The Chaenomeles sinensis Extract has the Potential to Exhibit Antioxidant Activity or Attenuate Liver Damage

Abstract

Even though Chaenomeles sinensis is extensively used as a medicinal product to cure coughs, little is known about the biomedical efficacies of C. sinensis. In this study, we report the novel efficacy of C. sinensis extract (Cs-E01). Our 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide anion scavenging assays revealed that Cs-E01 exhibits strong antioxidant activity in vitro. In addition, Cs-E01 played a negative role in transforming growth factor (TGF-β1)-induced gene expression in LX-2 cells, suggesting that Cs-E01 is related to the cellular pathway suppressing liver damage.