The human respiratory nasal mucosa in females using contraceptive pills

Toppozada, Hussein H.; Toppozada, M.; El-Ghazzawi, I.; Elwany, Samy

doi:10.1017/s002221510014616x

Cited by 75 publications

(55 citation statements)

References 12 publications

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“…9 Steroid hormonlarındaki değişiklikler ile nazal mukozadaki histokimyasal ve ultramikroskobik değişik-likler menstrüel siklus sırasında, gebelikte, oral kontraseptif kullanımında ve menopoz sonrasında araştırılmıştır. [10][11][12] Dişi hormonlarının hangi mekanizma ile nazal fizyolojiyi etkilediği net olmamakla birlikte, progesteron ve östrojen alfa reseptörleri nazal mukozada saptanmamıştır. Ancak, östrojen beta reseptörleri hem erkek hem de dişilerin nazal mukozasında bulunmaktadır.…”

Section: Discussionunclassified

Mucociliary Clearance Time During Menstrual Cycle in Healthy Women

Karapınar¹,

Özler²,

Demirel³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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ukosiliyer aktivite, nazal solunum epitelinin en önemli savunma mekanizmasıdır. Zararlı olabilecek maddeler bu mukus örtü içinde tutulmakta ve siliyaların metakronik hareketleri ile nazal kaviteden uzaklaştırılmaktadır.1 Çevresel, metabolik ve farmakolojik birçok faktör mukosiliyer aktiviteyi etkilemektedir.2 Steroid hormon değişimle-rinin de nazal mukoza aktivitesini etkilediği bildirilmiştir. [3][4][5][6] Turkiye Klinikleri J Gynecol Obst 2016;26(4) 205Sağlıklı Kadınlarda Menstrüel Siklus Esnasında Mukosiliyer Klerens Süresi Ö ÖZ ZE ET T A Am ma aç ç: : Nazal mukosiliyer klerens, nazal solunum epitelinin en önemli savunma mekanizmasıdır. Hormonal değişikliklerin nazal mukoza aktivitesini etkilediği varsayılmaktadır. Bu çalış-mada sağlıklı kadınlarda menstrüel siklusun mukosiliyer klerens süresi üzerine etkisi araştırılmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma grubunu, yaşları 20-40 yıl arasında 25 sağlıklı kadın oluşturdu. Katılımcılar ayrıntılı anamnez, kulak-burun-boğaz muayenesi ve nazal endoskopi sonrasında nazal mukosiliyer klerens süresi, midsiklus ve menstrüasyon esnasında sakarin testi ile değerlendirildi. B Bu ul lg gu ul la ar r: : Çalışmaya katılan kadınların yaş ortalaması (±standart sapma) 34,7±4,6 yıl idi. Midsiklusta mukosiliyer klerens süresi ortalama 11,7±2,8 (aralık:7-16 dk) iken, menstrüasyon esnasında bu değer istatistiksel olarak daha uzun, 16,3±2,4 (aralık:12-22 dk) olarak saptandı (p=0,0001). S So on nu uç ç: : Bu ça-lışmada, kadınların menstrüasyon esnasında nazal mukosiliyer klerens süresinin uzadığı saptanmıştır. Menstrüasyon esnasında hastaların sıklıkla şikâyetçi olduğu nazal tıkanıklık hissi nazal mukosiliyer klerens süresinin uzamasına bağlı olabilir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Menstrüel siklus; ovülasyon; menstruasyon; nazal mukoza

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Section: Discussionunclassified

Mucociliary Clearance Time During Menstrual Cycle in Healthy Women

Karapınar¹,

Özler²,

Demirel³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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“…The relationship between the hormone estrogen and the nasal mucosa has been postulated by clinical studies that advocate the existence of an entity named hormonal rhinitis, or nasal diseases caused by variations in the hormone levels, especially estrogen, and according to the work of Philpott et al (2004Philpott et al ( , 2008, Shirasaki et al (2004); Toppozada et al (1981Toppozada et al ( , 1982Toppozada et al ( , 1984Toppozada et al ( , 1988 and Zhao et al (2001).…”

Section: Discussionmentioning

confidence: 99%

“…Estrogen receptors (ER) are detectable in the human body tissues, including tissues of reproductive organs, nasal mucosa and nervous system (Ciocca & Roig, 1995;Bowser & Riederer, 2001;Berger et al, 2003;Kuiper et al, 1997;Millas et al, 2011;Philpott et al, 2004Philpott et al, , 2008Shirasaki et al, 2004;Toppozada et al, 1981Toppozada et al, , 1982Toppozada et al, , 1984Toppozada et al, , 1988. To evaluate staining intensity, different methods have been designed as RT-PCR and immunohistochemistry (Bowser & Riederer;Pavao & Traish;Shirasaki et al;Zhao et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Estrogen Receptors in Immunohistochemically Stained Slides: Comparing Subjective and Computerized Evaluation Methods

et al. 2014

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SUMMARY:Immunohistochemistry is a specific and sensitive staining method for detection of several proteins. One important function of this method is to help us on the diagnosis of the presence of specific receptors as the estrogen receptors. The aim of this study was to compare two different methods to evaluate immunohistochemical staining intensity to detect the presence of ER in the nasal mucosa tissue: one using a digital system and the other through conventional direct microscopy observation. Sixty two stained samples were observed and analyzed under optic microscopy by three specialized professionals, who have graded intensity from: absent, mild, moderate and intense staining. Afterwards, an objective measurement was obtained by a relative optical density (ROD) reading, through the MCID 7.0 system of densitometric digital analysis (Inter Focus Imaging LTDA, Linton, England). Subjective and objective classifications were compared under statistical analysis (Kolmogorov-Smirnov and Spearman Correlation Test, p<0.05). We found a positive correlation between the subjective findings of observers and digital analysis in all the categories of beta receptor. For the alpha receptor, there was a correlation only in extreme categories. The subjective evaluations by observers and digital method by measuring the relative optical density show statistically significant correlations in quantifying the estrogen receptors by immunohistochemistry staining. This indicates that both methods show accuracy for the proposed study.

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Section: Introductionmentioning

confidence: 99%

“…These abnormalities consist of epithelial metaplasia, lymphocyte infiltration, increased vascularity and glandular hyperactivity (Toppozada et al, 1984). Toppozada et al (1981;1984) contributed through studies on humans that demonstrated morphological and histochemical changes to the nasal mucosa that were associated with estrogen. In a experimental study on guinea pigs, Zhao et al (1994), noted histological abnormalities such as thickening of epithelial layers, edema of the corium, hyperplasia of glands and increased density of cilia in the mucosa of guinea pigs receiving estrogen compared with the control group.…”

Section: Introductionmentioning

confidence: 99%

Inmunohistochemical Evaluation of Estrogen Receptors Alpha and Beta in Normal Inferior Turbinate Mucosa

Millas¹,

Liquidato²,

Dolci³

et al. 2010

Int. J. Morphol.

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SUMMARY:It has been postulated that the nasal mucosa, like other human tissues, is affected by a complex interactive network of neuropeptides, cytokines, allergic and inflammatory mediators and hormones such as estrogen, in which associations between symptoms (e.g. nasal stuffiness and coryza) and hormonal variations deriving from pregnancy, use of hormonal contraceptives and menstrual cycle phases are observed. The objective is evaluating the presence of specific estrogen receptors (types alpha and beta) in inferior turbinate mucosa in healthy subjects without nasal symptoms. Samples of nasal inferior turbinate were removed from patients undergoing aesthetic nasal surgery, and analyzed using hematoxylin-eosin staining, followed by immunohistochemical preparations on paraffin-embedded sections from the material sample, to detect estrogen receptors alpha and beta. Positive immunohistochemical reactions for both beta

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The human respiratory nasal mucosa in females using contraceptive pills

Cited by 75 publications

References 12 publications

Mucociliary Clearance Time During Menstrual Cycle in Healthy Women

Mucociliary Clearance Time During Menstrual Cycle in Healthy Women

Estrogen Receptors in Immunohistochemically Stained Slides: Comparing Subjective and Computerized Evaluation Methods

Inmunohistochemical Evaluation of Estrogen Receptors Alpha and Beta in Normal Inferior Turbinate Mucosa

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