The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to lipolysis or LDL receptor binding

Man, Frits H.A.F. de; Beer, F. de; Laarse, Arnoud van der; Jansen, Hans; Leuven, J.A. Gevers; Souverijn, J.H.M.; Vroom, Ton F.F.P.; Schoormans, S.C.M.; Fruchart, Jean‐Charles; Havekes, Louis M.; Smelt, A.H.M.

doi:10.1016/s0021-9150(00)00409-3

Cited by 17 publications

(14 citation statements)

References 42 publications

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“…This observation has been in line with the previous reports on the effects of this compound on LPL activity in PHP [45,46]. Recently, it has been reported that series of statins, such as pravastatins, atorvastatins and pitavastatins may produce a significant increase in serum LPL mass after the treatment [47,48].…”

Section: Effects Of Several Lipid-lowering Agents On Serum Lpl Masssupporting

confidence: 92%

Serum lipoprotein lipase mass: Clinical significance of its measurement

Kobayashi

Nohara

Kawashiri

et al. 2007

Clinica Chimica Acta

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Section: Effects Of Several Lipid-lowering Agents On Serum Lpl Masssupporting

confidence: 92%

Serum lipoprotein lipase mass: Clinical significance of its measurement

Kobayashi

Nohara

Kawashiri

et al. 2007

Clinica Chimica Acta

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“…This observation has been in line with the previous reports on the effects of this compound on LPL activity in PHP (26,27). Troglitazone, an insulin sensitizer, has also been reported to cause an increase in pre-heparin LPL mass (29), which is consistent with our study showing this agent increased LPL mass in PHP (30).…”

Section: Effects Of Several Lipid-lowering Agents On Pre-heparin Lpl supporting

confidence: 93%

“…It has been shown that bezafibrate, a lipid-lowering compound known to cause a reduction in serum TG level and an increase in HDL-C levels (25)(26)(27), has produced a considerable increase in pre-heparin LPL mass in hypertriglyceridemic patients (28). This observation has been in line with the previous reports on the effects of this compound on LPL activity in PHP (26,27).…”

Section: Effects Of Several Lipid-lowering Agents On Pre-heparin Lpl supporting

confidence: 84%

Pre-heparin Lipoprotein Lipase Mass

Kobayashi

2004

JAT

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Lipoprotein lipase (LPL) is a lipolytic enzyme involved in catalyzing the hydrolysis of triglycerides (TG) in chylomicrons and very low-density lipoprotein (VLDL) particles. Over the last decade, the clinical significance of measuring LPL mass without heparin injection has been increasingly studied. In earlier studies, it was shown that this marker was utilized to classify type 1 hyperlipoproteinemia, which is an extremely rare metabolic disorder. Later, researchers paid more attention to the clinical significance of measuring this parameter in more common metabolic disorders. Studies have shown that pre-heparin plasma LPL mass has significant relationships with serum lipid and lipoproteins, visceral fat area, and even a marker for acute inflammation, although this might be a metabolic surrogate marker which does not appear to be involved in catalyzing the hydrolysis of TG in TG-rich lipoproteins. We suggest that pre-heparin LPL mass in plasma or sera provides us with useful and important information on the pathophysiology of metabolic disorders or acute inflammation despite its simplicity from a practical point of view. J Atheroscler Thromb, 2004; 11: 1-5.

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“…Fibrates and their derivatives including bezafibrate are class of drugs widely used to treat hypertriglyceridemia [10]. Bezafibrate significantly reduces serum triglyceride and free fatty acid levels [11]. The major mechanism of fibrates is by the induction of lipoprotein lipase and efficient reduction of apolipoprotein C-III-containing particles, which are markers for increased risk of atherosclerosis [12][13][14].…”

Section: Introductionmentioning

confidence: 99%