The<i>Aspergillus nidulans rcoA</i>Gene Is Required for<i>veA</i>-Dependent Sexual Development

Todd, Richard B.; Hynes, Michael J.; Andrianopoulos, Alex

doi:10.1534/genetics.106.062893

Cited by 24 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In parallel, the leucine zipper‐like protein DopA is needed for normal asexual sporulation, but sexual reproduction was also completely abolished in a Δ dopA strain (Pascon & Miller, ). In a similar fashion, the WD40 family protein RcoA is required for both normal asexual development and sexuality, as illustrated by the finding that a Δ rcoA strain was completely self‐sterile and unable to form maternal tissues in outcrosses (Todd et al ., ). Overexpression of the veA gene in a Δ rcoA background failed to restore sexual development, indicating that RcoA acts downstream of VeA in development (Fig.…”

Section: Genes Involved With Sexual Development In the Aspergillimentioning

confidence: 97%

Sexual development and cryptic sexuality in fungi: insights fromAspergillusspecies

2012

View full text Add to dashboard Cite

Major insights into sexual development and cryptic sexuality within filamentous fungi have been gained from investigations using Aspergillus species. Here, an overview is first given into sexual morphogenesis in the aspergilli, describing the different types of sexual structures formed and how their production is influenced by a variety of environmental and nutritional factors. It is argued that the formation of cleistothecia and accessory tissues, such as Hülle cells and sclerotia, should be viewed as two independent but co-ordinated developmental pathways. Next, a comprehensive survey of over 75 genes associated with sexual reproduction in the aspergilli is presented, including genes relating to mating and the development of cleistothecia, sclerotia and ascospores. Most of these genes have been identified from studies involving the homothallic Aspergillus nidulans, but an increasing number of studies have now in addition characterized 'sex-related' genes from the heterothallic species Aspergillus fumigatus and Aspergillus flavus. A schematic developmental genetic network is proposed showing the inter-relatedness between these genes. Finally, the discovery of sexual reproduction in certain Aspergillus species that were formerly considered to be strictly asexual is reviewed, and the importance of these findings for cryptic sexuality in the aspergilli as a whole is discussed.

show abstract

Section: Genes Involved With Sexual Development In the Aspergillimentioning

confidence: 97%

Sexual development and cryptic sexuality in fungi: insights fromAspergillusspecies

2012

View full text Add to dashboard Cite

show abstract

“…rcoA mutants also have reduced transcription of the asexual regulator brlA , resulting in reduced asexual conidiation (Hicks et al , 2001). rcoA Δ cannot develop sexual fruiting bodies because they are self‐sterile (Todd et al , 2006). Overexpression of veA in an rcoA mutant background cannot rescue the mutant phenotype of rcoA , suggesting that RcoA might act downstream of VeA in a mechanism that remains to be resolved.…”

Section: Putative Interactors Of Velvet Proteins and Laea In The Contmentioning

confidence: 99%

Coordination of secondarymetabolism and development in fungi: the velvet familyof regulatory proteins

2012

View full text Add to dashboard Cite

Filamentous fungi produce a number of small bioactive molecules as part of their secondary metabolism ranging from benign antibiotics such as penicillin to threatening mycotoxins such as aflatoxin. Secondary metabolism can be linked to fungal developmental programs in response to various abiotic or biotic external triggers. The velvet family of regulatory proteins plays a key role in coordinating secondary metabolism and differentiation processes such as asexual or sexual sporulation and sclerotia or fruiting body formation. The velvet family shares a protein domain that is present in most parts of the fungal kingdom from chytrids to basidiomycetes. Most of the current knowledge derives from the model Aspergillus nidulans where VeA, the founding member of the protein family, was discovered almost half a century ago. Different members of the velvet protein family interact with each other and the nonvelvet protein LaeA, primarily in the nucleus. LaeA is a methyltransferase-domain protein that functions as a regulator of secondary metabolism and development. A comprehensive picture of the molecular interplay between the velvet domain protein family, LaeA and other nuclear regulatory proteins in response to various signal transduction pathway starts to emerge from a jigsaw puzzle of several recent studies.

show abstract

“…Sexual development is also regulated by rcoA (Todd et al, 2006). RcoA shares similarity with S. cerevisiae Tup1p (Keleher et al, 1992) and N. crassa RCO1 (Yamashiro et al, 1996).…”

Section: The Role Of Vea In a Nidulans Morphological Developmentmentioning

confidence: 99%

The VeA regulatory system and its role in morphological and chemical development in fungi

Calvo

2008

Fungal Genetics and Biology

236

266

View full text Add to dashboard Cite

TheAspergillus nidulans rcoAGene Is Required forveA-Dependent Sexual Development

Cited by 24 publications

References 25 publications

Sexual development and cryptic sexuality in fungi: insights fromAspergillusspecies

Sexual development and cryptic sexuality in fungi: insights fromAspergillusspecies

Coordination of secondarymetabolism and development in fungi: the velvet familyof regulatory proteins

The VeA regulatory system and its role in morphological and chemical development in fungi

Contact Info

Product

Resources

About