“…The voltage-gated proton channel H v 1 is a member of the family of voltage-gated ion channels ( Ramsey et al., 2006 ; Sasaki et al., 2006 ). H v 1 channel plays roles in the regulation of reactive oxygen species (ROS) production by the NADPH oxidase and cellular pH homeostasis ( DeCoursey, 2016 ; Ma et al., 2022 ; Seredenina et al., 2015 ; Taylor et al., 2011 ; Wu et al., 2022 ); it was found in many cell types including airway epithelia cells ( Cherny et al., 1995 ; DeCoursey and Cherny, 1995 ; Fischer, 2012 ; Murphy et al., 2005 ), sperm cells ( Lishko et al., 2010 ; Zhao et al., 2018 , 2021b ), brain microglia ( Peng et al., 2021 ; Wu et al., 2012 ), and cancer cells ( Fernandez et al., 2016 ; Ribeiro-Silva et al., 2016 ; Wang et al., 2011 , 2012 , 2013 ), in which H v 1 activity has been implicated in the pathology of asthma, sperm capacitation, ischemic stroke, and tumor metastasis.…”