The hypoglossal–facial nerve repair as a method to improve recovery of motor function after facial nerve injury

Özsoy, Umut; Hizay, Arzu; Demirel, Bahadır; Özsoy, Özlem; Sarikcioglu, Sureyya Bilmen; Turhan, Murat; Sarıkcıoğlu, Levent

doi:10.1016/j.aanat.2011.01.009

Cited by 31 publications

(24 citation statements)

References 105 publications

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“…Facial palsy, with the loss of facial expression, is a social problem that leads to significant deterioration in quality of life [1,2]. It can compromise any verbal communication conveyed by facial expressions which is essential to social relationships, for example, a spontaneous and dynamic smile that is essential in community interaction [3,4].…”

Section: Introductionmentioning

confidence: 99%

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

et al. 2016

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This study aimed to evaluate the effects of low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve with two surgical techniques: end-to-end epineural suture and coaptation with heterologous fibrin sealant. Forty-two male Wistar rats were randomly divided into five groups: control group (CG) in which the buccal branch of the facial nerve was collected without injury; (2) experimental group with suture (EGS) and experimental group with fibrin (EGF): The buccal branch of the facial nerve was transected on both sides of the face. End-to-end suture was performed on the right side and fibrin sealant on the left side; (3) Experimental group with suture and laser (EGSL) and experimental group with fibrin and laser (EGFL). All animals underwent the same surgical procedures in the EGS and EGF groups, in combination with the application of LLLT (wavelength of 830 nm, 30 mW optical power output of potency, and energy density of 6 J/cm(2)). The animals of the five groups were euthanized at 5 weeks post-surgery and 10 weeks post-surgery. Axonal sprouting was observed in the distal stump of the facial nerve in all experimental groups. The observed morphology was similar to the fibers of the control group, with a predominance of myelinated fibers. In the final period of the experiment, the EGSL presented the closest results to the CG, in all variables measured, except in the axon area. Both surgical techniques analyzed were effective in the treatment of peripheral nerve injuries, where the use of fibrin sealant allowed the manipulation of the nerve stumps without trauma. LLLT exhibited satisfactory results on facial nerve regeneration, being therefore a useful technique to stimulate axonal regeneration process.

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Section: Introductionmentioning

confidence: 99%

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

et al. 2016

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“…Since the late 19th century, surgical crossover neurotization of the damaged facial nerve was attempted using the phrenic nerve, glossopharyngeal nerve, contralateral facial nerve, spinal accessory nerve, and hypoglossal nerve (9,14,26,27,47). Due to the undesirable side effects following the sacrifice of the phrenic and glossopharyngeal nerves (9) and the lower rate of efficacy reported for the spinal accessory and the contralateral facial nerves' usage as donor nerves (1,25,27,38,48), HFA remains the preferred technique for properly selected patients (11,29,30).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Direct Side-to-End and End-to-End Hypoglossal-Facial Anastomosis for Facial Nerve Repair

et al. 2015

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“…FN injury is commonplace in accidents or cerebellopontine angle (CPA) surgery 2. In addition, FN dysfunction can result from diseases, and approximately 20% of Bell’s palsy patients experience permanent damage 3…”

Section: Introductionmentioning

confidence: 99%

“…Surgical transposition of the hypoglossal nerve (HN) is the most commonly used procedure for innervating the FN distal stump 2. Since classic HN–FN end-to-end neurorrhaphy causes serious neurological deficits resulting from the sacrifice of the HN, surgical interventions have been improved by transferring half of the HN to the injured FN, either directly or via a nerve graft 4.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, regenerative therapies represent an important challenge. Two major obstacles most likely contribute to the poor reparative outcomes: a long waiting period before repair surgery, resulting in unfavourable changes in the injured FN and atrophy of its target muscles,5 and a cellular environment poorly supportive of nerve regeneration 2 6 7. Waiting for spontaneous recovery before repair surgery is indeed associated with a reduced benefit of treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

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Hypoglossal–facial nerve ‘side’-to-side neurorrhaphy using a predegenerated nerve autograft for facial palsy after removal of acoustic tumours at the cerebellopontine angle

Zhang

Wan

et al. 2014

J Neurol Neurosurg Psychiatry

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The hypoglossal–facial nerve repair as a method to improve recovery of motor function after facial nerve injury

Cited by 31 publications

References 105 publications

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

Comparison of Direct Side-to-End and End-to-End Hypoglossal-Facial Anastomosis for Facial Nerve Repair

Hypoglossal–facial nerve ‘side’-to-side neurorrhaphy using a predegenerated nerve autograft for facial palsy after removal of acoustic tumours at the cerebellopontine angle

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