The human Y chromosome: an evolutionary marker comes of age

Jobling, Mark A.; Tyler‐Smith, Chris

doi:10.1038/nrg1124

Cited by 830 publications

(702 citation statements)

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“…Enough markers are available to provide useful discriminating power in individual identification work, and the geographical differentiation of Y haplotypes [1] means that information about the population-of-origin of the donor of a given Y chromosome can often be deduced.…”

Section: Introductionmentioning

confidence: 99%

26-Locus Y-STR typing in a Bhutanese population sample

Parkin

Kraayenbrink

Driem

et al. 2006

Forensic Science International

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Abstract26 Y-chromosome short tandem repeat (STR) loci were amplified in a sample of 856 unrelated males from Bhutan, using two multiplex polymerase chain reaction (PCR) assays. The first multiplex is the Y-STR 20plex described by Butler et al. (2002), and the second is a novel (but overlapping) 14plex that targets six additional Y-STRs (DYS425, DYS434, DYS435, DYS436, DYS461, DYS462) and also amplifies the amelogenin locus. The 26 loci give a discriminating power of 0.9957, though even at this resolution one haplotype occurs 24 times. We identify novel alleles at five loci, and microvariants at a further three, which were characterised by sequencing. haplotypes for these samples have been submitted to the Y-STR Haplotype Reference Database.3

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Section: Introductionmentioning

confidence: 99%

26-Locus Y-STR typing in a Bhutanese population sample

Parkin

Kraayenbrink

Driem

et al. 2006

Forensic Science International

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“…The structure of this new tree mirrors previous trees, which were based on 100-fold fewer SNVs 3,4,6 . However, the wealth of information provided by both the large number of Y chromosomes and variants included in the current study further refine the tree and provide new insight into human population dynamics.…”

Section: Tracing Human Historymentioning

confidence: 68%

The history of the Y chromosome in man

Hughes

Page

2016

Nat Genet

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Bustamante and colleagues in this issue 1 extends this narrative legacy, and ensures that it will continue well into the future. Why the Y?The Y chromosome is home to the testis-determining gene Sry, which causes fetuses to develop as anatomic males. The Y and its meiotic partner, the X, thereby qualify as sex chromosomes.But here the ironies begin. Across 95% of its length (all but its pseudoautosomal tips) the Y chromosome abstains from sexual recombination -the exchange of genes -with the X. This has been true throughout the history (and long before the origin) of our species. Thus the great bulk of the Y chromosome has been transmitted clonally -asexually -from father to son down the generations, its content shaped only by mutation and selection, without swapping genetic material with a partner during meiotic cell division, as occurs on all other nuclear chromosomes,

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“…As haploid genomes, like those contained in the Y-chromosome and mtDNA, represent one quarter of the effective population size when compared with autosomes, 85 they are more subject to genetic drift, drop out events and founder effects, which may partly account for the apparent absence of any haplogroup lineages in common between India and Australia. Even if these uniparental haplogroups were not completely lost, it is possible that any existing Indian Y lineages are so underrepresented in the Indian and/or Australian gene pools that they have not been sampled or that the populations analyzed and referenced by Hudjashov et al 28 were not impacted by the proposed recent Indian migratory event.…”

Section: Discussionmentioning

confidence: 99%