The <i>Arachis hypogaea</i> Essential Oil Nanoemulsion as an Efficient Safe Apoptosis Inducer in Human Lung Cancer Cells (A549)

Fazelifar, Parastoo; Tabrizi, Masoud Homayouni; Rafiee, Aras

doi:10.1080/01635581.2020.1783330

Cited by 17 publications

(6 citation statements)

References 60 publications

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“…The rising SubG1 peaks and the overexpression of Caspase 3 show that AHO-NE causes apoptosis in A549 cells. Additionally, it has antioxidant action (ABTS IC50: 270.42 lg/mL; DPPH IC50: 208.51 lg/mL) (Fazelifar et al, 2021). Another research discovered that Resveratrol (RV) in peanut stem extract (PSE) showed that both RV and PSE dose-dependently induced cell death in DOC-2/DAB2 interactive protein (DAB2IP) deficient prostate cancer (PCa) cells with the radioresistant phenotype.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profile and Biological Activities of Ethylacetate Extract of Peanut (Arachis hypogaea L.) Stems: In-Vitro and In-Silico Studies with Bibliometric Analysis

Sahidin

Nohong

Manggau

et al. 2022

Indonesian J. Sci. Technol

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The utilization of the stems, leaves, and hulls of peanuts (Arachis hypogea) is not as popular as the seeds. This study aimed to investigate the chemical contents and pharmacological activities of A. hypogaea stems in-vitro and in-silico. This study was also completed with bibliometric analysis. The methanol extract (ME) was reextracted by ethylacetate to get ethyl acetate extract (EAE). The chemical contents of EAE were analyzed by phytochemical screening, Liquid Chromatography-Mass Spectroscopy (LC-MS/MS), TPC (Total Phenolic Content), and TFC (Total Flavonoid Content). In-vitro and in-silico studies evaluated antioxidant potency, toxicity, and cytotoxicity toward MCF-7 cell lines. The results showed that EAE contained terpenoids, flavonoids, alkaloids, and phenolics which were supported by LC-MS/MS data. The EAE was categorized as a very strong antioxidant and moderately active in both cytotoxicity and toxicity.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Profile and Biological Activities of Ethylacetate Extract of Peanut (Arachis hypogaea L.) Stems: In-Vitro and In-Silico Studies with Bibliometric Analysis

Sahidin

Nohong

Manggau

et al. 2022

Indonesian J. Sci. Technol

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“…Arachis hypogaea A549 Anti-cancer, apoptosis (Fazelifar et al, 2021) Reviewing some of the research papers on the anti-cancer properties of EOs concerning lung cancer cells reveals that there are different types of EOs, and that the mechanism of action is effective with different types of lung cancer cell lines, as revealed by the review. The cytotoxic effect of essential oils on cancer cell lines is the most frequently seen action method.…”

Section: Nomentioning

confidence: 99%

Essential Oils as Alternative Halal Therapeutic Source for Lung Cancer: A Mini Review

Abdullah

Hazahari

Amid

2022

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The global Muslim population is predicted to grow significantly. The market for Halal products, an obligation for Muslims, is expanding in sync with the Muslim population. Cancer is a notable cause of death globally. Pharmaceuticals are the most important fundamental component because they are disease-specific, most notably cancer-specific. Optional pharmaceuticals were looked into to meet Muslim demand for Halal products. Some essential oils are viable therapeutic sources because they have long been used in conventional medicine for various treatments. The purpose of this study is to review the investigation done on the potential for essential oils to be used as a Halal alternative therapy for lung cancer. This mini review follows the traditional narrative review study. According to these researches, essential oils are helpful in the treatment of malignancies, notably lung cancer. However, additional research, including clinical trials, is essential to enhance the treatment's efficacy.

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“…These findings suggest that CLNE could act as a potential strategy for the management of brain disease/disorders like neuroblastoma Arachis hypogaea oil NE (ANE) was formulated and exhibited improved therapeutic efficacy against A549 lung carcinoma cells by inhibiting the cell viability and also antioxidant activity at 270.42 g/mL and 208.51 g/mL …”

Section: Polyphenols-loaded Nanoemulsion In Cancer Therapymentioning

confidence: 99%

“…The applications of polyphenols have been limited due to their hydrophobic nature and lower oral bioavailability, which can be overcome by encapsulating them into nanoformulations leading to improved anticancer activity. , The creation of nanosystems to improve the physicochemical stability of flavonoids can be done using novel techniques made possible by nanotechnology. , Both oil-in-water (O/W) and water-in-oil (W/O) nanoemulsions (NEs), but particularly O/W types, have been shown to be very successful for the delivery of various lipophilic drugs, enhancing the in vitro activity of chemotherapeutic agents, or improving the bioavailability of flavonoids, but can only encapsulate drugs with similar lipophilicity. , Water-in-oil-in-water (W/O/W) NEs strategies containing lipophilic, hydrophilic, and amphiphilic molecules were developed to get around this restriction . Growing interest recently has been seen in using the principles of structural design to increase the functional performance of products based on emulsions .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Tomar,

Das,

Balaga

et al. 2024

ACS Appl. Bio Mater.

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Cancer is one of the major causes of death worldwide, even the second foremost cause related to non-communicable diseases. Cancer cells typically possess several cellular and biological processes including, persistence, propagation, differentiation, cellular death, and expression of cellular-type specific functions. The molecular picture of carcinogenesis and progression is unwinding, and it appears to be a tangled combination of processes occurring within and between cancer cells and their surrounding tissue matrix. Polyphenols are plant secondary metabolites abundant in fruits, vegetables, cereals, and other natural plant sources. Natural polyphenols have implicated potential anticancer activity by various mechanisms involved in their antitumor action, including modulation of signaling pathways majorly related to cellular proliferation, differentiation, relocation, angiogenesis, metastatic processes, and cell death. The applications of polyphenols have been limited due to the hydrophobic nature and lower oral bioavailability that could be possibly overcome through encapsulating them into nanocarrier-mediated delivery systems, leading to improved anticancer activity. Nanoemulsions (NEs) possess diverse feasible properties, including greater surface area, modifiable surficial charge, higher half-life, site-specific targeting, and formulation imaging capability necessary to create a practical therapeutic impact, and have drawn increased attention in cancer therapy research. This review has summarized and discussed the basic concepts, classification, delivery approaches, and anticancer mechanism of various polyphenols and polyphenols-encapsulated nanoemulsions with improved cancer therapy.

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The Arachis hypogaea Essential Oil Nanoemulsion as an Efficient Safe Apoptosis Inducer in Human Lung Cancer Cells (A549)

Cited by 17 publications

References 60 publications

Phytochemical Profile and Biological Activities of Ethylacetate Extract of Peanut (Arachis hypogaea L.) Stems: In-Vitro and In-Silico Studies with Bibliometric Analysis

Phytochemical Profile and Biological Activities of Ethylacetate Extract of Peanut (Arachis hypogaea L.) Stems: In-Vitro and In-Silico Studies with Bibliometric Analysis

Essential Oils as Alternative Halal Therapeutic Source for Lung Cancer: A Mini Review

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

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