2016
DOI: 10.1080/19336918.2015.1093275
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The hydatidiform mole

Abstract: The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with the former being followed by an endoreplication of the male pronucleus leading to a complete hydatidiform mole (CHM) 2. A triploid zygote (fertilization by 2 spermatozoa) leading to a partial hyd… Show more

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Cited by 71 publications
(79 citation statements)
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“…LOI is directly linked with abnormal embryonic development, as demonstrated by the inability of parthenogenetic and androgenetic conceptuses to survive past early stages of gestation, by which they can be transformed into tumors in human (Linder et al , ; Kajii & Ohama, ; Fig ). These tumors are comprised of distinct tissues, which in the case of parthenogenetic ovarian teratoma includes disorderly embryonic structures of the three germ layers (Stamp & McConnell, ), while androgenetic hydatidiform mole constitutes cells of extraembryonic origin (Candelier, ). Further studies in mouse chimeras confirmed that lacking either the maternal or paternal genomes contributes to the formation of discrete cell types, recapitulating the bias toward embryonic and trophoblast tissues exhibited in bimaternal and bipaternal embryos, respectively (Thomson & Solter, ).…”
Section: Introductionmentioning
confidence: 99%
“…LOI is directly linked with abnormal embryonic development, as demonstrated by the inability of parthenogenetic and androgenetic conceptuses to survive past early stages of gestation, by which they can be transformed into tumors in human (Linder et al , ; Kajii & Ohama, ; Fig ). These tumors are comprised of distinct tissues, which in the case of parthenogenetic ovarian teratoma includes disorderly embryonic structures of the three germ layers (Stamp & McConnell, ), while androgenetic hydatidiform mole constitutes cells of extraembryonic origin (Candelier, ). Further studies in mouse chimeras confirmed that lacking either the maternal or paternal genomes contributes to the formation of discrete cell types, recapitulating the bias toward embryonic and trophoblast tissues exhibited in bimaternal and bipaternal embryos, respectively (Thomson & Solter, ).…”
Section: Introductionmentioning
confidence: 99%
“…However, invasive hydatidiform mole has malignant tumor behavior and can undergo extensive metastasis . If left untreated it can be transformed into choriocarcinoma with poor prognosis, which can lead to significant morbidity and mortality . Therefore, early diagnosis of invasive hydatidiform mole is critical for rapid and accurate treatment management.…”
Section: Introductionmentioning
confidence: 99%
“…Our own case is similar; the extra copy of chromosome 9 is maternal in origin, and both microsatellite and SNP genotyping data are consistent with a dispermic origin of the CHM. The occurrence of the postzygotic diploidization of triploids and karyotype instability and its cytogenetic implications in the formation of a hydatidiform mole had been described by Golubovsky, Sunde and Candelier . Thus, the most likely mechanism to explain this complex result is the dispermic fertilization of a single oocyte followed by the abnormal division of the zygote, with endoreduplication of one paternal pronucleus leading to postzygotic diploidization .…”
Section: Discussionmentioning
confidence: 92%