The hypolipidaemic activity of aqueous Erica multiflora flowers extract in Triton WR-1339 induced hyperlipidaemic rats: A comparison with fenofibrate

Harnafi, Hicham; Bouanani, Nour El Houda; Aziz, Mohammed; Serghini-Caíd, Hana; Ghalim, Noreddine; Amrani, Souliman

doi:10.1016/j.jep.2006.09.017

Cited by 64 publications

(50 citation statements)

References 20 publications

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“…Data from Ericaceae species is difficult to compare due to its environmental conditions. However, the results of phytochemical analysis obtained are in good agreement with data reported by some authors (Akkol et al, 2008;Harnafi et al, 2007), which have detected the presence of flavonoids, tannins, proanthocyanidins, coumarins on Ericaceae species.…”

Section: Resultssupporting

confidence: 92%

Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts

Puertas-Me¹,

Rincon-Val²,

Mejia-Gira³

2015

Research J. of Medicinal Plant

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The UV solar radiation accelerates skin aging, leading to loss of skin elasticity and decreasing the capacity of the skin to hold water, which are implicated in the formation of the most obvious sign of aging, skin wrinkling and related health problems in humans. Usually, synthetic sunscreens have been used to minimize these effects. However, some phenolic compounds present in plants play an important role as photoprotectors. The aim of this study was to explore the potential of three plants from Ericaceae family as UVA-UVB filters and its antioxidant capacity. Leaf extracts of B. aestuans, C. bracteata and C. pubescence showed an interesting broad-spectrum UVB/UVA absorption that was correlated with the antioxidant capacity (from 1.96E-04-3.75E-04 mg µmolG 1 DPPH), the TPC value (from 15.29-27.35 mg GAE gG 1 DS) and TAC value (0.36-3.31 mg C3GE gG 1 DS). According to these results, the three plants evaluated in this research could be considered as a potential source of natural compounds with UV absorption and antioxidant capacity.

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Section: Resultssupporting

confidence: 92%

Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts

Puertas-Me¹,

Rincon-Val²,

Mejia-Gira³

2015

Research J. of Medicinal Plant

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“…In this study, high cholesterol was induced in mice by adding cholesterol (2%) and coconut oil (25%) to the diet for 36 days. This finding is in agreement with other ISSN 2157-6076 2012 www.macrothink.org/jbls 49 investigators who support that high fat diet resulted in hypercholesterolemia such as significant increase in plasma total cholesterol, LDL-C, triglycerides and hepatic oxidative damage ( Berrougui ET Al., 2003, Harnafi ET Al., 2007& Rui ET Al., 2008. Furthermore, these results are in close agreement with previous study carried out in animals fed with fats, in which the hypercholesterolemic effect was attributed to saturated fatty acids occurring in coconut oil ( Uehara ET Al., 2002& Garcia-Fuentes ET Al., 2002.…”

Section: Discussionmentioning

confidence: 99%

“…flavonoids) to penetrate the lipid membranes constituted with phospholipids ( Gladine ET Al.,2007). In fact, ubiquitous plant polyphenols such as flavonoids, have exhibited a variety of pharmacological activities, including the anti-atherogenesis effect, and their role in prevention of coronary heart disease including atherosclerosis (Harnafi, ET Al.,2007), and have been demonstrated to inhibit lipid peroxidation, and increasing glutathione peroxidase concentrations that have been shown to play a protective role against oxidative damage in various tissues by neutralizing reactive oxygen species ( Wellwood ET Al.,2004& Olaleye ET Al.,2008. Further, several authors have also reported that flavonoids have hypolipidemic and hypocholesteromic effects ( Sharma ET Al., 2008).…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

“…The increase HDL-C concentration could protect the LDL against oxidation in vivo because lipids in HDL are preferentially oxidized before those in LDL (El-Beshbishy ET Al., 2006). Hypercholesterolemia or more specifically elevated plasma LDL-cholesterol is an important risk factor for development and progression of atherosclerosis ( Harnafi ET Al., 2007) which is accompanied by the production of free radicals by endothelial and vascular smooth muscles. These free radicals initiate processes involved in atherogenesis through several important enzyme systems, including xanthine oxidase, nicotinamide adenine dinucleotide phosphaste (NADP), oxidases and nitric oxide synthase.…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

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The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(-68.57%), low density lipoprotein (LDL) (-56.34%), and triglycerides (TG) (-182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

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“…This effect might be due to increase in hydrolysis of triglycerides into its component glycerol and fatty acids by lipoprotein lipase in the endothelium. [35][36][37][38] The lowering of TG,TC , LDL-C and VLDL cholesterol in serum would reduce the incidence of coronary events. 39,40, Among the doses administered ,only 600 mg/kg significant decreased serum lipid levels .…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic Effect of EthanolicExtract of Cyperus esculentumis in TritonWR-1339-Induced Hyperlipidemic Rats

Ubhenin

2017

IJFMI

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ORIGINAL ARTICLECurrently, there has been an observed interest in phytochemicals as a new hypolipidemic agents to replace synthetic toxic hypolipidemic drugs. The investigation was carried out to evaluate the hypolipidemic effects of ethanolicextract of Cyperus esculentumis in triton-induced hyperlipidemic rats. The ethanolic extract of the plant was administered orally to rats at the doses of 300,400 and 600mg/kg body weight for a period of twenty nine days in accordance with the Ethical committee on experimental animals. Hyperlipidemia was developed by interaperitoneal injection of Triton at a dose 250mg/kg b.wt. to wistar rats . Intraperitoneal injection of Triton WR-1339 at a dose of 250mg/kg to rats resulted in the increase in serum triglyceride, total cholesterol , low density and very low density lipoproteins cholesterol accompanied by reduction in the high density lipoprotein cholesterol .The histopathological examination also revealed that there were remarkable histopathological changes in the aorta and artery of rats induced with Triton WR-1339 . The damages were manifested as ulceration and stenosis .Pretreatment with the ethanolic tuber extract of Cyperus esculentumis led to significant reduction of TC, TG, LDL and VLDL cholesterol in triton-induced hyperlipidemic rats as compared to the control. There was also an increased in HDL-cholesterol and attenuation of histopathological damages. Among the different doses administered, only 600 mg/kg exhited statistical significant effects. Other doses 300 and 400mg/kg showed mild toxicity. This finding suggests that the cholesterol-lowering effect of Cyperus esculentumis may be due to the enhancement of LDL-C metabolism which might be attributed to the presence of the valuable phytochemicals in the extract. Keywords

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The hypolipidaemic activity of aqueous Erica multiflora flowers extract in Triton WR-1339 induced hyperlipidaemic rats: A comparison with fenofibrate

Cited by 64 publications

References 20 publications

Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts

Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Hypolipidemic Effect of EthanolicExtract of Cyperus esculentumis in TritonWR-1339-Induced Hyperlipidemic Rats

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