The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4?-dihydroxydiphenyl-(pyridyl-2)-methane

Förth, W.; Nell, G.; Rummel, W.; Andres, H.

doi:10.1007/bf00501005

Cited by 30 publications

(25 citation statements)

References 6 publications

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“…In the present study, the laxative effects of FRe were evaluated based on changes in fecal parameters (numbers, weight and water content), the gastrointestinal transit ratio (motility), fecal mucus content, number of colonic mucus-producing cells and the mean colonic mucosa thickness in rats with loperamide-induced constipation, used as a model of spastic constipation (11). The laxative effects of FRe were compared with those of S. picosulfate, a cathartic stimulant that requires activation by colonic bacteria (19,20), as a reference drug (21). …”

Section: Discussionmentioning

confidence: 99%

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Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Choi

Kim²,

Cho³

et al. 2014

Experimental and Therapeutic Medicine

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Constipation is a common problem in males and females. The aim of the present study was to evaluate the laxative effects of fermented rice extract (FRe) on rats with loperamide-induced constipation. FRe (100, 200 and 300 mg/kg) was administered orally once per day for six days following 1 h loperamide treatment. The laxative effects of FRe were compared with those of sodium picosulfate (S. picosulfate). Following the induction of constipation in the rats, a marked decrease was observed in the fecal pellet number and water content discharged over 24 h, the surface mucus thickness in the colonic lumen, intestinal charcoal transit ratio, thickness of the colonic mucosa and the number of mucus-producing cells, while an increase was observed in the number of fecal pellets remaining in the colonic lumen and their mean diameter, as compared with the normal vehicle control rats. These conditions were significantly alleviated following the administration of the three doses of FRe when compared with the loperamide control group. However, the alleviating effects were lower than those of S. picosulfate, with the exception of the intestinal charcoal transit ratio. Similar effects on the intestinal charcoal transit ratio were detected for the three doses of FRe when compared with the S. picosulfate-treated rats. In conclusion, the results indicated that FRe exhibits a laxative effect without causing diarrhea, as compared with sodium picosulfate; thus, FRe may be effective as a complementary medicine in patients suffering from lifestyle-induced constipation.

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Section: Discussionmentioning

confidence: 99%

“…The laxative effects of FRe were compared with those of 5 mg/kg sodium picosulfate (S. picosulfate), a cathartic stimulant that requires activation by colonic bacteria (19,20), as a reference drug (21). …”

Section: Introductionmentioning

confidence: 99%

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Choi

Kim²,

Cho³

et al. 2014

Experimental and Therapeutic Medicine

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“…presumably by the intestinal bacteria. The sulfate ester causes more prompt laxative action than the free drug (24). presumably because the polar sulfate derivative is not absorbed and reaches the lower level bowel promptly where it is hydrolyzed by the flora to release the active compound.…”

Section: Catharticsmentioning

confidence: 98%

Biochemical Pharmacology of the Intestinal Flora

Goldman¹

1978

Annu. Rev. Pharmacol. Toxicol.

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Animal and bacteriological techniques have been developed for clarifying the role of the flora in the metabolism of drugs and other exogenous compounds. In general the flora tends to catalyze reductive and hydrolytic reactions, some of which reverse the detoxification reactions normally occurring in the liver. These reactions and others have been implicated in the pharamacological or toxicological action of exogenous compounds. Only in a few instances, however, have practical consequences of these reactions been documented. The major challenge at present is to develop methods capable of further defining the implications of reactions due to the flora.

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“…In this context it is of interest that a laxative has been manufactured where a sulfuric acid ester of bisacodyl has been synthesized (21). This compound is not absorbed in the small intestine similarly to the glucuronide.…”

Section: Availability O F Laxatives In the Colonmentioning

confidence: 99%

The Physiological Basis of Laxative Action

Ewe¹

1980

Pharmacology

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The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4?-dihydroxydiphenyl-(pyridyl-2)-methane

Cited by 30 publications

References 6 publications

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Biochemical Pharmacology of the Intestinal Flora

The Physiological Basis of Laxative Action

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