The Huon Peninsula Endemic: Iv. Endemic Goitre and Congenital Defect

McCullagh, S. F.

doi:10.5694/j.1326-5377.1963.tb23449.x

Cited by 22 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence of an overall correlation between visible goitre rate and the incidence of cretinism was obtained, which supports previous evidence from the Huon Peninsula (McCullagh, 1963b ;Hennessy, 1964). This is also consistent with the South American data of Greenwald (1959), who noted a striking correlation between the incidence of goitre and deaf-mutism in Pem and Argentina.…”

Section: Discussionsupporting

confidence: 90%

“…The clinical picture of endemic cretinism, characterized by deaf-mutism, mental deficiency and signs of pyramidal lesions, is identical with that previously reported by McCullagh (1963b) and Choufoer et alt:i (1965) in smaller series of cases. The clinical features are also very similar to those reported by Lobo et alii (1963) from Brazil, who also noted diffuse electroencephalographic abnormalities in 10 of their patients.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Endemic Cretinism in Eastern New Guinea

Hetzel

1969

Australasian Annals of Medicine

View full text Add to dashboard Cite

SUMMARY A study has been carried out of the clinical features, epidemiology and thyroid function in 254 cases of endemic cretinism in Eastern New Guinea. The clinical picture resembles closely that described for Western New Guinea and other endemic goitre areas throughout the world. Goitre was encountered more commonly in mothers of cretins than in adult females of the studied population. Examination of thyroid function revealed a significantly lower serum PBI value and I uptake in cretins when compared with neurologically normal natives. No clinical evidence of hypothyroidism was encountered in endemic cretins, and no biosynthetic defect was isolated as shown by perchlorate discharge testing and chromatography of I131 labelled thyroid glands and serum. Mothers of 13 cretins, born since the introduction of iodized oil prophylaxis, were identified, and in only one instance was there a possibility that iodine therapy had been given. These findings suggest that the condition is related to iodine deficiency and may be prevented by correction of maternal iodine deficiency.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Endemic Cretinism in Eastern New Guinea

Hetzel

1969

Australasian Annals of Medicine

View full text Add to dashboard Cite

show abstract

“…The efficacy of iodine interventions (by lipiodol injection, oral supplement, or iodized salt) for the prevention of deficiency is well established by the results of numerous controlled trials [43][44][45][46][47][48][49][50][51][52][53][54]. In these, iodine has been shown to prevent the various health consequences of iodine deficiency by a reduction in the frequency of irreversible outcomes and/or by an improvement among those populations having reversible consequences.…”

Section: Iodine What Is Known From Efficacy Trialsmentioning

confidence: 99%

Lessons from Successful Micronutrient Programs Part III: Program Impact

Mason¹,

Deitchler²,

Mathys³

et al. 2004

Food Nutr Bull

View full text Add to dashboard Cite

Micronutrient-deficiency control programs have been greatly extended at the national level in the last 10 to 15 years. However, rigorous evaluations of these are scarce, so that conclusions on impact are tentative and based mainly on indirect evidence. The coverage of vitamin A capsule distribution programs has exceeded 70% in most study countries. In countries implementing national iodized salt programs, the coverage reaches 60% to 90% of households with adequately iodized salt. Of the three micronutrients, coverage of iron tablet supplementation is the least well documented due to inadequate program monitoring systems and population survey data. Supplementation of preschool children 6 to 59 months of age with vitamin A capsules has plausibly contributed to the reduction in clinical vitamin A deficiency and its near-elimination in many countries. The impact of vitamin A capsule supplementation on children's biochemical vitamin A status (serum retinol) in national programs may be less. National data on salt iodization show a consistent relation to reduced prevalence of iodine-deficiency disorder symptoms (goiter); the rates of cretinism and other results of iodine deficiency are almost certainly falling too. The evaluation of the impact of salt iodization programs on biochemical iodine status is limited by a lack of data. Although trials have demonstrated the efficacy of iron supplementation in reducing the prevalence of anemia, the interpretation of national-level data is not so clear. Given the substantial financial and technical commitment required to implement national micronutrient-deficiency control programs, it is vital that investment enable the evaluation of the impact of these programs. It is becoming increasingly important to collect data on subclinical deficiency (e.g., biochemical data) to assess program impact.

show abstract

Studies of endemic cretinism in Papua New Guinea: Digital and palmar dermatoglyphic patterns

Larrick¹,

Plato

Hornabrook³

1983

American J Phys Anthropol

View full text Add to dashboard Cite

We have tested the hypothesis that the abnormal development of the central nervous system seen in endemic cretinism might be accompanied by concurrent abnormal dermatoglyphic patterns. We compared digital and palmar dermatoglyphics of normal individuals and endemic cretins inhabiting the Huon Peninsula of Papua New Guinea. The population sampled from the Irumu River Valley included 118 males and 114 females with 22 male cretins and 23 female cretins. The population sampled from the Wantoat River Valley included 72 males and 38 females with 12 male cretins. No pathognomonic patterns were found that could identify the endemic cretin subpopulation. However, the occurrence of a number of differences between controls and cretins suggests that subtle changes in dermatoglyphic patterns accompany the anomalous development of the CNS secondary to maternal iodine deficiency. We discuss the significance of these findings and compare the dermatoglyphic patterns of normal Irumu and Wantoat natives and 21 other populations of Papua New Guinea.

show abstract

The Huon Peninsula Endemic: Iv. Endemic Goitre and Congenital Defect

Cited by 22 publications

References 7 publications

Endemic Cretinism in Eastern New Guinea

Endemic Cretinism in Eastern New Guinea

Lessons from Successful Micronutrient Programs Part III: Program Impact

Studies of endemic cretinism in Papua New Guinea: Digital and palmar dermatoglyphic patterns

Contact Info

Product

Resources

About