The hypolipidemic, anti-inflammatory and antioxidant effect of Kavolì® aqueous extract, a mixture of Brassica oleracea leaves, in a rat model of NAFLD

Assessment of the Antioxidant and Hypolipidemic Properties of Salicornia europaea for the Prevention of TAFLD in Rats

“…This, in turn, leads to progressive peroxidation and subsequent damage to hepatic tissues. In particular, some products of lipid peroxidation and the free radical generated can also affect tissue macromolecules, including proteins [15,17,53]. Compared to CCl 4 group, the CCl 4 + SAL group showed significantly lower values of carbonylated proteins and TBARS, comparable to those observed for CTR group, thus demonstrating that pretreatment with S. europaea was able to mitigate the oxidative stress induced by carbon tetrachloride [15,17].…”

“…Interestingly, the values obtained were much greater than those reported in one of our recent investigations involving a leafy variety of Brassica oleracea, a species well known for its great antioxidant properties, in which we found a mean ORAC value of 14.9 µmol TE/g dw. [53]. All in all, these analyses suggest that the younger leaves are richer in bioactive compounds and pigments and, consequently, have a stronger antioxidant activity compared to their mature counterparts, thus resulting much more suitable for being used in the in vivo experimental study to test its potential health benefits.…”

“…These distinct histopathological features observed among the four experimental groups align with the previously mentioned values of blood biochemical parameters, such as blood transaminases and blood fats (Table 3). Numerous studies have highlighted the antioxidant potential of plant extracts and polyphenol-rich vegetables in improving the hepatic lipid accumulation triggered by both fatty diets and toxicants [17,53]. Specifically, some isolated polyphenols, including phenolic acids and flavonoids such as chlorogenic acid and quercetin derivatives, have demonstrated efficacy in reducing liver lipid content in the presence of various toxicants and high-fat diets [15,17,53].…”

“…Numerous studies have highlighted the antioxidant potential of plant extracts and polyphenol-rich vegetables in improving the hepatic lipid accumulation triggered by both fatty diets and toxicants [17,53]. Specifically, some isolated polyphenols, including phenolic acids and flavonoids such as chlorogenic acid and quercetin derivatives, have demonstrated efficacy in reducing liver lipid content in the presence of various toxicants and high-fat diets [15,17,53]. These beneficial compounds, abundantly found in halophyte plants, help improve fat metabolism in the liver [15,17].…”

“…Recent research explored the use of polyphenol-enriched extracts from the fruits and seeds Sarcopoterium spinosum in an in vitro model of hepatic steatosis, showcasing their potential to counteract lipid accumulation and improve hepato-steatosis [78]. Furthermore, much research has focused on the importance of extracts enriched with polyphenols and their implication in the molecular mechanisms of lipid-lowering action, as could be the case of Salicornia extract [53,78,79].…”