The hydroxyproline content of amnion and prelabour rupture of the membranes

Macdermott, R. I. J.; Landon, Christine

doi:10.1016/s0301-2115(99)00273-0

Cited by 12 publications

(6 citation statements)

References 6 publications

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“…Some studies suggested that foetal membranes grow actively until mid-pregnancy, laying down new collagen. In the last half of pregnancy, research suggests that the membrane no longer grows but stretches to accommodate foetal growth [27]. Other investigators have reported a progressive decrease in amniotic concentrations of collagen towards term.…”

Section: Resultsmentioning

confidence: 99%

Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Longini

Perrone

Vezzosi

et al. 2007

Clinical Biochemistry

123

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Section: Resultsmentioning

confidence: 99%

Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Longini

Perrone

Vezzosi

et al. 2007

Clinical Biochemistry

123

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“…Skinner et al (1981) report a significantly lower collagen content in the amnion from PROM membranes compared to membranes ruptured at term. In contrast, MacDermott and Landon (2000) found that there is no generalized reduction of the collagen content in the amnion and hypothesizes that PROM is caused by a localized membrane weakness. Apart from that, both studies report a decrease of the collagen content, in the amnion layer, with progressing gestational age.…”

Section: Clinical Relevance Of Findingsmentioning

confidence: 92%

Multiaxial mechanical behavior of human fetal membranes and its relationship to microstructure

Buerzle

Haller

Jabareen

et al. 2012

Biomech Model Mechanobiol

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This study was directed to the measurement of the mechanical response of fetal membranes to physiologically relevant loading conditions. Characteristic mechanical parameters were determined and their relation to the microstructural constituents collagen and elastin as well as to the pyridinium cross-link concentrations analyzed. 51 samples from twelve fetal membranes were tested on a custom-built inflation device, which allows mechanical characterization within a multiaxial state of stress. Methods of nonlinear continuum mechanics were used to extract representative mechanical parameters. Established biochemical assays were applied for the determination of the collagen and elastin content. Collagen cross-link concentrations were determined by high-performance liquid chromatography measurements. The results indicate a distinct correlation between the mechanical parameters of high stretch stiffness and membrane tension at rupture and the biochemical data of collagen content and pyridinoline as well as deoxypyridinoline concentrations. No correlation was observed between the mechanical parameters and the elastin content. Moreover, the low stretch stiffness is, with a value of 105 ± 31 × 10(-3) N/ mm much higher for a biaxial state of stress compared to a uniaxial stress configuration. Determination of constitutive model equations leads to better predictive capabilities for a reduced polynomial hyperelastic model with only terms related to the second invariant, I 2, of the right Cauchy-Green deformation tensor. Relevant insights were obtained on the mechanical behavior of fetal membranes. Collagen and its cross-linking were shown to determine membrane's stiffness and strength for multiaxial stress states. Their nonlinear deformation behavior characterizes the fetal membranes as I 2 material.

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“…The amniotic fluid pressure of women presenting hydramnios has been found to be ,40% higher than that of healthy patients [35]. 8 One large study [36] amid other contradictory results [37][38][39][40][41][42] tends to confirm this hypothesis.…”

Section: Etiologymentioning

confidence: 99%

“…Several earlier studies [14,38,39,41,42] evaluated the collagen content of amnion (A), chorion (C), and/or chorioamnion (CA), from the tissue hydroxyproline content. Results in the literature and results obtained in this study are shown in Table 3.3.…”

Section: Collagen Content -Collagen Extractabilitymentioning

confidence: 99%

Biomechanics of the human chorioamnion

Prevost¹,

Suresh²,

House³

et al. 2006

Journal of Biomechanics

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The human fetal membrane, namely the chorioamnion, is the structural soft tissue retaining the amniotic fluid and the fetus during pregnancy. Its biomechanical integrity is crucial for maintaining a healthy gestation and a successful delivery. The premature rupture of the fetal membrane (PROM) can result in serious perinatal complications. Despite extensive research in this field, the mechanical and biochemical processes governing the membrane deformation and failure remain poorly understood. The aim of this study is to characterize the mechanical behavior of the chorioamnionic tissue along with its biochemical properties, through mechanical testing and biochemical analyses. In order to accomplish this goal, specific mechanical and biochemical testing protocols were developed. In vitro mechanical testing was performed on samples from seven patients under different uniaxial and biaxial loading conditions. Significant relaxation was noted under uniaxial loading while very limited creep was observed under biaxial loading. Biochemical measurements such as collagen and sulfated glycosaminoglycan contents were also obtained. In addition, a microstructurally based constitutive model for the fetal membrane is proposed. The model allows for nonlinear hyperelastic response at large deformation. We also propose a framework to capture the timedependent response of the tissue. The model was implemented in a finite element formulation to allow three-dimensional simulations of membrane deformation.

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The hydroxyproline content of amnion and prelabour rupture of the membranes

Cited by 12 publications

References 6 publications

Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Multiaxial mechanical behavior of human fetal membranes and its relationship to microstructure

Biomechanics of the human chorioamnion

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