The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats

Mora, Sergio; Millán, Raquel; Lungenstrass, H.; Dı́az-Véliz, Gabriela; Morán, Juan; Herrera-Ruíz, Maribel; Tortoriello, Jaime

doi:10.1016/j.jep.2005.12.004

Cited by 45 publications

(31 citation statements)

References 17 publications

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“…Fluoxetine (10 mg/kg), test compounds (100 mg/kg) and control solution (sunflower oil) were applied via intraperitoneal (i.p) route for three times; 24, 5 and 0.5 h before the applications of the tests [18,26].…”

Section: Chemicals and Administration Of The Compoundsmentioning

confidence: 99%

New pyrazoline derivatives and their antidepressant activity

Kaplancıklı

Özdemir

Turan-Zitouni

et al. 2010

European Journal of Medicinal Chemistry

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Section: Chemicals and Administration Of The Compoundsmentioning

confidence: 99%

New pyrazoline derivatives and their antidepressant activity

Kaplancıklı

Özdemir

Turan-Zitouni

et al. 2010

European Journal of Medicinal Chemistry

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“…Depression constitutes the second most common chronic condition in clinical practice (Whooley and Simon 2000) and could become the second leading cause of premature death or disability worldwide by the year 2020 (WHO 1999). Approximately two-thirds of anxious or depressed patients respond to the currently available treatments but the magnitude of improvement is still disappointing (Mora et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effect of chlorogenic acid isolated fromArtemisia capillarisThunb.

Park

Sim

Han

et al. 2010

Animal Cells and Systems

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Artemisia capillaris Thunb. is widely used in the herbal medicine field. This study describes the antidepressant effect of a flavonoid (chlorogenic acid) isolated from the Artemisia capillaris Thunb. The expression of the pituitary gland and hypothalamic POMC mRNA or plasma b-endorphin levels were increased by extract of Artemisia capillaris Thunb. or its flavoniod administered orally. In addition, antidepressant activity was studied using the tail suspension test (TST), the forced swimming test (FST) and the rotarod test in a chronically restrained immobilization stress group in mice. After restraint stress (2 h/day for 14 days), animals were kept in a cage for 14 days without any further stress, but with drugs. Mice were fed with a diet supplemented for 14 days and during the behavioral test period with chlorogenic acid (30 mg/kg/day). POMC mRNA or the plasma b-endorphin level was increased by the extract of Artemisia capillaris Thunb. and its flavoniod. In addition, the immobility time in TST and FST was significantly reduced by chlorogenic acid. In the rotarod test, the riding time remained similar to that of the control group at 15 rpm. Our results suggest that the flavonoid (chlorogenic acid) isolated from Artemisia capillaris Thunb. shows a potent antidepressant effect.

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“…1 Salvia (commonly called sage) belongs to the mint family Laminaceae (Labiateae) and contains about 900 species all over the world. [2][3][4] One of the largely used sage species in medicine is S. libanotica, a species endemic to the eastern Mediterranean. 5,6 Oil and water extracts from S. libanotica have been used for many years by locals and villagers to cure ailments such as abdominal pains, headaches, indigestions and heart disorders.…”

Section: Introductionmentioning

confidence: 99%