The hypermethylation of <i>FOXP3</i> gene as an epigenetic marker for the identification of arsenic poisoning risk

Ma, Lu; Fang, Xiaolin; Zhang, Aihua

doi:10.1177/09603271221142819

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…The predictive value of the column line chart model was evaluated using the Harrell concordance index. 18 …”

Section: Methodsmentioning

confidence: 99%

Prognostic Factors and Construction of Nomogram Prediction Model of Lung Cancer Patients Using Clinical and Blood Laboratory Parameters

Zhang,

Wan,

Shen

et al. 2024

OTT

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Objective This work aimed to explore the prognostic risk factors of lung cancer (LC) patients and establish a line chart prediction model. Methods A total of 322 LC patients were taken as the study subjects. They were randomly divided into a training set (n = 202) and a validation set (n = 120). Basic information and laboratory indicators were collected, and the progression-free survival (PFS) and overall survival (OS) were followed up. Single-factor and cyclooxygenase (COX) multivariate analyses were performed on the training set to construct a Nomogram prediction model, which was validated with 120 patients in the validation set, and Harrell’s consistency was analyzed. Results Single-factor analysis revealed significant differences in PFS ( P <0.05) between genders, body mass index (BMI), carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), squamous cell carcinoma antigen (SCCA), treatment methods, treatment response evaluation, smoking status, presence of pericardial effusion, and programmed death ligand 1 (PD-L1) at 0 and 1–50%. Significant differences in OS ( P <0.05) were observed for age, tumor location, treatment methods, White blood cells (WBC), uric acid (UA), CA125, pro-gastrin-releasing peptide (ProGRP), SCCA, cytokeratin fragment 21 (CYFRA21), and smoking status. COX analysis identified male gender, progressive disease (PD) as treatment response, and SCCA > 1.6 as risk factors for LC PFS. The consistency indices of the line chart models for predicting PFS and OS were 0.782 and 0.772, respectively. Conclusion Male gender, treatment response of PD, and SCCA > 1.6 are independent risk factors affecting the survival of LC patients. The PFS line chart model demonstrates good concordance.

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“…The predictive value of the column line chart model was evaluated using the Harrell concordance index. 18 …”

Section: Methodsmentioning

confidence: 99%

Prognostic Factors and Construction of Nomogram Prediction Model of Lung Cancer Patients Using Clinical and Blood Laboratory Parameters

Zhang,

Wan,

Shen

et al. 2024

OTT

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“…El efecto sumatorio de estos eventos promueve el aumento de las concentraciones de citocinas proinflamatorias (IL-1β e IL-6) y disminución de las citocinas antiinflamatorias (IL-4 e IL-10), daño al ADN o al ARN, atrofia en organelos (núcleo, mitocondrias y retículo endoplasmático principalmente) y formación de poros en la membrana plasmática, promoviendo muerte celular tipo autofagia, piroptosis, apoptosis, o necrosis, lo cual explica la infiltración de células inflamatorias, alteraciones morfológicas en hepatocitos, aumento del contenido de colágeno e inicio de fibrosis (Ma et al, 2022)…”

Section: Efectos Citotóxicosunclassified

Efecto citotóxico de iones metálicos

Hernández-Baltazar,

Rivadeneyra-Domínguez,

Pensado-Guevara

et al. 2024

UVserva

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Los iones metálicos con actividad biológica como el cobalto, cobre, cromo, hierro y magnaneso participan en la nutrición, respiración, mantenimiento y comunicación celular. Otros iones como el arsénico, cadmio, mercurio y plomo, que si bien son importantes para la dinámica de suelos y ecosistemas, no son parte del mantenimiento de la homeostásis celular, por el contrario su acumulación exacerbada en el organismo puede favorecer alteraciones patofisiológicas. En los últimos años, la exposición a iones metálicos tóxicos ha ido en aumento debido a su consumo en alimentos, o por exposición ambiental u ocupacional, favoreciéndo patologías a nivel de sistema respiratorio, gastrointestinal, músculo esquelético y sistema nervioso. En órganos de la cavidad abdominal como el hígado y riñón, así como torácicos (pulmón y corazón), los efectos tóxicos son evidentes por la presencia de atrofia celular, edemas e inflamación. A nivel del Sistema Nervioso Central, la neurotoxicidad inducida por iones metálicos se caracteriza por estrés celular exacerbado, neurodegeneración y neuroinflamación. La falla órganica sistémica en combinanción con daño neuronal podría generar disfunción metabólica asociada a desregulación en la síntesis y liberación de neurotransmisores, lo cual podría derivar en alteraciones cognitivas y motoras. En este artículo presentamos una breve revisión del impacto de iones metálicos como el cobalto, cobre, cromo y hierro en la supervivencia celular; y en contraste, el efecto citotóxico del arsénico, cadmio, mercurio y plomo; asimismo, las estrategias usadas para la detección de intoxicación mediante análisis clínico y métodos espectroscópicos o de genómica usados en investigación científica. Cytotoxic effect of metal ions: A brief review Metal ions such as cobalt, copper, chromium, iron and manganese are involved in nutrition, respiration, maintenance and cell communication. However, heavy metal such as arsenic, cadmium, mercury and lead, which are key for soil dynamics, are not necessary to maintain homeostasis. On the contrary, exacerbated levels of heavy metals in cells induce morphophysiological alterations. Till date, exposure to metal ions has been increasing due to their consumption in junk food; due to environmental or occupational exposure favoring respiratory, gastrointestinal, skeletal muscle and neurological diseases. In peritoneal organs such as the liver and kidney, or thoracic organs for example in lung and heart, the toxic effects are evident by the presence of cell atrophy, edema and inflammation. At the central nervous system level, metal ion-induced neurotoxicity is characterized by increased cellular stress, neurodegeneration and neuroinflammation. The combination of systemic organ failure and neuronal damage might lead to metabolic dysfunction and deregulation in the synthesis and release of neurotransmitters, which could further generate cognitive and motor alterations. In this article, we, for the first time present a brief review of the impact of metal ions, such as cobalt, copper, chromium, iron, as key agents for cell survival. In contrast, the cytotoxic effect of arsenic, cadmium, mercury and lead; furthermore, the strategies used for the metal ions-based intoxication detection by clinical analysis or new methods used in scientific research.

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“…In addition to the PTMs mentioned above, methylation of transcription factors or co-stimulatory factors is also important for the regulation of gene expression ( 99 ). Altered methylation of Foxp3 is linked with the onset of multiple diseases ( 100 , 101 ) ( Figure 2D ). The main sites of methylation modification are arginine and lysine residues ( 102 ).…”

Section: Methylation Modification Of Foxp3mentioning

confidence: 99%

Targeting post-translational modifications of Foxp3: a new paradigm for regulatory T cell-specific therapy

Riaz,

Huang,

Pan

2023

Front. Immunol.

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A healthy immune system is pivotal for the hosts to resist external pathogens and maintain homeostasis; however, the immunosuppressive tumor microenvironment (TME) damages the anti-tumor immunity and promotes tumor progression, invasion, and metastasis. Recently, many studies have found that Foxp3+ regulatory T (Treg) cells are the major immunosuppressive cells that facilitate the formation of TME by promoting the development of various tumor-associated cells and suppressing the activity of effector immune cells. Considering the role of Tregs in tumor progression, it is pivotal to identify new therapeutic drugs to target and deplete Tregs in tumors. Although several studies have developed strategies for targeted deletion of Treg to reduce the TME and support the accumulation of effector T cells in tumors, Treg-targeted therapy systematically affects the Treg population and may lead to the progression of autoimmune diseases. It has been understood that, nevertheless, in disease conditions, Foxp3 undergoes several definite post-translational modifications (PTMs), including acetylation, glycosylation, phosphorylation, ubiquitylation, and methylation. These PTMs not only elevate or mitigate the transcriptional activity of Foxp3 but also affect the stability and immunosuppressive function of Tregs. Various studies have shown that pharmacological targeting of enzymes involved in PTMs can significantly influence the PTMs of Foxp3; thus, it may influence the progression of cancers and/or autoimmune diseases. Overall, this review will help researchers to understand the advances in the immune-suppressive mechanisms of Tregs, the post-translational regulations of Foxp3, and the potential therapeutic targets and strategies to target the Tregs in TME to improve anti-tumor immunity.

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The hypermethylation of FOXP3 gene as an epigenetic marker for the identification of arsenic poisoning risk

Cited by 4 publications

References 47 publications

Prognostic Factors and Construction of Nomogram Prediction Model of Lung Cancer Patients Using Clinical and Blood Laboratory Parameters

Prognostic Factors and Construction of Nomogram Prediction Model of Lung Cancer Patients Using Clinical and Blood Laboratory Parameters

Efecto citotóxico de iones metálicos

Targeting post-translational modifications of Foxp3: a new paradigm for regulatory T cell-specific therapy

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