The Human Toxicology of Dimethyl Sulfoxide

Brobyn, Richard

doi:10.1111/j.1749-6632.1975.tb25394.x

Cited by 90 publications

(38 citation statements)

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“…38 Even prolonged exposure to large topical doses of DMSO (1 g/kg daily for up to 3 months) rarely produced enzyme elevations. 39 For comparison, in this study a 60-kg person who applied diclofenac solution to both knees received only 0.06 g/kg of DMSO daily.…”

Section: Discussionmentioning

confidence: 99%

Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial

Bookman¹,

Williams²,

Shainhouse³

2004

Canadian Medical Association Journal

152

143

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Section: Discussionmentioning

confidence: 99%

Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial

Bookman¹,

Williams²,

Shainhouse³

2004

Canadian Medical Association Journal

152

143

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“…(Hsu, McNamara & Segal, 1977). However, DMSO is far from inert; it may, for example, cause changes in membrane permeability (Brobyn, 1975). The lack of change in renin release in response to the addition of 0-5 % DMSO is in accordance with the prediction that volume changes should be minimal or absent due to the high permeability of cell membranes to DMSO.…”

Section: Discussionmentioning

confidence: 49%

Renin release from isolated rat glomeruli: effects of colchicine, vinca alkaloids, dimethylsulphoxide, and cytochalasins.

Baumbach¹

1980

The Journal of Physiology

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SUMMARY1. Preparations of isolated glomeruli were superfused and the effects of colchicine, the vinca alkaloids, and the cytochalasins A, B, D, and E investigated on basal renin release and the response of the glomeruli to osmotic stress.2. Colchicine (10-3 M) had no effect, whereas vinblastine and vincristine (10-5 M) caused a progressive increase in basal renin release from isolated glomeruli.3. After 60 min exposure to either colchicine or the vinca alkaloids, the first renin release response to a hypoosmotic challenge (reduction in sucrose or sodium chloride concentration) was depressed while that of the second (after 120 min exposure) was enhanced. 6. The normal response to the first 30 m-osmole/kg reduction in NaCl concentration (and medium osmolality) was abolished by 0-5 % DMSO. Rather, a depressed release compared to unstimulated control experiments was observed. The response to the second stimulus in the presence of DMSO was about half that of control experiments. 7. Following the first hypoosmotic stimulus (by lowering the concentrations of sucrose or NaCl) the cytochalasins A, B, D and E (5 jug/ml.) caused an increased release of renin which persisted throughout the length of the experiment. The cytochalasins used were equally potent in this respect.8. The results are in agreement with previous findings, suggesting that renin release from the juxtaglomerular cells adhering to isolated glomeruli is mediated through a mechanism different from exocytosis.

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“…This amount corresponds to about half the LOAEL (lowest observed adverse effect level) established in the study of Brobyn (1975). A NOAEL was not established in this study.…”

Section: Manifesto (Absorption Through the Skin)mentioning

confidence: 97%

“…However, when the fluxes determined for toluene, N-methyl-2-pyrrolidone and N,N-dimethylformamide in the study of Ursin et al (1995) were compared with those given in the literature (Ahaghotu et al 2005;Bader et al 2005;Kezic et al 2001;Larese et al 1994) the level of agreement of the values was acceptable. Dermal application of an 80% DMSO gel in a dose of 1000 mg/kg body weight and day induced central nervous symptoms in humans, transient eosinophilia and in some cases severe local skin reactions caused by the release of histamine (Brobyn 1975). A NOAEL (no observed adverse effect level) for humans is not known.…”

Section: Absorption Through the Skinmentioning

confidence: 99%

Dimethyl sulfoxide (DMSO) [MAK Value Documentation, 2011]

Hartwig

2017

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the designation with “H” (for substances for which skin contact is expected to contribute significantly to the systemic toxicity) for DMSO [67‐68‐5]. Based on a diffusion cell study with excised human skin, 35.2 g DMSO (about 500 mg/kg body weight) would be dermally absorbed each hour through an area of 2000 cm 2 of skin. This amount corresponds to about half of the LOAEL (lowest observed adverse effect level) established in volunteers. Therefore, skin contact is expected to contribute significantly to the systemic toxicity of DMSO, and DMSO is still designated with an “H”.

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The Human Toxicology of Dimethyl Sulfoxide

Cited by 90 publications

References 0 publications

Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial

Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial

Renin release from isolated rat glomeruli: effects of colchicine, vinca alkaloids, dimethylsulphoxide, and cytochalasins.

Dimethyl sulfoxide (DMSO) [MAK Value Documentation, 2011]

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