The “hyper-triglyceridemic waist phenotype” is a reliable marker for prediction of accumulation of abdominal visceral fat in Chinese adults

Tian, Yiming; Ma, Ning; Jia, Xiaojiao; Lu, Qiang

doi:10.1007/s40519-019-00677-w

Cited by 12 publications

(14 citation statements)

References 28 publications

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“…According to the current research results, we found that when central obesity and hypertriglyceridemia appeared simultaneously, the risk of NAFLD in the general population would further increase (comparing with NTNW, NTEW, and ETNW; all P < 0.05). This conclusion is also applicable to other metabolism-related diseases [ 14 – 21 ].…”

Section: Discussionmentioning

confidence: 64%

“…In this context, a growing number of scholars have conducted an in-depth analysis of the HTGW phenotype. Many studies have shown that the HTGW phenotype was not only associated with coronary artery disease, but also closely related to pancreatitis, metabolic syndrome, diabetes, pre-diabetes, hyperuricemia, ischemic stroke, chronic nephropathy, and visceral obesity [ 14 – 21 ]. Also, in the recent study by Blackburn et al, it was found that the HTGW phenotype had the same ability to identify adverse metabolic characteristics as the National Cholesterol Education Program-Adult Treatment Panel III standard and International Diabetes Federation (IDF) standard [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study

Yang

et al. 2022

Lipids Health Dis

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Background Hypertriglyceridemic-waist (HTGW) phenotype has been proposed as a practical tool for screening the risk of cardiovascular diseases and glycemic metabolic disease. This study sought to investigate the relationship between HTGW phenotype and non-alcoholic fatty liver disease (NAFLD). Methods A total of 14,251 subjects who took part in health screening were enrolled in the study and NAFLD was diagnosed by abdominal ultrasound. According to triglyceride (TG) and waist circumference, the study population was divided into four phenotypes, in which HTGW phenotype was defined as TG ≥ 1.7 mmol/L and male waist circumference ≥ 90 cm or female waist circumference ≥ 80 cm. Multivariate logistic regression analysis was used to evaluate the relationship between HTGW phenotype and NAFLD. Results In the current study, 2.43% of the subjects had HTGW phenotype, while the prevalence of NAFLD in subjects with HTGW phenotype was 77.81%. After full adjustment for covariates, compared with people with normal waist circumference and TG levels, the risk of NAFLD in people with normal TG levels but enlarged waist circumference increased by 39% [OR:1.39, 95%CI: 1.15, 1.68], in people with normal waist circumference but elevated TG levels increased by 96% [OR:1.96, 95%CI: 1.65, 2.33], and in subjects with HTGW phenotype increased by 160% [OR:2.60, 95%CI: 1.88, 3.58]. Additionally, further analysis suggested that there were significant interactions between age, height, BMI and NAFLD risk associated with TGW phenotypes. Receiver operating characteristic curves analysis suggested that the combination of TG and waist circumference further improved the diagnostic value for NAFLD. Conclusions HTGW phenotype is associated with NAFLD risk in the general population, which may be a novel and accessible indicator for NAFLD screening.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study

Yang

et al. 2022

Lipids Health Dis

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“…Published data have signified that the HTGW phenotype can be used in clinical practice to investigate CVD risk and visceral adipose tissue in individuals [ 11 , 27 ]. The HTGW phenotype has been corroborated to be a surrogate marker for predicting visceral obesity, which is associated with metabolic alterations [ 28 ]. Moreover, it has been reported that the HTGW phenotype is significantly associated with early diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemic waist phenotype and risk of chronic kidney disease in community-dwelling adults aged 60 years and older in Tianjin, China: a 7-year cohort study

Chen

Sun²,

et al. 2021

BMC Nephrol

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Background The hypertriglyceridemic waist (HTGW) phenotype has been proposed to be related to the occurrence and progression of chronic kidney disease (CKD). The ageing trend of the Chinese population continues to intensify, and elderly individuals are at high risk of CKD. The purpose of this study was to investigate the cross-sectional and longitudinal associations between the HTGW phenotype and the risk of CKD by following community-dwelling adults aged 60 years and older in Tianjin, China, for 7 years. Methods This study was an observational cohort study conducted between 2013 and 2019. Of 2050 participants aged 60 years and older who underwent an annual health examination in 2013, 1605 individuals with complete data were enrolled in the cross-sectional analysis. Among them, 1271 individuals were observed until 2019. Detailed follow-up records were available for 816 participants, of whom 600 participants without CKD at baseline were eligible for inclusion in the retrospective analysis. The HTGW phenotype was defined as a waist circumference of 90 cm or more and triglyceride concentrations of 2.0 mmol/L or more in males or a waist circumference of 85 cm or more and triglyceride concentrations of 1.5 mmol/L or more in females. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 and/or proteinuria (urinary albumin-to-creatinine ratio (ACR) ≥ 30 mg/g). Multivariable logistic regression analyses were performed to evaluate the relationship between the HTGW phenotype and CKD. Results In 2013, the prevalence of CKD among older adults was 31.03%, and the prevalence of CKD in the HTGW phenotype group was 37.81%. Over a 7-year observation period, 195 individuals developed CKD, with an incidence rate of 32.50%. Statistically significant associations were observed between the HTGW phenotype and CKD in older adults in both cross-sectional surveys and retrospective analyses, with odds ratios and 95% confidence intervals of 1.38 (95% CI: 1.03–1.86, P = 0.033) and 2.27 (95% CI: 1.30–3.97, P = 0.004), respectively, after adjustment for confounders. Conclusions In this community-based cohort study, the HTGW phenotype was confirmed to be independently associated with an increased risk of prevalent and incident CKD in older adults aged 60 years and above in Tianjin, China.

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“…Currently, only computed tomography (CT) and magnetic resonance imaging (MRI) can accurately measure the content of visceral fat (23)(24)(25), but these imaging techniques are not suitable for health screening in large populations because of the high cost and radiation exposure. Since the measurement of WC alone is ineffective in distinguishing between subcutaneous and visceral adipose tissues (26), the concept of hypertriglyceridemic waist phenotype (HTWP) (defined as coexisting hypertriglyceridemia and an elevated WC) was put forward by Lemieux et al (27) to solve the abovementioned problem, which was used as a simple marker to identify individuals with metabolic abnormalities and increased visceral fat (28)(29)(30). To date, two prospective studies have shown that HTWP is associated with an increased risk of ischemic stroke (31, 32).…”

Section: Introductionmentioning

confidence: 99%

“…Since the measurement of WC alone is ineffective in distinguishing between subcutaneous and visceral adipose tissues ( 26 ), the concept of hypertriglyceridemic waist phenotype (HTWP) (defined as coexisting hypertriglyceridemia and an elevated WC) was put forward by Lemieux et al. ( 27 ) to solve the abovementioned problem, which was used as a simple marker to identify individuals with metabolic abnormalities and increased visceral fat ( 28 – 30 ). To date, two prospective studies have shown that HTWP is associated with an increased risk of ischemic stroke ( 31 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

Hypertriglyceridemic waist phenotype: Association with initial neurological severity and etiologic subtypes in patients with acute ischemic stroke

Ren

Qiu

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the relationship of hypertriglyceridemic waist phenotype (HTWP) with initial neurological severity and etiologic subtypes in patients with acute ischemic stroke.MethodsThe data for this study were collected from hospitalized patients within 72 h of acute ischemic stroke onset at the Department of Neurology of the Affiliated Hospital of Beihua University from 1 July 2020 to 30 June 2022. The initial neurological severity was assessed by the National Institute of Health Stroke Scale (NIHSS) on the day of admission: NIHSS <6 was defined as mild stroke, and NIHSS ≥6 as moderate to severe stroke. HTWP was defined by fasting serum triglycerides ≥1.7 mmol/L and waist circumference ≥90 cm in men and ≥80 cm in women. Differentiation of etiologic subtypes was based on the method reported in the Trial of Org 10 172 in Acute Stroke Treatment. Multivariate logistic regression analysis was used to analyze the association of HTWP with initial neurological severity and etiologic subtypes.ResultsThe study included 431 patients. Compared with the normal waist–normal blood triglyceride group, patients with HTWP had reduced risks of moderate to severe stroke [odds ratio (OR): 0.384, 95% confidence interval (CI): 0.170–0.869; P = 0.022]. In addition, the risk of small-artery occlusion stroke was 2.318 times higher in the HTWP group than in the normal triglyceride–normal waist (NWNT) group (OR: 2.318, 95% CI: 1.244–4.319; P = 0.008).ConclusionInitial neurological severity was less severe in patients with HTWP, and HTWP was associated with an increased risk of small-artery occlusion stroke.

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The “hyper-triglyceridemic waist phenotype” is a reliable marker for prediction of accumulation of abdominal visceral fat in Chinese adults

Cited by 12 publications

References 28 publications

Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study

Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study

Hypertriglyceridemic waist phenotype and risk of chronic kidney disease in community-dwelling adults aged 60 years and older in Tianjin, China: a 7-year cohort study

Hypertriglyceridemic waist phenotype: Association with initial neurological severity and etiologic subtypes in patients with acute ischemic stroke

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