhibitionsupporting

confidence: 65%

“…Successfully withholding a response to the No-go trials is argued to represent inhibitory control over a prepotent response, typically resulting in activation of prefrontal, parietal (predominantly right hemisphere), and midline (ACC and pre-SMA) regions (de Zubicaray et al, 2000;Garavan et al, 2002;Konishi et al, 1999;Liddle et al, 2001;Rubia et al, 2003;Watanabe et al, 2002). In line with previous behavioral studies, we predicted that increasing WM load would negatively influence inhibitory performance; however, it was unclear from previous literature what influence WM load would have on this event-related inhibitory activation response.…”

Section: Introductionsupporting

confidence: 63%

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Beyond common resources: the cortical basis for resolving task interference

2004

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Recent studies have suggested that declining inhibitory control observed during simultaneous increases in working memory (WM) demands may be due to sharing common neural resources, although it is relatively unclear how these processes are successfully combined at a neural level. Event-related functional MRI was used to examine task performance that required inhibition of varying numbers of items held in WM. Common activation regions for WM and inhibition were observed and this functional overlap may constitute the cortical basis for task interference. However, maintaining successful inhibitory control under increasing WM demands tended not to increase activation in these overlapping regions as might be expected if these common areas reflect common resources essential for task performance. Instead, increased activation was observed predominantly in unique, inhibition-specific regions including dorsolateral prefrontal cortex. The finding that successfully maintaining weaker stimulus -response relationships in the face of competition from stronger, prepotent responses requires greater activity in these regions reveals the means by which the brain resolves task interference and supports theories of how top-down attentional control is implemented. D

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Section: Interactions Between Working Memory and Inhibitionsupporting

confidence: 65%

Section: Introductionsupporting

confidence: 63%

Beyond common resources: the cortical basis for resolving task interference

2004

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“…Here, inhibition was identified bilaterally within the inferior frontal gyrus including the dorsolateral pre-frontal cortex, an area associated with response inhibition (Aron et al, 2003;Liddle et al, 2001;Watanabe et al, 2002), and also bilaterally within nuclei of the basal ganglia, specifically the putamen and the substantia nigra, that are not typically associated with response inhibition (Aron and Poldrack, 2006). It is suggested that the subthalamic nucleus (a subcortical region in the basal ganglia) may play a role in inhibiting initiated responses by suppressing basal ganglia-thalamocortical output via an inhibitory pathway from the inferior frontal cortex (Aron and Poldrack, 2006).…”

Section: Discussionmentioning

confidence: 97%

“…Associated with breath holding, we identified activity within the insula, basal ganglia, frontal cortex, parietal cortex, thalamus and temporal cortex, areas that are commonly reported in imaging studies of response inhibition using Go/NoGo and Stop-signal paradigms (Aron et al, 2003;Liddle et al, 2001;Watanabe et al, 2002). In Go/NoGo paradigms the subject is required to inhibit a prepotent response, whereas in the Stop-signal paradigms the subject inhibits an action that has already been initiated.…”

Section: Discussionmentioning

confidence: 99%

“…Previous respiratory related imaging studies have highlighted specific loci within the sensorimotor cortices and the subcortex, specifically the thalamus and basal ganglia ( (Evans et al, 1999;McKay et al, 2000), that underlie volitional respiratory control; however, these studies have investigated active respiratory control rather than inhibition. Direct parallels of breath holding do not exist in other human behaviours but imaging studies of response inhibition during Go/NoGo and Stop-signal tasks (Aron and Poldrack, 2006;Liddle et al, 2001;Watanabe et al, 2002) and those related to inhibiting saccadic eye reflexes (Jueptner et al, 1996), highlight the dorsolateral prefrontal cortex, basal ganglia and thalamus as having a role in inhibiting behaviours. Within the brainstem, animal models have shown that stimulation of pontine respiratory neurones can lead to apnoea, hypernoea or apneusis (Chamberlin, 2004;Fung and St John, 1994;Mutolo et al, 1998), while ablation of the preBötzinger complex (preBötC), a small region of the ventrolateral medulla, can lead to central sleep apnoea and ataxic breathing during wakefulness (Gray et al, 2001;McKay et al, 2005) We hypothesised that breath holding would be associated with an inhibitory network of subcortical structures including the pons.…”

Section: Introductionmentioning

confidence: 99%

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A bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging

et al. 2008

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ABSRACTFew tasks are simpler to perform than a breath hold; however, the neural basis underlying this voluntary inhibitory behaviour, which must suppress spontaneous respiratory motor output, is unknown. Here, using blood oxygen level dependant functional magnetic resonance imaging (BOLD fMRI), we investigated the neural network responsible for volitional breath holding in 8 healthy humans. BOLD images of the whole brain (156 brain volumes, voxel resolution 3x3x3mm) were acquired every 5.2s. All breath holds were performed for 15 seconds at resting expiratory lung volume when respiratory musculature was presumed to be relaxed, which ensured that the protocol highlighted the inhibitory components underlying the breath hold. An experimental paradigm was designed to dissociate the time course of the whole-brain BOLD signal from the time course of the local, neural-related BOLD signal associated with the inhibitory task. We identified a bilateral network of cortical and subcortical structures including the insula, basal ganglia, frontal cortex, parietal cortex and thalamus, that are in common with response inhibition tasks, and in addition, activity within the pons. From these results we speculate that the pons has a role in integrating information from supra-brainstem structures, and in turn it exerts an inhibitory effect on medullary respiratory neurones to inhibit breathing during breath holding.2

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