The hydrolysis of saponin-rich extracts from fenugreek and quinoa improves their pancreatic lipase inhibitory activity and hypocholesterolemic effect

Hierro, Joaquín Navarro del; Casado-Hidalgo, Gema; Reglero, Guillermo; Martín, Diana

doi:10.1016/j.foodchem.2020.128113

Cited by 36 publications

(27 citation statements)

References 38 publications

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“…Recently, a phytochemical study conducted to identify the bioactive constituents of H. hirsuta has shown that the aerial part of this plant is rich in phenolic compounds ( Figure 7 a,b) [ 171 ]. According to the literature, these compounds are well known for various pharmacological effects [ 175 , 176 , 177 , 178 , 179 ]. Therefore, the antilithiasic activity of H. hirsuta may be due to the presence of these compounds.…”

Section: Resultsmentioning

confidence: 99%

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Bencheikh

Elbouzidi

Kharchoufa

et al. 2021

Plants

153

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Kidney disease is one of the most common health problems and kidney failure can be fatal. It is one of the health disorders associated with extreme pain and discomfort in patients. In developing countries, such as Morocco where socioeconomic and sanitary conditions are precarious, medicinal plants are considered the primary source of medication. In the present work an ethnobotanical survey was conducted in a remote area of North-Eastern Morocco and we focused on (1) establishing a record of medicinal plants used traditionally by local people to treat kidney diseases and (2) correlate the obtained ethnomedical use with well-studied pharmacological evidence. From February 2018 to January2020, information was gathered from 488 informants using semi-structured questionnaires. The data were analyzed using three quantitative indices: The use value (UV), family use value (FUV), and informant consensus factor (ICF). A total of 121 plant species belonging to 57 botanical families were identified to treat kidney diseases. The families most represented were Asteraceae (14 species), followed by Lamiaceae (12 species) and Apiaceae (10 species). The most commonly used plant parts were leaves, followed by the whole plant and they were most commonly prepared by decoction and infusion. The highest value of the (UV) index was attributed to Herniaria hirsuta L. (UV = 0.16), and the highest family use value (FUV) was assigned to Caryophyllaceae with (FUV = 0.163). Regarding the informant consensus factor (ICF), this index’s highest values were recorded for kidney stones (ICF = 0.72). The use of 45% of the selected plants were validated based on literature review. This study helped document and preserve crucial traditional plant knowledge of 121 plant species used to treat kidney problems that can be used in the search for new biologically active compounds through more upcoming pharmacological studies.

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Section: Resultsmentioning

confidence: 99%

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Bencheikh

Elbouzidi

Kharchoufa

et al. 2021

Plants

153

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“…In addition, all dispersions hydrolyzed by PLP had a smaller mean hydrodynamic diameter compared with the unhydrolyzed ones, with a particle size distribution showing the only prominent peak in the region of 100–1000 nm. Overall, it is seen that hydrolysis contributed to a size decrease in yolk fractions, whereas PLP seemed more destructive than LP, owing to its effects on their protein structure [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative Study on Foaming Properties of Egg White with Yolk Fractions and Their Hydrolysates

Wang²,

Sun

et al. 2021

Foods

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As an excellent foaming agent, egg white protein (EWP) is always contaminated by egg yolk in the industrial processing, therefore, decreasing its foaming properties. The aim of this study was to simulate the industrial EWP (egg white protein with 0.5% w/w of egg yolk) and characterize their foaming and structural properties when hydrolyzed by two types of esterase (lipase and phospholipase A2). Results showed that egg yolk plasma might have been the main fraction, which led to the poor foaming properties of the contaminated egg white protein compared with egg yolk granules. After hydrolyzation, both foamability and foam stability of investigated systems thereof (egg white protein with egg yolk, egg white protein with egg yolk plasma, and egg white protein with egg yolk granules) increased significantly compared with unhydrolyzed ones. However, phospholipids A2 (PLP) seemed to be more effective on increasing their foaming properties as compared to those systems hydrolyzed by lipase (LP). The schematic diagrams of yolk fractions were proposed to explain the aggregation and dispersed behavior exposed in their changes of structures after hydrolysis, suggesting the aggregated effects of LP on yolk plasma and destructive effects of PLP on yolk granules, which may directly influence their foaming properties.

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“…The cholesterol-lowering effect of saponins and sapogenins has been widely described in literature regarding the treatment of hyperlipidemia. Navarro Del Hierro et al 77 found that saponin-rich extracts and their hydrolysates from fenugreek and quinoa can inhibit PL activity. Although the exact role of sapogenins contained in the hydrolyzed extracts in lipase inhibition remains unclear, the study provided a potential baseline for the development of multi-bioactive products that act against pancreatic lipase and cholesterol absorption simultaneously.…”

Section: The Pharmacological Mechanism Underlying the Use Of Diosgenin For Treatment Of Hyperlipidemiamentioning

confidence: 99%

The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review

Sun

Yang

et al. 2021

DMSO

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Hyperlipidemia is a disorder of lipid metabolism, which is a major cause of coronary heart disease. Although there has been considerable progress in hyperlipidemia treatment, morbidity and risk associated with the condition continue to rise. The first-line treatment for hyperlipidemia, statins, has multiple side effects; therefore, development of safe and effective drugs from natural products to prevent and treat hyperlipidemia is necessary. Diosgenin is primarily derived from fenugreek ( Trigonella foenum graecum ) seeds, and is also abundant in medicinal herbs such as Dioscorea rhizome, Dioscorea septemloba , and Rhizoma polygonati , is a well-known steroidal sapogenin and the active ingredient in many drugs to treat cardiovascular conditions. There is abundant evidence that diosgenin has potential for application in correcting lipid metabolism disorders. In this review, we evaluated the latest evidence related to diosgenin and hyperlipidemia from clinical and animal studies. Additionally, we elaborate the pharmacological mechanism underlying the activity of diosgenin in treating hyperlipidemia in detail, including its role in inhibition of intestinal absorption of lipids, regulation of cholesterol transport, promotion of cholesterol conversion into bile acid and its excretion, inhibition of endogenous lipid biosynthesis, antioxidation and lipoprotein lipase activity, and regulation of transcription factors related to lipid metabolism. This review provides a deep exploration of the pharmacological mechanisms involved in diosgenin-hyperlipidemia interactions and suggests potential routes for the development of novel drug therapies for hyperlipidemia.

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The hydrolysis of saponin-rich extracts from fenugreek and quinoa improves their pancreatic lipase inhibitory activity and hypocholesterolemic effect

Cited by 36 publications

References 38 publications

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Comparative Study on Foaming Properties of Egg White with Yolk Fractions and Their Hydrolysates

The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review

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