The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis

Lopez, Christophe; Blanke, Olaf; Mast, Fred W.

doi:10.1016/j.neuroscience.2012.03.028

Cited by 386 publications

(425 citation statements)

References 129 publications

(215 reference statements)

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“…These preliminary results showed significant activation over the major areas involved with multimodal functions of the vestibular system (Bense et al, 2001) and are in agreement with previous galvanic vestibular stimulation studies with fMRI (Eickhoff et al, 2006a;Fink et al, 2003;Smith et al, 2012;Stephan et al, 2005). Also, the results showed here corroborate with a meta-analysis study that evaluate the statistical analysis of the localization of the human vestibular cortex in neuroimaging studies using caloric vestibular stimulation, galvanic vestibular stimulation and auditory stimulus (Lopez et al, 2012).…”

Section: Discussionsupporting

confidence: 91%

Galvanic vestibular stimulator for fMRI studies

Della-Justina

Manczak

Winkler

et al. 2014

RBEB

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Introduction: Areas of the brain that are associated with the vestibular system can be activated using galvanic vestibular stimulation. These areas can be studied through a combination of galvanic vestibular stimulation with functional magnetic resonance imaging (fMRI). In order to provide an appropriate sequence of galvanic stimulation synchronous with the MRI pulse sequence, a specific electronic device that was built and assessed is presented. Methods: The electronic project of the GVS is divided in analog and digital circuits. The analog circuits are mounted in an aluminum case, supplied by sealed batteries, and goes inside the MRI room near to the feet of the subject. The digital circuits are placed in the MRI control room. Those circuits communicate through each other by an optical fiber. Tests to verify the GVS-MRI compatibility were conducted. Silicone (in-house) and Ag/AgCl (commercial) electrodes were evaluated for maximum balance and minimal pain sensations. fMRI experiments were conducted in eight human volunteers. Results: GVS-MRI compatibility experiments demonstrate that the GVS did not interfere with the MRI scanner functionality and vice versa. The circular silicone electrode was considered the most suitable to apply the galvanic vestibular stimulation. The 1 Hz stimulation sinusoid frequency produced the biggest balance and the less pain sensations when compared to 2 Hz. The GVS was capable of eliciting activation in the precentral and postcentral gyri, in the central sulcus, in the supplementary motor area, in the middle and inferior frontal gyri, in the inferior parietal lobule, in the insula, in the superior temporal gyrus, in the middle cingulate cortex, and in the cerebellum. Conclusion:This study shows the development and description of a neurovestibular stimulator that can be safely used inside the MRI scanner room without interfering on its operation and vice versa. The developed GVS could successfully activate the major areas involved with multimodal functions of the vestibular system, demonstrating its validity as a stimulator for neurovestibular research. To the best of our knowledge, this is the first work that shows the development and the construction of a galvanic vestibular stimulator that could be safely used inside the MRI room.

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Section: Discussionsupporting

confidence: 91%

Galvanic vestibular stimulator for fMRI studies

Della-Justina

Manczak

Winkler

et al. 2014

RBEB

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“…A vestibular contribution to self-location seems of relevance here because the sensations of elevation and floating reported by the participants of Ionta et al's study are close to vestibular illusions reported by patients with damage to the otolithic vestibular system and the central vestibular structures (Schilder, 1935). Several regions of the TPJ located around the posterior end of the Sylvian fissure, such as the angular, supramarginal and superior temporal gyrus, and the regions located in the depth of the Sylvian fissure, such as the parietal operculum, insula and the retroinsular cortex, are strongly involved in vestibular processing (Chen, DeAngelis, & Angelaki, 2010;Grüsser, Pause, & Schreiter, 1990;Lopez, Blanke, & Mast, 2012). Lesions or seizures in the TPJ may alter the experience of self-location, such as during what are often called out-of-body experiences.…”

Section: Neural Bases Of Whole-body Ownership and Self-locationmentioning

confidence: 55%

Bodily ownership and self-location: Components of bodily self-consciousness

Serino

Alsmith

Costantini

et al. 2013

Consciousness and Cognition

212

170

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a b s t r a c tRecent research on bodily self-consciousness has assumed that it consists of three distinct components: the experience of owning a body (body ownership); the experience of being a body with a given location within the environment (self-location); and the experience of taking a first-person, body-centered, perspective on that environment (perspective). Here we review recent neuroimaging studies suggesting that at least two of these components-body ownership and self-location-are implemented in rather distinct neural substrates, located, respectively, in the premotor cortex and in the temporo-parietal junction. We examine these results and consider them in relation to clinical evidence from patients with altered body perception and work on a variety of multisensory, body-related illusions, such as the rubber hand illusion, the full body illusion, the body swap illusion and the enfacement illusion. We conclude by providing a preliminary synthesis of the data on bodily self-consciousness and its neural correlates.

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“…Despite the obvious importance of vestibular signals, the cortical organization of the vestibular system is not yet well established. Unlike other sensory systems, the number of vestibular cortical areas and the information they represent are still under debate (Dieterich and Brandt 2015;Guldin and Grüsser 1998;Kahane et al 2003;Lopez and Blanke 2011;Lopez et al 2012).…”

Section: In This Paper We Examine Vestibular and Visual Processing Atmentioning

confidence: 99%

“…For the definition of area PIVC, in addition to previous descriptions (e.g., Deutschländer et al 2002;Dieterich et al 2003;Eickhoff et al 2006;Lopez and Blanke 2011;Lopez et al 2012;zu Eulenburg et al 2012), results of a random-effects group analysis of the vestibular localizer were used (Fig. 3C).…”

Section: Imaging Data Analysismentioning

confidence: 99%

Visual-vestibular processing in the human Sylvian fissure

Frank

Wirth

Greenlee

2016

Journal of Neurophysiology

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Frank SM, Wirth AM, Greenlee MW. Visual-vestibular processing in the human Sylvian fissure. J Neurophysiol 116: 263-271, 2016. First published April 13, 2016 doi:10.1152/jn.00009.2016.-Unlike other sensory systems, the cortical organization of the human vestibular system is not well established. A central role is assumed for the region of the posterior Sylvian fissure, close to the posterior insula. At this site, activation during vestibular stimulation has been observed in previous imaging studies and labeled as the parieto-insular vestibular cortex area (PIVC). However, vestibular responses are found in other parts of the Sylvian fissure as well, including a region that is referred to as the posterior insular cortex (PIC). The anatomical and functional relationship between PIC and PIVC is still poorly understood, because both areas have never been compared in the same participants. Therefore, to better understand the apparently more complex organization of vestibular cortex in the Sylvian fissure, we employed caloric and visual object motion stimuli during functional magnetic resonance imaging and compared location and function of PIVC and PIC in the same participants. Both regions responded to caloric vestibular stimulation, but only the activation pattern in right PIVC reliably represented the direction of the caloric stimulus. Conversely, activity in PIVC was suppressed during stimulation with visual object motion, whereas PIC showed activation. Area PIC is located at a more posterior site in the Sylvian fissure than PIVC. Our results suggest that PIVC and PIC should be considered separate areas in the vestibular Sylvian network, both in terms of location and function. area PIC; area PIVC; caloric vestibular stimulation; Sylvian fissure; vestibular cortex NEW & NOTEWORTHY In this paper we examine vestibular and visual processing at the center of human vestibular cortex in the Sylvian fissure. We find that two areas, referred to as parietoinsular vestibular cortex (PIVC) and posterior insular cortex (PIC), are located in the Sylvian fissure and exhibit different functional specializations. Our results suggest a more complex organization at the putative core of human vestibular cortex than previously assumed.A CENTRAL FUNCTION OF THE vestibular sensory system is to signal our position and acceleration in space. This information is of critical relevance for guiding locomotion and for process- There is accumulating evidence that the potential hub of the cortical vestibular network is located in a region including the posterior part of the Sylvian fissure (also called lateral sulcus), perisylvian cortex, and the posterior insula. At this site, functional imaging studies in humans found activation during vestibular stimulation (Bense et al. 2001;Dieterich et al. 2003;Eickhoff et al. 2006;Fasold et al. 2002;Lobel et al. 1998) and labeled it the parieto-insular vestibular cortex (PIVC), following terminology in the primate brain (Akbarian et al. 1988;Chen et al. 2010;Grüsser et al. 1990; Shinder and Newlands 2014...

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The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis

Cited by 386 publications

References 129 publications

Galvanic vestibular stimulator for fMRI studies

Galvanic vestibular stimulator for fMRI studies

Bodily ownership and self-location: Components of bodily self-consciousness

Visual-vestibular processing in the human Sylvian fissure

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