We report the magnetotransport properties of Bi2Sr2−xLaxCu1−zZnzO 6+δ (Zn-doped BSLCO) single crystals with z of up to 2.2%. Besides the typical Zn-doping effects on the in-plane resistivity and the Hall angle, we demonstrate that the nature of the low-temperature normal state in the Zn-doped samples is significantly altered from that in the pristine samples under high magnetic fields. In particular, we observe nearly-isotropic negative magnetoresistance as well as an increase in the Hall coefficient at very low temperatures in non-superconducting Zn-doped samples, which we propose to be caused by the Kondo scattering from the local moments induced by Zn impurities. PACS numbers: 74.25.Fy, 74.62.Dh, 74.20.Mn, 74.72.Hs Effects of nonmagnetic Zn impurities on the electronic properties of the high-T c cuprates have been intensively studied, employing almost all available experimental tools. However, well-controlled studies of the Zn-doping effects using high-quality single crystals have been mostly limited to the YBa 2 Cu 3 O 7−δ (YBCO) system and the La 2−x Sr x CuO 4 (LSCO) system because of the availability of single crystals; for example, in the otherwise well-studied system of Bi 2 Sr 2 CaCu 2 O 8+δ (Bi-2212), high-quality single crystals can be grown with only up to ∼1% of Zn substitution, posing difficulties for systematic studies. Recently, high-quality single crystals of Bi 2 Sr 2−x La x CuO 6+δ (BSLCO) have become available 1 in a wide range of hole concentrations. 2 It is thus natural to investigate the Zn-doping effect in the BSLCO system to examine and expand our knowledge of the role of Zn impurities in the cuprates. Here we report that Zn-doping of up to 2.2% is possible in high-quality BSLCO crystals and present the effect of Zn impurities on the charge transport properties of this system. One of the most peculiar charge transport properties of the cuprates is that two distinct scattering rates, τ −1 tr and τ −1 H , possibly govern the in-plane resistivity ρ ab and the Hall angle θ H , respectively. Zn impurities have been believed to induce 3,4 residual terms in both τ −1 tr and τ −1 H , which ultimately lead to charge localization 5 ; these residual scattering rates may well be related 6 to the local moments induced by the nonmagnetic Zn impurities, 7 though the role of the local moments in the charge transport in cuprates is not well understood yet. It would thus be meaningful to look for some peculiar features that is clearly due to the local moments in the transport properties of the Zn-doped BSLCO crystals. Perhaps the best-known effect of Zn-doping in cuprates is the rapid suppression of T c. The rate of T c suppression has been known to be around 10-15 K/at.% upon Zn substitution. It has been suggested 8,9 that this rate can be enhanced to ∼20 K/at.% near the hole concentration per Cu, p, of 1/8, which was discussed to be due to the "pinning" 10 of the charge stripes 11 by Zn impurities. Since it was recently revealed 12 that the metal-to-insulator (M-I) crossover in the low-temperature norm...