2022
DOI: 10.1113/jp282126
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The HVCN1 voltage‐gated proton channel contributes to pH regulation in canine ventricular myocytes

Abstract: support-information-section).

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Cited by 14 publications
(13 citation statements)
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References 84 publications
(220 reference statements)
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“…H V 1 is thought to form ion channels activated by voltage and employing a mechanism of activation similar to the VSDs of canonical voltage-gated potassium, sodium, and calcium channels ( Gonzalez et al, 2012 ). The functions of H V 1 channels are diverse, including intracellular pH regulation ( Ma et al, 2022 ), charge compensation during immune response ( Ramsey et al, 2009 ), modulation of flagellar beating in spermatozoa ( Lishko and Kirichok, 2010 ), bioluminescence ( Eckert and Sibaoka, 1968 ), and possible roles in calcification processes in marine organisms ( Taylor et al, 2011 ; Rangel-Yescas et al, 2021 ). Also, H V 1 is involved in different pathologies such as B cell malignancy ( Hondares et al, 2014 ), breast cancer ( Wang et al, 2012 ), and post-ischemic brain injury ( Wu, 2014 ; Yu et al, 2020 ); consequently, in recent years, H V 1 has emerged as a possible pharmacological target ( Zhao et al, 2018 ; Zhang et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…H V 1 is thought to form ion channels activated by voltage and employing a mechanism of activation similar to the VSDs of canonical voltage-gated potassium, sodium, and calcium channels ( Gonzalez et al, 2012 ). The functions of H V 1 channels are diverse, including intracellular pH regulation ( Ma et al, 2022 ), charge compensation during immune response ( Ramsey et al, 2009 ), modulation of flagellar beating in spermatozoa ( Lishko and Kirichok, 2010 ), bioluminescence ( Eckert and Sibaoka, 1968 ), and possible roles in calcification processes in marine organisms ( Taylor et al, 2011 ; Rangel-Yescas et al, 2021 ). Also, H V 1 is involved in different pathologies such as B cell malignancy ( Hondares et al, 2014 ), breast cancer ( Wang et al, 2012 ), and post-ischemic brain injury ( Wu, 2014 ; Yu et al, 2020 ); consequently, in recent years, H V 1 has emerged as a possible pharmacological target ( Zhao et al, 2018 ; Zhang et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…3-(2-amino-5-methyl-1H-imidazol-4-yl)-1- (3,5-difluorophenyl) propan-1-one, HIF and 2-aminobenzimidazole, ABI) (Zhao et al, 2021), which have been proven to be effective Hv1 inhibitors in a number of paradigms (Asuaje et al, 2017;Ma et al, 2022;Meszaros et al, 2020;Zhao et al, 2021). Guanidine derivatives, such as ClGBI, are effective inhibitors at low micromolar concentrations, and have a low toxicity profile.…”
Section: Introductionmentioning
confidence: 99%
“…The voltage-gated proton channel H v 1 is a member of the family of voltage-gated ion channels ( Ramsey et al., 2006 ; Sasaki et al., 2006 ). H v 1 channel plays roles in the regulation of reactive oxygen species (ROS) production by the NADPH oxidase and cellular pH homeostasis ( DeCoursey, 2016 ; Ma et al., 2022 ; Seredenina et al., 2015 ; Taylor et al., 2011 ; Wu et al., 2022 ); it was found in many cell types including airway epithelia cells ( Cherny et al., 1995 ; DeCoursey and Cherny, 1995 ; Fischer, 2012 ; Murphy et al., 2005 ), sperm cells ( Lishko et al., 2010 ; Zhao et al., 2018 , 2021b ), brain microglia ( Peng et al., 2021 ; Wu et al., 2012 ), and cancer cells ( Fernandez et al., 2016 ; Ribeiro-Silva et al., 2016 ; Wang et al., 2011 , 2012 , 2013 ), in which H v 1 activity has been implicated in the pathology of asthma, sperm capacitation, ischemic stroke, and tumor metastasis.…”
Section: Introductionmentioning
confidence: 99%